Results 21 to 30 of about 753,077 (248)

Extracellular Matrix of Echinoderms

open access: yesMarine Drugs, 2023
This review considers available data on the composition of the extracellular matrix (ECM) in echinoderms. The connective tissue in these animals has a rather complex organization.
Igor Yu. Dolmatov   +1 more
doaj   +1 more source

An overview of Phoneutria nigriventer spider venom using combined transcriptomic and proteomic approaches. [PDF]

open access: yesPLoS ONE, 2018
Phoneutria nigriventer is one of the largest existing true spiders and one of the few considered medically relevant. Its venom contains several neurotoxic peptides that act on different ion channels and chemical receptors of vertebrates and invertebrates.
Marcelo R V Diniz   +8 more
doaj   +1 more source

A multi-targeted computational drug discovery approach for repurposing tetracyclines against monkeypox virus

open access: yesScientific Reports, 2023
Monkeypox viral infection is an emerging threat and a major concern for the human population. The lack of drug molecules to treat this disease may worsen the problem.
Thamir A. Alandijany   +8 more
doaj   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

open access: yes, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito   +6 more
core   +1 more source

"Purification and evaluation of somatic, excretory-secretory and Cysteine proteinase antigens of Fasciola Hepatica using IgG-ELISA in diagnosing Fascioliasis " [PDF]

open access: yesActa Medica Iranica, 2001
Fasciolosis, or liver fluke disease, caused by parasites of the genus Fasciola is emerging as an important disease in man and animals, in the world and Iran, particularly in nortern parts. The economical losses in domestic animals are considerable.
"Rokni MB   +3 more
doaj   +2 more sources

Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain [PDF]

open access: yes, 2001
Within the cystatin superfamily, only kininogen domain 2 (KD2) is able to inhibit μ- and m-calpain. In an attempt to elucidate the structural requirements of cystatins for calpain inhibition, we constructed recombinant hybrids of human stefin B (an ...
Gross, Stefan   +9 more
core   +1 more source

Biochemical properties of digestive carbohydrases and proteases of cereal leaf beetle, Lema melanopa (Coleoptera: Chrysomelidae) [PDF]

open access: yesنامه انجمن حشره‌شناسی ایران, 2020
In the recent decade, Lema melanopa L. has become one of the most important pests of wheat fields in Golstan province. Both adults and larvae of this pest feed on the leaves of most cereals and of course wheat and cause severe damage.
Mahboobeh Sharifi   +2 more
doaj   +1 more source

Family C1 cysteine proteases: Biological diversity or redundancy? [PDF]

open access: yes, 2003
Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes.
Nägler, D. K.   +3 more
core   +1 more source

Perspectives of digestive pest control with proteinase inhibitors that mainly affect the trypsin-like activity of Anticarsia gemmatalis Hübner (Lepidoptera: Noctuidae)

open access: yesBrazilian Journal of Medical and Biological Research, 2005
The present study describes the main characteristics of the proteolytic activities of the velvetbean caterpillar, Anticarsia gemmatalis Hübner, and their sensitivity to proteinase inhibitors and activators.
M.E. Pereira   +5 more
doaj   +1 more source

The effects of a plant proteinase inhibitor from Enterolobium contortisiliquum on human tumor cell lines [PDF]

open access: yes, 2011
Supplementary to the efficient inhibition of trypsin, chymotrypsin, plasma kallikrein, and plasmin already described by the EcTI inhibitor from Enterolobium contortisiliquum, it also blocks human neutrophil elastase (K(iapp)=4.3 nM) and prevents phorbol ...
Sampaio, Misako U. [UNIFESP]   +21 more
core   +1 more source

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