Results 1 to 10 of about 57,159 (156)
A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis [PDF]
Arthritis Research & Therapy, 2023 Background Systemic sclerosis (SSc) is a connective tissue disease that is characterized by fibrosis in the skin and internal organs, such as the lungs.
Hiroshi Kasamatsu +7 more
doaj +2 more sources
Developing novel anthelmintics: the stability of cysteine proteinase activity in a supernatant extract of papaya latex [PDF]
Heliyon, 2021 Plant derived cysteine proteinases (CPs) have long been known to possess anthelmintic properties but have attracted renewed attention recently because of the acute need to discover novel methods for controlling helminth infections as a result of ...
F.A.F. Mansur +5 more
doaj +2 more sources
Cysteine Proteinase C1A Paralog Profiles Correspond with Phylogenetic Lineages of Pathogenic Piroplasmids [PDF]
Veterinary Sciences, 2018 Piroplasmid parasites comprising of Babesia, Theileria, and Cytauxzoon are transmitted by ticks to farm and pet animals and have a significant impact on livestock industries and animal health in tropical and subtropical regions worldwide.
Mariano E. Ascencio +5 more
doaj +2 more sources
Cysteine proteinases and cystatins [PDF]
Brazilian Archives of Biology and Technology, 2003 This review describeds the definition, localization, functions and examples of cysteine proteinases and their protein inhibitors in vertebrate, non-vertebrate animals and plants. These inhibitors are related with defense mechanisms of plant against pests.
Adeliana S. Oliveira +2 more
doaj +4 more sources
Computational investigation of potential natural compounds as inhibitors of monkeypox virus cysteine proteinase [PDF]
Frontiers in BioinformaticsIntroductionMonkeypox is a serious viral illness that is rarely seen but is spread from person to person and from animals to humans. Cysteine proteinase, an essential enzyme involved in the replication of the monkeypox virus (MPXV), is one of many ...
Riya Nalwa +10 more
doaj +2 more sources
Putrescine-dependent re-localization of TvCP39, a cysteine proteinase involved in Trichomonas vaginalis cytotoxicity. [PDF]
PLoS ONE, 2014 Polyamines are involved in the regulation of some Trichomonas vaginalis virulence factors such as the transcript, proteolytic activity, and cytotoxicity of TvCP65, a cysteine proteinase (CP) involved in the trichomonal cytotoxicity.
Bertha Isabel Carvajal-Gamez +6 more
doaj +2 more sources
Cysteine proteinase inhibitors in murine cysticercosis. [PDF]
Antimicrob Agents Chemother, 2006 ABSTRACT We explored the prophylactic efficacies of two novel protease inhibitors in murine cysticercosis. Our results demonstrated a 95% and 80% reduction in parasite burden for mice injected with Z-LLL-FMK and Z-LLY-FMK, respectively. Further studies are merited on the role of cysteine proteinase inhibitors in treatment of cysticercosis.
Baig S +7 more
europepmc +4 more sources
The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara +2 more
doaj +1 more source
Viral cysteine proteinases [PDF]
Perspectives in Drug Discovery and Design, 1996 Dozens of novel cysteine proteinases have been identified in positive single-stranded RNA viruses and, for the first time, in large double-stranded DNA viruses. The majority of these proteins are distantly related to papain or chymotrypsin and may be direct descendants of primordial proteolytic enzymes.
Gorbalenya, Alexander E. +1 more
openaire +2 more sources
Neurobiology of Disease, 2021 Parkinson's disease (PD) is one of the most common neurodegenerative diseases, which is characterized by the loss of dopaminergic neurons in the nigrostriatal pathway.
Li Zou +13 more
doaj +1 more source