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Biomedicines, 2022 Cathepsins are lysosomal proteases that are essential to maintain cellular physiological homeostasis and are involved in multiple processes, such as immune and energy regulation.
Hester van Mourik +2 more
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Shaping the Immune Response: Cathepsins in Virus-Dendritic Cell Interactions [PDF]
CellsDendritic cells (DCs) are among the first immune cells to detect viral invasion and play a central role in initiating and shaping antiviral immune responses.
Adrianna Niedzielska +5 more
doaj +2 more sources
Cathepsins Trigger Cell Death and Regulate Radioresistance in Glioblastoma
Cells, 2022 Treatment of glioblastoma (GBM) remains very challenging, and it is particularly important to find sensitive and specific molecular targets. In this work, we reveal the relationship between the expression of cathepsins and radioresistance in GBM.
Minghua
exaly +3 more sources
The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease
Frontiers in Cell and Developmental Biology, 2017 Kidney disease is worldwide the 12th leading cause of death affecting 8–16% of the entire population. Kidney disease encompasses acute (short-lasting episode) and chronic (developing over years) pathologies both leading to renal failure.
Valeria De Pasquale +2 more
exaly +3 more sources
Frontiers in Immunology, 2022 Cathepsins were first described, as endolysosomal proteolytic enzymes in reference to the organelles where they degrade the bulk of endogenous and exogenous substrates in a slightly acidic environment.
Elsa Anes, David Pires, Manoj
exaly +3 more sources
Targeting Cathepsins in Neurodegeneration: Biochemical Advances [PDF]
BiomedicinesBackground/Objectives: Cathepsins, lysosomal proteases crucial for neuronal proteostasis, mediate the clearance of misfolded and aggregated proteins. Their dysregulation is implicated in neurodegenerative and neuropsychiatric disorders such as Alzheimer ...
Francesca Di Matteo +14 more
doaj +2 more sources
CD74-Targeted Cathepsin-Inhibitor Antibody–Drug Conjugate Triggers Apoptosis in DLBCL [PDF]
CellsTranscriptomic analyses of public datasets (TCGA and GTEx) revealed that both CD74 and Cathepsin L (CTSL) are significantly overexpressed in diffuse large B-cell lymphoma (DLBCL) compared to normal tissues, and that their expression levels are highly ...
Ihab Abd-Elrahman +7 more
doaj +2 more sources
Expression of Cathepsins B, D, and G in Extracranial Arterio-Venous Malformation
Frontiers in Surgery, 2021 Objectives: We have previously identified a population of cells that expressed stemness-associated markers in extracranial arterio-venous malformation (AVM) and demonstrated expression of cathepsins B, D, and G on embryonic stem cell (ESC)-like ...
Lauren Hansen +8 more
doaj +1 more source
Frontiers in Immunology, 2021 Cysteine cathepsins are primarily involved in the degradation and recycling of proteins in endo-lysosomal compartments but are also gaining recognition as pivotal proteolytic contributors to various immune functions.
Milica Perišić Nanut +4 more
doaj +1 more source
Cathepsins B, D, and G Are Expressed in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma
Frontiers in Oncology, 2021 AimWe have previously demonstrated the presence of two cancer stem cell (CSC) subpopulations within metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC) expressing components of the renin-angiotensin system (RAS), which promotes ...
Felix Humphries +8 more
doaj +1 more source