Results 61 to 70 of about 11,095 (222)

Evaluation of NACA and diNACA in human cystinosis fibroblast cell cultures as potential treatments for cystinosis

Orphanet Journal of Rare Diseases, 2022
Background Cystinosis is a rare autosomal recessive lysosomal storage disease, associated with high morbidity and mortality. Mutations in the CTNS gene disable a membrane protein responsible for the transport of cystine out of the lysosome.
Emma Hector, Donald Cairns, G. Michael Wall   +2 more
doaj   +1 more source

From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities

Pharmaceuticals, 2023
We reviewed gastric ulcer healing by dopamine considering several distinctive duodenal key points. Selye and Szabo describe the cysteamine-induced duodenal ulcer in rats as a duodenal stress ulcer in patients.
Predrag Sikiric, Alenka Boban Blagaic, Ivan Krezic, Helena Zizek, Luka Kalogjera, Ivan Maria Smoday, Vlasta Vukovic, Katarina Oroz, Helen Marie Chiddenton, Sara Buric, Marko Antunovic, Slaven Gojkovic, Sanja Strbe, Milena Skocic, Suncana Sikiric, Marija Milavic, Lidija Beketic Oreskovic, Antonio Kokot, Antun Koprivanac, Ivan Dobric, Marko Sever, Mario Staresinic, Lovorka Batelja Vuletic, Anita Skrtic, Sven Seiwerth   +24 more
doaj   +1 more source

Copper deficiency in patients with cystinosis with cysteamine toxicity [PDF]

, 2013
Item does not contain fulltextOBJECTIVES: To assess whether copper deficiency plays a role in the recently described cysteamine toxicity in patients with cystinosis, and to examine whether polymorphisms in copper transporters, lysyl oxidase, and/or type ...
Lillen, Marc R, Heuvel, L.P.W.J. van den, Malfait, Fransiska, Lilien, M.R., Besouw, Martine T, De Paepe, Anne, Lilien, Marc R., Emma, Francesco, van den Heuvel, Lambertus P., Symoens, Sofie, Janssen, Mirian C., Janssen, M.C.H., Nobili, F., Emma, F., Skovby, Flemming, Besouw, Martine T P, Greco, Marcella, Desmet, K., Symoens, S., Janssen, Mirian C, Schneider, Jerry, Schneider, J., Besouw, M.T., Lilien, Marc R, Greco, M., Malfait, F., Cornelissen, Elisabeth A, Levtchenko, Elena N, Paepe, A. de, Skovby, F., van den Heuvel, Lambertus P, Levtchenko, E.N., Nobili, François, Cornelissen, Elisabeth A., Desmet, Koen, Besouw, Martine T. P., Cornelissen, E.A.M., Levtchenko, Elena N.   +37 more
core   +1 more source

Simple Synthesis Method and Characterizations of Aggregation-Free Cysteamine Capped PbS Quantum Dot

Applied Sciences, 2019
Quantum dots have diverse chemical properties with different ligands attached on the surface. The cysteamine has been used as a ligand for various quantum dots because it has high solubility in water, and it facilitates binding of quantum dot and gold ...
Daekyung Kang, Mareddi Bharath Kumar, Changhee Son, Hongsik Park, Jonghoo Park   +4 more
doaj   +1 more source

Cysteamine exerts in vitro antiviral activity against the SARS-CoV-2 Delta and Omicron variants

Cell Death Discovery, 2022
The novel SARS-CoV-2 variants of concern (VOC) represent a considerable global alarm because their mutations are known to affect transmissibility and cause immune escape.
Tonino Alonzi, Alessandra Aiello, Federica Repele, Laura Falasca, Massimo Francalancia, Anna Rosa Garbuglia, Giovanni Delogu, Emanuele Nicastri, Mauro Piacentini, Delia Goletti   +9 more
doaj   +1 more source

Halitosis in cystinosis patients after administration of immediate-release cysteamine bitartrate compared to delayed-release cysteamine bitartrate [PDF]

, 2012
Halitosis due to dimethylsulfide (DMS) generation is a major side effect of cysteamine in the treatment of cystinosis. Recently, an enteric coated formulation of cysteamine bitartrate (RP103) administered twice daily was demonstrated to be non-inferior ...
Levtchenko, Elena, Rioux, Patrice, Besouw, Martine, Cornelissen, Elisabeth, Tangerman, Albert   +4 more
core   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

Cysteamine Eye Drops in Hyaluronic Acid Packaged in Innovative Single-Dose Systems, Part II: Long-Term Stability and Clinical Ocular Biopermanence

Pharmaceutics, 2023
Background: Cystinosis is a rare genetic disorder characterized by the accumulation of cystine crystals in several tissues and organs causing, among others, severe eye symptoms.
Ana Castro-Balado, Andrea Cuartero-Martínez, Hugo Pena-Verdeal, Gonzalo Hermelo-Vidal, Anja Schmidt, Belén Montero, Manuela Hernández-Blanco, Irene Zarra-Ferro, Miguel González-Barcia, Cristina Mondelo-García, María Jesús Giráldez, Eva Yebra-Pimentel, Francisco J. Otero-Espinar, Anxo Fernández-Ferreiro   +13 more
doaj   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Cystamine and Cysteamine As Inhibitors of Transglutaminases In Vivo [PDF]

, 2018
Cystamine is commonly used as a transglutaminase inhibitor. This disulfide undergoes reduction in vivo to the aminothiol compound, cysteamine. Thus, the mechanism by which cystamine inhibits transglutaminase activity in vivo could be due to either ...
Jeitner, Thomas M, Cooper, Arthur J. L., Pinto, John T.   +2 more
core   +2 more sources