Results 51 to 60 of about 13,297 (156)

Nanoparticles in Periodontology and Implant Dentistry: From Mechanisms to Clinical Applications

open access: yesJournal of Periodontal Research, EarlyView.
Nanotechnology holds significant promise in improving dental care, yet there is a need for more reliable clinical studies to validate its effectiveness and safety. ABSTRACT Recent advances in nanotechnology are reshaping the landscape of periodontology and implant dentistry, particularly through the application of nanoparticles (NPs).
Chun Xu   +4 more
wiley   +1 more source

Plant NAOGAT (ArgJ) Structure Reveals Mechanism of Ornithine Biosynthesis, Preference for Acetylornithine and Susceptibility to Mangotoxin

open access: yesPlant, Cell &Environment, EarlyView.
ABSTRACT Arginine metabolism in plants is targeted by phytopathogens such as Pseudomonas syringae strains, which produce toxins that affect enzymes of plant arginine metabolism, causing devastating infections in crops. In this work, the structural and functional properties of plant N‐acetylornithine glutamate acetyltransferase (NAOGAT), the key ...
Maciej Nielipinski   +3 more
wiley   +1 more source

Maternal protein restriction programs the ageing kidney: Proteomic signatures of early‐life origin renal and metabolic dysfunction

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...
Marina Pereira Pires   +15 more
wiley   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

open access: yesEquine Veterinary Journal, Volume 58, Issue 6, Page 1552-1569, November 2026.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen   +8 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

open access: yesMedicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Cathepsin L in cancer: Context‐dependent functions, microenvironmental regulation and translational opportunities

open access: yesClinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Cathepsin L (CTSL) acts as a context‐dependent facilitator of tumour progression rather than a universal oncogenic driver. CTSL's pro‐tumorigenic functions are critically evaluated alongside its inherent biochemical constraints and family‐wide redundancy. CTSL‐related biology may provide translational opportunities in selected contexts.
Yujun Wu   +7 more
wiley   +1 more source

Localization and function ofRhipicephalus (Boophilus) microplusvitellin-degrading cysteine endopeptidase

open access: yesParasitology, 2010
SUMMARYThe tickRhipicephalus (Boophilus) microplusis an important parasite of cattle in many areas of the tropics. Characterization of molecules involved in mechanisms such as vitellogenesis and embryo development may contribute to a better understanding of this parasite's physiology.
Adriana, Seixas   +6 more
openaire   +2 more sources

Coat Color‐Associated Transcriptomic Differences of Black and White Hortobágyi Racka Sheep Using the RNA‐Seq Technique

open access: yesEcology and Evolution, Volume 16, Issue 10, October 2026.
We compared skin transcriptomes of black‐ and white‐coated Hortobágyi Racka sheep using RNA‐seq to identify coat color‐associated molecular differences. Black‐coated sheep showed coordinated upregulation of melanogenesis and melanosome‐related genes together with pathways linked to redox balance, mitochondrial metabolism, and thermogenesis.
Putri Kusuma Astuti   +3 more
wiley   +1 more source

Proteolytic Activity of Zingiber officinale Extract: Interaction With Myofibrillar Proteins of Different Origins and Functional Effects in Meat Systems

open access: yesFood Science &Nutrition, Volume 14, Issue 10, October 2026.
Ginger‐derived proteases were evaluated for their proteolytic activity toward isolated chicken and pork myofibrils and their effects during meat marination. The ginger extract showed a selective and moderate proteolytic activity, resulting in controlled protein degradation and improved meat quality, including tenderness, juiciness, flavor, and overall ...
Alessandro Crinò   +3 more
wiley   +1 more source

Advanced Glycation End Products: From Pathogenesis to Treatment

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Therapeutic landscape of AGE‐targeted intervention. Schematic representation of intervention strategies targeting distinct stages of AGE biology. Upstream prevention aims to reduce exposure and formation through low‐AGE cooking, smoking cessation, glycemic control, and metabolic optimization.
Tak‐Ho Lo   +7 more
wiley   +1 more source

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