Results 11 to 20 of about 12,194 (220)
Challenges for cysteamine stabilization, quantification, and biological effects improvement
Journal of Pharmaceutical Analysis, 2020 The aminothiol cysteamine, derived from coenzyme A degradation in mammalian cells, presents several biological applications. However, the bitter taste and sickening odor, chemical instability, hygroscopicity, and poor pharmacokinetic profile of ...
Hélène Greige, Catherine Charcosset
exaly +4 more sources
International Journal of Pharmaceutics, 2020 Despite the high aqueous solubility of cysteamine, its unpleasant organoleptic properties, hygroscopicity, instability in solutions, and poor pharmacokinetic profile are the main drawbacks that limit its use for medical and cosmetic purposes. In this study, cysteamine-loaded liposomes were prepared using the ethanol injection method.
Hélène Greige, Catherine Charcosset
exaly +6 more sources
Enteric-Coated Cysteamine Bitartrate in Cystinosis Patients
Pharmaceutics, 2023 Cystinosis is a severe inherited metabolic storage disease caused by the lysosomal accumulation of cystine. Lifelong therapy with the drug cysteamine bitartrate is necessary. Cysteamine cleaves intralysosomal cystine, and thereafter, it can exit from the
Sabrina Klank +8 more
doaj +2 more sources
Orphanet Journal of Rare Diseases, 2021 Background Nephropathic cystinosis is a rare and severe metabolic disease leading to an accumulation of cystine in lysosomes which especially harms kidney function.
Christina van Stein +7 more
doaj +2 more sources
Synthesis Of Some Novel Silver-Cysteamine Complexes
Molecules, 2000 The aim of this research was to synthesize some new silver-cysteamine complexes of potential biological interest. Reactions were carried out between silver nitrate and cysteamine (2-aminoethanethiol hydrochloride) under different conditions of pH and ...
Davood Nematollahi +2 more
doaj +2 more sources
Cysteamine ophthalmic hydrogel for the treatment of ocular cystinosis [PDF]
Farmacia Hospitalaria, 2017 Ocular cystinosis is a rare disease characterised by the deposit of cystine crystals on the corneal surface, which hinder patients’ eyesight. Oral cysteamine is given as cysteamine; however, it does not reach the cornea due to the lack of corneal ...
Anxo Fernández-Ferreiro +9 more
doaj +5 more sources
EBioMedicine, 2015 Background: Cysteamine has recently been shown to have in vitro properties potentially therapeutically beneficial in cystic fibrosis (CF). In this study we investigated the antimicrobial and mucolytic activity of cysteamine against the complex biologic ...
Derry K Mercer +2 more
exaly +3 more sources
Inhibition of Low-Density Lipoprotein Oxidation by Cysteamine, Cystamine, Cysteine and Cystine at Lysosomal pH and pH 7.4 [PDF]
AntioxidantsLDL can be oxidised in the lysosomes of macrophages. Cysteamine, a thiol antioxidant that accumulates in lysosomes, inhibits the oxidation of LDL by iron at lysosomal pH (pH 4.5) and protects against atherosclerosis in mice.
Emily J. Parkes +8 more
doaj +2 more sources
A Review on Biomedical, Biomolecular, and Environmental Monitoring Applications of Cysteamine Functionalized Nanomaterials [PDF]
MicromachinesFunctionalizing agents enhance the photophysical properties of nanomaterials, thereby broadening their applications. Among these agents, cysteamine (SH-(CH2)2-NH2) is unique because of its free thiol (-SH) and amino (-NH2) groups.
Muthaiah Shellaiah
doaj +2 more sources
Cysteamine Inhibits Glycine Utilisation and Disrupts Virulence in Pseudomonas aeruginosa
Frontiers in Cellular and Infection Microbiology, 2021 Pseudomonas aeruginosa is a major opportunistic human pathogen which employs a myriad of virulence factors. In people with cystic fibrosis (CF) P. aeruginosa frequently colonises the lungs and becomes a chronic infection that evolves to become less ...
Douglas J. Fraser-Pitt +12 more
doaj +2 more sources