Results 41 to 50 of about 219,552 (223)
Kinetic Characterization of Cerium and Gallium Ions as Inhibitors of Cysteine Cathepsins L, K, and S
International Journal of Molecular Sciences, 2022 Heavy metal ions can disrupt biological functions via multiple molecular mechanisms, including inhibition of enzymes. We investigate the interactions of human papain-like cysteine endopeptidases cathepsins L, K, and S with gallium and cerium ions, which ...
Marko Novinec +5 more
semanticscholar +1 more source
Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo [PDF]
, 2019 Detoxification of gluten immunogenic epitopes is a promising strategy for the treatment of celiac disease. Our previous studies have shown that these epitopes can be degraded in vitro by subtilisin enzymes derived from Rothia mucilaginosa, a natural ...
Darwish, Ghassan +4 more
core +1 more source
Purification and Characterization of a Cysteine Endopeptidase in Cotyledons of Germinated Mung Bean Seeds [PDF]
Plant Physiology, 1990 A cysteine endopeptidase (EC 3.4.22.-) present in cotyledons of mung bean (Vigna radiata) seedlings was purified to homogeneity, as judged by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). This proteinase has an apparent molecular mass of 33 kilodaltons as estimated by SDS-PAGE and belongs to the class of cysteine proteinases as ...
Y, Yamaoka, M, Takeuchi, Y, Morohashi
openaire +2 more sources
Substrate specificity and the effect of calcium on Trypanosomabrucei metacaspase 2 [PDF]
, 2013 Metacaspases are cysteine peptidases found only in yeast, plants and lower eukaryotes, including the protozoa. To investigate the extended substrate specificity and effects of Ca<sup>2+</sup> on the activation of these enzymes, detailed ...
Juliano, L. +7 more
core +1 more source
Journal of the European Academy of Dermatology and Venereology, 2022 Chronic pruritus is a highly prevalent and burdensome symptom. Antihistamines, which are still recommended first-line antipruritic treatment options are not effective in most pruritic conditions.
T. Hawro
semanticscholar +1 more source
Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG [PDF]
Proceedings of the National Academy of Sciences, 2004 Pathogenic bacteria have developed complex and diverse virulence mechanisms that weaken or disable the host immune defense system. IdeS (IgG-degrading e nzyme of Streptococcus pyogenes ) is a secreted cysteine endopeptidase from the human pathogen S.
Wenig, K. +5 more
openaire +3 more sources
Veterinary Research, 2019 Yersinia ruckeri is the causative agent of enteric redmouth disease in salmonids. In fish, the intestine represents an important site of nutrient uptake, host–pathogen interactions, and defense.
Gokhlesh Kumar +3 more
doaj +1 more source
Developments in plant breeding for improved nutritional quality of soya beans II. Anti-nutritional factors [PDF]
, 2000 Nutritional value of most plant materials is limited by the presence of numerous naturally occurring compounds which interfere with nutrient digestion and absorption.
Clarke, E, Wiseman, J
core +1 more source
Proteomes, 2018 The recent identification of catalytically active peptidylglycine α-amidating monooxygenase (PAM) in Chlamydomonas reinhardtii, a unicellular green alga, suggested the presence of a PAM-like gene and peptidergic signaling in the last eukaryotic ...
Raj Luxmi +6 more
doaj +1 more source
FEBS Letters, 1998 We show by site‐directed mutagenesis that the catalytic residues of mammalian legumain, a recently discovered lysosomal asparaginycysteine endopeptidase, form a catalytic dyad in the motif His‐Gly‐spacer‐Ala‐Cys. We note that the same motif is present in
Jinq-May Chen +3 more
semanticscholar +1 more source