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Exploration of Microbially Derived Natural Compounds against Monkeypox Virus as Viral Core Cysteine Proteinase Inhibitors [PDF]

Viruses, 2023
Monkeypox virus (MPXV) is a member of the Orthopoxvirus genus and the Poxviridae family, which instigated a rising epidemic called monkeypox disease.
Amit Dubey, Maha M. Alawi, Thamir A. Alandijany, Isra M. Alsaady, Sarah A. Altwaim, Amaresh Kumar Sahoo, Vivek Dhar Dwivedi, Esam Ibraheem Azhar   +7 more
doaj   +2 more sources

Cysteine peptidases and their inhibitors in breast and genital cancer.

Folia Histochemica et Cytobiologica, 2010
Cysteine proteinases and their inhibitors probably play the main role in carcinogenesis and metastasis. The metastasis process need external proteolytic activities that pass several barriers which are membranous structures of the connective tissue which ...
Magdalena Milan, Zygmunt Grzebieniak, Dorota Zyoeko, Elżbieta Teterycz, Godwin Bwire Ekonjo, Anil Kumar Agrawal, Grzegorz Marek, Maciej Siewiński   +7 more
doaj   +4 more sources

Computational investigation of potential natural compounds as inhibitors of monkeypox virus cysteine proteinase [PDF]

Frontiers in Bioinformatics
IntroductionMonkeypox is a serious viral illness that is rarely seen but is spread from person to person and from animals to humans. Cysteine proteinase, an essential enzyme involved in the replication of the monkeypox virus (MPXV), is one of many ...
Riya Nalwa, Anis Ahmad Chaudhary, Mandeep Chouhan, Prashant Kumar Tiwari, Saurabh Gupta, Hassan Ahmed Rudayni, Vivek Dhar Dwivedi, Vivek Dhar Dwivedi, Sanjay Kumar, Sanjay Kumar, Sanjay Kumar   +10 more
doaj   +2 more sources

The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]

International Journal of Medical Toxicology and Forensic Medicine, 2020
Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara, Ehsan Jahangirian, Hossein Tarrahimofrad   +2 more
doaj   +1 more source

Repurposing Anti-Dengue Compounds against Monkeypox Virus Targeting Core Cysteine Protease

Biomedicines, 2023
The monkeypox virus (MPXV) is an enveloped, double-stranded DNA virus belonging to the genus Orthopox viruses. In recent years, the virus has spread to countries where it was previously unknown, turning it into a worldwide emergency for public health ...
Mohd Imran, Abida, Nawaf M. Alotaibi, Hamdy Khamees Thabet, Jamal Alhameedi Alruwaili, Lina Eltaib, Ahmed Alshehri, Ahad Amer Alsaiari, Mehnaz Kamal, Abdulmajeed Mohammed Abdullah Alshammari   +9 more
doaj   +1 more source

Melia azedarach L. extract induced the production of phytocystatin in passion fruit leaves

Hoehnea, 2021
Phytocystatins belong to the family of cysteine proteinases inhibitors. These proteinase inhibitors have crucial functions in plant defense against insects and pathogens attack. In the present study Melia azedarach L. extract acts as an elicitor of plant
Alyne Bispo Rodrigues, César Luis Siqueira Junior   +1 more
doaj   +1 more source

Vacuolar Processing Enzymes Modulating Susceptibility Response to Fusarium oxysporum f. sp. cubense Tropical Race 4 Infections in Banana

Frontiers in Plant Science, 2022
Fusarium oxysporum f. sp. cubense tropical race 4 (FocTR4) is a destructive necrotrophic fungal pathogen afflicting global banana production. Infection process involves the activation of programmed cell death (PCD).
Wan Muhamad Asrul Nizam Wan Abdullah, Noor Baity Saidi, Mohd Termizi Yusof, Chien-Yeong Wee, Hwei-San Loh, Hwei-San Loh, Janna Ong-Abdullah, Kok-Song Lai   +7 more
doaj   +1 more source

Coffee cysteine proteinases and related inhibitors with high expression during grain maturation and germination

BMC Plant Biology, 2012
Background Cysteine proteinases perform multiple functions in seeds, including participation in remodelling polypeptides and recycling amino acids during maturation and germination.
Lepelley Maud, Amor Mohamed, Martineau Nelly, Cheminade Gerald, Caillet Victoria, McCarthy James   +5 more
doaj   +1 more source

Inhibition of Plant-Pathogenic Fungi by the Barley Cystatin Hv-CPI (Gene Icy) Is Not Associated with Its Cysteine-Proteinase Inhibitory Properties

Molecular Plant-Microbe Interactions, 2003
The recombinant barley cystatin Hv-CPI inhibited the growth of three phytopathogenic fungi (Botrytis cinerea, Colletotrichum graminicola, and Plectosphaerella cucumerina) and the saprotrophic fungus Trichoderma viride.
M. Martínez, E. López-Solanilla, P. Rodríguez-Palenzuela, P. Carbonero, I. Díaz   +4 more
doaj   +1 more source

Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity

Virology Journal, 2005
Through the use of transient expression assays and directed genetics, the vaccinia virus (VV) I7L gene product has been implicated as the major maturational proteinase required for viral core protein cleavage to occur during virion assembly.
Hruby Dennis E, Byrd Chelsea M
doaj   +1 more source