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Computational investigation of potential natural compounds as inhibitors of monkeypox virus cysteine proteinase [PDF]
Frontiers in BioinformaticsIntroductionMonkeypox is a serious viral illness that is rarely seen but is spread from person to person and from animals to humans. Cysteine proteinase, an essential enzyme involved in the replication of the monkeypox virus (MPXV), is one of many ...
Riya Nalwa +10 more
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Exploration of Microbially Derived Natural Compounds against Monkeypox Virus as Viral Core Cysteine Proteinase Inhibitors [PDF]
Viruses, 2023 Monkeypox virus (MPXV) is a member of the Orthopoxvirus genus and the Poxviridae family, which instigated a rising epidemic called monkeypox disease.
Amit Dubey +7 more
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Cysteine proteinase inhibitors in murine cysticercosis. [PDF]
Antimicrob Agents Chemother, 2006 ABSTRACT We explored the prophylactic efficacies of two novel protease inhibitors in murine cysticercosis. Our results demonstrated a 95% and 80% reduction in parasite burden for mice injected with Z-LLL-FMK and Z-LLY-FMK, respectively. Further studies are merited on the role of cysteine proteinase inhibitors in treatment of cysticercosis.
Baig S +7 more
europepmc +4 more sources
The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara +2 more
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Cystatins — Inhibitors of Cysteine Proteinases [PDF]
Critical Reviews in Oral Biology & Medicine, 1992 The cystatin superfamily of proteins, derived from a common ancestor, is comprised of a diverse group of potent cysteine proteinase inhibitors and antibacterial/viral agents grouped into several families. This review concentrates on family 2 cystatins, namely, the human salivary cystatins and cystatin C.
L A, Bobek, M J, Levine
openaire +2 more sources
Melia azedarach L. extract induced the production of phytocystatin in passion fruit leaves
Hoehnea, 2021 Phytocystatins belong to the family of cysteine proteinases inhibitors. These proteinase inhibitors have crucial functions in plant defense against insects and pathogens attack. In the present study Melia azedarach L. extract acts as an elicitor of plant
Alyne Bispo Rodrigues +1 more
doaj +1 more source
Repurposing Anti-Dengue Compounds against Monkeypox Virus Targeting Core Cysteine Protease
Biomedicines, 2023 The monkeypox virus (MPXV) is an enveloped, double-stranded DNA virus belonging to the genus Orthopox viruses. In recent years, the virus has spread to countries where it was previously unknown, turning it into a worldwide emergency for public health ...
Mohd Imran +9 more
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Frontiers in Plant Science, 2022 Fusarium oxysporum f. sp. cubense tropical race 4 (FocTR4) is a destructive necrotrophic fungal pathogen afflicting global banana production. Infection process involves the activation of programmed cell death (PCD).
Wan Muhamad Asrul Nizam Wan Abdullah +7 more
doaj +1 more source
Cysteine peptidases and their inhibitors in breast and genital cancer.
Folia Histochemica et Cytobiologica, 2010 Cysteine proteinases and their inhibitors probably play the main role in carcinogenesis and metastasis. The metastasis process need external proteolytic activities that pass several barriers which are membranous structures of the connective tissue which ...
Magdalena Milan +7 more
doaj +1 more source
BMC Plant Biology, 2012 Background Cysteine proteinases perform multiple functions in seeds, including participation in remodelling polypeptides and recycling amino acids during maturation and germination.
Lepelley Maud +5 more
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