Results 11 to 20 of about 28,630 (299)

Osteoclastogenesis is decreased by cysteine proteinase inhibitors

Bone, 2004
The effects of cystatin C and other cysteine proteinase inhibitors on osteoclast formation and differentiation have been investigated. Cystatin C decreased osteoclast formation stimulated by parathyroid hormone (PTH), 1,25(OH)(2)-vitamin D3 or ...
Kasprzykowski, F, Lerner, Ulf,, Lie, A, Grubb, Anders, Grubb, Anders,, Lie, Anita, Abrahamson, M, Kasprzykowska, Regina, Kasprzykowski, Franciszek, Lerner, Ulf H,, Grubb, A, Ransjo, M, Ransjö, Maria,, Abrahamson, Magnus, Lie, Anita,, Kasprzykowska, R, Brage, Monica, Ransjö, Maria, Lerner, UH, Lund University., Brage, M, Abrahamson, Magnus,   +21 more
core   +3 more sources

Cysteine proteinase inhibitors in murine cysticercosis. [PDF]

Antimicrob Agents Chemother, 2006
ABSTRACT We explored the prophylactic efficacies of two novel protease inhibitors in murine cysticercosis. Our results demonstrated a 95% and 80% reduction in parasite burden for mice injected with Z-LLL-FMK and Z-LLY-FMK, respectively. Further studies are merited on the role of cysteine proteinase inhibitors in treatment of cysticercosis.
Baig S, Damian RT, Morales-Montor J, Thazhath R, Ghaleb A, Welch M, Talhouk J, White AC.   +7 more
europepmc   +4 more sources

Cystatins — Inhibitors of Cysteine Proteinases [PDF]

Critical Reviews in Oral Biology & Medicine, 1992
The cystatin superfamily of proteins, derived from a common ancestor, is comprised of a diverse group of potent cysteine proteinase inhibitors and antibacterial/viral agents grouped into several families. This review concentrates on family 2 cystatins, namely, the human salivary cystatins and cystatin C.
L A, Bobek, M J, Levine
openaire   +2 more sources

Primary structure of potato Kunitz-type serine proteinase inhibitor [PDF]

, 2000
The serine proteinase inhibitor (PSPI-51) isolated from potato tubers (Solanum tuberosum L,) comprises two protein species with pi 5.2 and 6.3, denoted as PSPI-21-5.2 and PSPI-21-6.3, respectively.
Mentele, Reinhard, Valueva, Tatyana A., Revina, Tatyana A., Mosolov, Vladimir V.   +3 more
core   +1 more source

Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB [PDF]

, 2013
Cysteine proteases of the papain superfamily are present in nearly all eukaryotes. They play pivotal roles in the biology of parasites and inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as sleeping
Mottram, Jeremy C, Mottram Jeremy C., Richard J Marhöfer, Schröder Jörg, Selzer, P.M., Schroder, J., Noack, Sandra, Noack Sandra, Schröder, Jörg, Noack, S., Mottram, J.C., Sandra Noack, Coombs, G.H., Coombs, Graham H, Marhöfer, Richard J, Coombs Graham H., Paul M Selzer, Jeremy C Mottram, Marhöfer Richard J., Marhofer, R.J., Jörg Schröder, Selzer Paul M., Selzer, Paul M, Selzer, Paul M., Graham H Coombs   +24 more
core   +1 more source

The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases [PDF]

Biochemical Journal, 1986
A synthesis of peptidylfluoromethanes is described that utilizes the conversion of phthaloyl amino acids into their fluoromethane derivatives. These can be deblocked and elongated. The inactivation of chymotrypsin by Cbz-Phe-CH2F (benzyloxycarbonylphenylalanylfluoromethane) was found to be considerably slower than that of the analogous chloromethane ...
P, Rauber, H, Angliker, B, Walker, E, Shaw   +3 more
openaire   +2 more sources

Digestive proteolytic activity in the gut and salivary glands of the predatory bug Podisus maculiventris (Heteroptera: Pentatomidae); effect of proteinase inhibitors

European Journal of Entomology, 2005
Proteinase activity in the midgut of the pentatomid stinkbug Podisus maculiventris was investigated. The optimal pH for adult and nymph proteolysis was pH 6.0 and pH 6.5, respectively.
Howard A. BELL, Rachel E. DOWN, John P. EDWARDS, John A. GATEHOUSE, Angharad M.R. GATEHOUSE   +4 more
doaj   +1 more source

The tick-derived anticoagulant madanin is processed by thrombin and factor Xa. [PDF]

PLoS ONE, 2013
The cysteine-less peptidic anticoagulants madanin-1 and madanin-2 from the bush tick Haemaphysalis longicornis are the founding members of the MEROPS inhibitor family I53.
Ana C Figueiredo, Daniele de Sanctis, Pedro José Barbosa Pereira   +2 more
doaj   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source

Expression of two barley proteinase inhibitors in tomato promotes endogenous defensive response and enhances resistance to Tuta absoluta

BMC Plant Biology, 2018
Background Plants and insects have coexisted for million years and evolved a set of interactions which affect both organisms at different levels. Plants have developed various morphological and biochemical adaptations to cope with herbivores attacks ...
Rim Hamza, Meritxell Pérez-Hedo, Alberto Urbaneja, José L. Rambla, Antonio Granell, Kamel Gaddour, José P. Beltrán, Luis A. Cañas   +7 more
doaj   +1 more source