Results 41 to 50 of about 11,095 (222)

Limitations and Challenges in the Stability of Cysteamine Eye Drop Compounded Formulations

Pharmaceuticals, 2021
Accumulation of cystine crystals in the cornea of patients suffering from cystinosis is considered pathognomonic and can lead to severe ocular complications.
Cristina Martín-Sabroso, Mario Alonso-González, Ana Fernández-Carballido, Juan Aparicio-Blanco, Damián Córdoba-Díaz, Federico Navarro-García, Manuel Córdoba-Díaz, Ana I. Torres-Suárez   +7 more
doaj   +1 more source

Synthesis of diacylated γ-glutamyl-cysteamine prodrugs, and in vitro evaluation of their cytotoxicity and intracellular delivery of cysteamine [PDF]

, 2015
To overcome the major disadvantages of cysteamine, the only registered treatment for the rare genetic disease cystinosis, nine prodrugs of γ-glutamyl-cysteamine (4) were synthesized for evaluation.
Lisa Frost, Cannell, Stephanie, Pratap Suryadevara, Hambleton, Paul, Anderson, Rosaleen, Stephanie J. Cannell, Paul A. Hambleton, Frost, Lisa, Suryadevara, Pratap, Paul W. Groundwater, Groundwater, Paul, Rosaleen J. Anderson   +11 more
core   +1 more source

Myeloperoxidase-oxidase oxidation of cysteamine [PDF]

Biochemical Journal, 1988
Cysteamine oxidation was shown to be catalysed by nanomolar concentrations of myeloperoxidase in a peroxidase-oxidase reaction, i.e. an O2-consuming oxidation of a compound catalysed by peroxidase without H2O2 addition. When auto-oxidation of the thiol was prevented by the metal-ion chelator diethylenetriaminepenta-acetic acid, native, but not heat ...
B E, Svensson, S, Lindvall
openaire   +2 more sources

THE EFFECTIVITY OF CYSTEAMINE SUPPLEMENTATION ON IMPROVING THE IN VITRO FERTILIZATION RATE OF SHEEP OOCYTES

Jurnal Kedokteran Hewan, 2021
The purpose of this study was to evaluate the effectiveness of cysteamine supplementation on the maturation medium and/or in vitro fertilization medium with regards to improving the normal fertilization rate of sheep oocytes, which are characterized by ...
Dona Astari Nurkarimah, Ekayanti Mulyawati Kaiin, Ni Wayan Kurniani Karja, Mohamad Agus Setiadi   +3 more
doaj   +1 more source

Cysteamine with In Vitro Antiviral Activity and Immunomodulatory Effects Has the Potential to Be a Repurposing Drug Candidate for COVID-19 Therapy

Cells, 2021
The ongoing pandemic of coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), needs better treatment options both at antiviral and anti-inflammatory levels.
Tonino Alonzi, Alessandra Aiello, Linda Petrone, Saeid Najafi Fard, Manuela D’Eletto, Laura Falasca, Roberta Nardacci, Federica Rossin, Giovanni Delogu, Concetta Castilletti, Maria Rosaria Capobianchi, Giuseppe Ippolito, Mauro Piacentini, Delia Goletti   +13 more
doaj   +1 more source

Cysteamine attenuates the decreases in TrkB protein levels and the anxiety/depression-like behaviors in mice induced by corticosterone treatment. [PDF]

PLoS ONE, 2011
OBJECTIVE: Stress and glucocorticoid hormones, which are released into the circulation following stressful experiences, have been shown to contribute significantly to the manifestation of anxiety-like behaviors observed in many neuropsychiatric disorders.
Ammar Kutiyanawalla, Alvin V Terry, Anilkumar Pillai   +2 more
doaj   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Enteric-Coated Cysteamine Bitartrate in Cystinosis Patients [PDF]

Cystinosis is a severe inherited metabolic storage disease caused by the lysosomal accumulation of cystine. Lifelong therapy with the drug cysteamine bitartrate is necessary. Cysteamine cleaves intralysosomal cystine, and thereafter, it can exit from the
Rauwolf, K.K. (Kerstin), Harms, E. (Erik), Reunert, J. (Janine), Stein, C. (Christina) van, Ottolenghi, C. (Chris), Grebe, J. (Jürgen), Klank, S. (Sabrina), Grüneberg, M. (Marianne), Marquardt, T. (Thorsten)   +8 more
core   +1 more source

Spectroscopic Investigation of Cysteamine Dioxygenase

Biochemistry, 2020
Thiol dioxygenases are mononuclear non-heme FeII-dependent metalloenzymes that initiate the oxidative catabolism of thiol-containing substrates to their respective sulfinates. Cysteine dioxygenase (CDO), the best characterized mammalian thiol dioxygenase, contains a three-histidine (3-His) coordination environment rather than the 2-His-1-carboxylate ...
Rebeca L. Fernandez, Stephanie L. Dillon, Martha H. Stipanuk, Brian G. Fox, Thomas C. Brunold   +4 more
openaire   +3 more sources

Accelerating Biosensor Discovery: A Computationally‐Driven Pipeline for Microplastics Monitoring

Advanced Intelligent Discovery, EarlyView.
A computationally guided pipeline unites molecular simulation, synthetic biology, electrochemical engineering, and machine learning to accelerate biosensor discovery. A Bacillus anthracis carbohydrate‐binding module is used to develop a high‐performance micro‐ and nanoplastics sensor with greatly reduced error and variability.
Gabriel X. Pereira, Marcos de C. Leite, Pedro H. M. Zanineli, Juliana N. Y. Costa, Débora M. Cunha, Sophia P. Serra, Pedro H. Sophia, Flávio M. Shimizu, Yasmin W. Moura, Célio C. Oliveira, Gabriel R. Schleder, Gabriela F. Persinoti, Leandro Merces, Renato S. Lima   +13 more
wiley   +1 more source