A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis [PDF]
Arthritis Research & Therapy, 2023 Background Systemic sclerosis (SSc) is a connective tissue disease that is characterized by fibrosis in the skin and internal organs, such as the lungs.
Hiroshi Kasamatsu +7 more
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Developing novel anthelmintics: the stability of cysteine proteinase activity in a supernatant extract of papaya latex [PDF]
Heliyon, 2021 Plant derived cysteine proteinases (CPs) have long been known to possess anthelmintic properties but have attracted renewed attention recently because of the acute need to discover novel methods for controlling helminth infections as a result of ...
F.A.F. Mansur +5 more
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Cysteine Proteinase C1A Paralog Profiles Correspond with Phylogenetic Lineages of Pathogenic Piroplasmids [PDF]
Veterinary Sciences, 2018 Piroplasmid parasites comprising of Babesia, Theileria, and Cytauxzoon are transmitted by ticks to farm and pet animals and have a significant impact on livestock industries and animal health in tropical and subtropical regions worldwide.
Mariano E. Ascencio +5 more
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Computational investigation of potential natural compounds as inhibitors of monkeypox virus cysteine proteinase [PDF]
Frontiers in BioinformaticsIntroductionMonkeypox is a serious viral illness that is rarely seen but is spread from person to person and from animals to humans. Cysteine proteinase, an essential enzyme involved in the replication of the monkeypox virus (MPXV), is one of many ...
Riya Nalwa +10 more
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Cysteine proteinases and cystatins [PDF]
Brazilian Archives of Biology and Technology, 2003 This review describeds the definition, localization, functions and examples of cysteine proteinases and their protein inhibitors in vertebrate, non-vertebrate animals and plants. These inhibitors are related with defense mechanisms of plant against pests.
Adeliana S. Oliveira +2 more
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Putrescine-dependent re-localization of TvCP39, a cysteine proteinase involved in Trichomonas vaginalis cytotoxicity. [PDF]
PLoS ONE, 2014 Polyamines are involved in the regulation of some Trichomonas vaginalis virulence factors such as the transcript, proteolytic activity, and cytotoxicity of TvCP65, a cysteine proteinase (CP) involved in the trichomonal cytotoxicity.
Bertha Isabel Carvajal-Gamez +6 more
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Exploring the protease inhibitory potential of 2-bromo-2-nitro-1,3- propanediol (Bronopol): Initial findings [PDF]
Biochemistry and Biophysics ReportsThe compound 2-bromo-2-nitropropane-1,3-diol also known as Bronopol (BP) is a widely used antimicrobial preservative which highly soluble in water. Although its antimicrobial mechanism has been well described, its potential to modulate protease activity ...
Chao Jiang +2 more
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The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara +2 more
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Viral cysteine proteinases [PDF]
Perspectives in Drug Discovery and Design, 1996 Dozens of novel cysteine proteinases have been identified in positive single-stranded RNA viruses and, for the first time, in large double-stranded DNA viruses. The majority of these proteins are distantly related to papain or chymotrypsin and may be direct descendants of primordial proteolytic enzymes.
Gorbalenya, Alexander E. +1 more
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Cysteine Proteinases and the Pathogenesis of Amebiasis [PDF]
Clinical Microbiology Reviews, 2000 SUMMARYAmebiasis is a major cause of morbidity and mortality throughout the tropical world. Entamoeba histolytica is now recognized as a separate species from the morphologically identical E. dispar, which cannot invade. Cysteine proteinases are a key virulence factor of E.
X, Que, S L, Reed
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