Results 21 to 30 of about 8,568 (185)
Neurobiology of Disease, 2020 A number of publications have reported that cysteamine has significant therapeutic effects on several aspects of Parkinson's disease (PD)-related pathology but none of these studies have evaluated its impact on pathological forms of α-Synuclein (α-Syn ...
Alberto Siddu +7 more
doaj +1 more source
The specificity of cysteamine oxygenase
FEBS Letters, 1975 Oxidation of cysteamine to hypotaurine is catalyzed by cysteamine oxygenase (EC 1.13.11.19), a non-heme iron enzyme of large distribution [l-3] . A similar oxidation of cysteine to cysteine sulfinic acid has been reported to require a different oxygenase [4,.5]. Specificity of cysteamine oxygenase has been studied earlier in this laboratory by assaying
Cavallini, D. +5 more
openaire +2 more sources
Angewandte Chemie, EarlyView.We introduce a novel chemical derivatisation strategy for the UV‐activated detection of elusive metabolites. Incorporation of a tocopherol‐active chromophore allows for the detection of tagged analytes as photoionised radical cations, selectively induced by a 266 nm laser.
Sofia R. McGowan +5 more
wiley +2 more sources
Journal of Chemistry, 2013 A carbon-paste electrode modified with ferrocenecarboxaldehyde and NiO nanoparticle (NiO/NPs) was used for the sensitive and selective voltammetric determination of cysteamine in the presence of tryptophan.
Hassan Karimi-Maleh +4 more
doaj +1 more source
Hayati Journal of Biosciences, 2020 Low nuclear maturation and fertilization rate is one obstacle in the in vitro embryo production which decrease embryo yield. This problem is presumable related with high production of reactive oxygen species (ROS) during maturation process.
Feni Dwi Kartika Gulo +2 more
doaj +1 more source
Cysteamine ophthalmic hydrogel for the treatment of ocular cystinosis [PDF]
Farmacia Hospitalaria, 2017 Ocular cystinosis is a rare disease characterised by the deposit of cystine crystals on the corneal surface, which hinder patients’ eyesight. Oral cysteamine is given as cysteamine; however, it does not reach the cornea due to the lack of corneal ...
Anxo Fernández-Ferreiro +9 more
doaj +1 more source
Angewandte Chemie, EarlyView.Achieving selective (sp3)C–H hydroxylation can streamline the synthesis of complex organic molecules. Biocatalysis presents an opportunity to realize this transformation, however, identifying useful enzymes that enable synthetic strategies can be a challenge due to limitations in enzyme substrate scope.
Gonzalo J. Villegas Rodríguez +5 more
wiley +2 more sources
Limitations and Challenges in the Stability of Cysteamine Eye Drop Compounded Formulations
Pharmaceuticals, 2021 Accumulation of cystine crystals in the cornea of patients suffering from cystinosis is considered pathognomonic and can lead to severe ocular complications.
Cristina Martín-Sabroso +7 more
doaj +1 more source
A monoclinic polymorph of cysteamine hydrochloride [PDF]
Acta Crystallographica Section E Structure Reports Online, 2009 cloruro de 2-mercaptoetano-aminio), C(2)H(8)NS(+)·Cl(-), la sal de hidrocloruro de cisteamina, en contraste con el polimorfo triclínico previamente informado [Kim et al. (2002▶). Polyhedron, 21, 225-228], cristalizado en el sistema cristalino monoclínico.
Saeed Ahmad +2 more
openaire +4 more sources
Repression of Virulence in Staphylococcus aureus by 2‐Aminothiol‐Mediated Quorum Quenching
Angewandte Chemie, EarlyView.Simple analogues of cysteine that can eliminate the native autoinducing peptides (AIPs) of staphylococci extracellularly, before they activate their receptor, and turn off quorum sensing in different Staphylococcus aureus. The elimination of AIPs occurs through a mechanism similar to native chemical ligation (NCL). Further, this strategy showed promise
Bengt H. Gless +5 more
wiley +2 more sources