Results 31 to 40 of about 20,637 (212)
Advanced Science, EarlyView.We report a chromogenic release‐based assay system with protease‐cleavage peptide‐modified calcium carbonate microspheres for colorimetric detection of Porphyromonas (P.) gingivalis activity. In response to Arg‐specific gingipain secreted by P. gingivalis, the supernatant becomes colored, enabling colorimetric analysis and providing the monitoring of ...
Yuki Hiruta +9 more
wiley +1 more source
Angewandte Chemie, EarlyView.Gal‐SeNBD‐oleamide is an activatable photosensitizer (PS) with efficient uptake and selective, β‐galactosidase‐triggered activation in cancer cells, enabling efficient photodynamic ablation of glioma cells directly in brain tissue slices from mouse preclinical models and human glioblastoma patients.
Utsa Karmakar +18 more
wiley +2 more sources
Role of cathepsin A and cathepsin C in the regulation of glycosidase activity
Folia Histochemica et Cytobiologica, 2012 Increased tissue activity of cathepsin A and cathepsin C can be observed in many pathological conditions. It is associated with an enhanced degradation of glycosaminoglycans, proteoglycans, and glycoproteins, and results in their decreased tissue content. Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their
Anna Justyna Milewska +4 more
openaire +4 more sources
Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants
Advanced Science, EarlyView.Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer +17 more
wiley +1 more source
Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
Advanced Science, EarlyView.Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu +8 more
wiley +1 more source
Advanced Science, EarlyView.IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia +8 more
wiley +1 more source
Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy
Advanced Science, EarlyView.A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao +10 more
wiley +1 more source
Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma
Advanced Science, EarlyView.Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul +4 more
wiley +1 more source
The Specificity of Cathepsin D
Journal of Biological Chemistry, 1973 Abstract Bovine spleen cathepsin D has been partially purified for studies of its specificity. Isoelectric focusing of the purest preparation obtained indicated the presence of three molecular forms having approximately the same specific activity, but differing in their isoelectric points.
J B, Ferguson +3 more
openaire +2 more sources
Advanced Science, EarlyView.A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian +14 more
wiley +1 more source