Results 11 to 20 of about 20,584 (256)
Cathepsins B, D, and G Are Expressed in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma
Frontiers in Oncology, 2021 AimWe have previously demonstrated the presence of two cancer stem cell (CSC) subpopulations within metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC) expressing components of the renin-angiotensin system (RAS), which promotes ...
Felix Humphries +8 more
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Marine Drugs, 2022 Cathepsins are lysosomal cysteine proteases belonging to the papain family and play crucial roles in intracellular protein degradation/turnover, hormone maturation, antigen processing, and immune responses.
Yuqing Li +7 more
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Cancer Stem Cells in Head and Neck Cutaneous Squamous Cell Carcinoma Express Cathepsins
Plastic and Reconstructive Surgery, Global Open, 2020 Background:. Cancer stem cell (CSC) subpopulations within moderately differentiated head and neck cutaneous squamous cell carcinoma (MDHNcSCC) express the components of the renin–angiotensin system (RAS).
Therese Featherston, BBiomedSc(Hons) +8 more
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The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management
Cells, 2020 Cathepsins are the most abundant lysosomal proteases that are mainly found in acidicendo/lysosomal compartments where they play a vital role in intracellular protein degradation,energy metabolism, and immune responses among a host of other functions. The
Tulasi Yadati +3 more
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Expression and Localization of Cathepsins B, D, and G in Dupuytren’s Disease
Plastic and Reconstructive Surgery, Global Open, 2018 Background:. The pathogenesis of Dupuytren’s disease (DD) remains unclear. An embryonic stem cell (ESC)–like population in the endothelium of the microvessels around tissues that expresses components of the renin-angiotensin system (RAS) has been ...
Kirin Tan, MB ChB +7 more
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Translational Neurodegeneration, 2023 Background Lysosomal dysfunction has been implicated in a number of neurodegenerative diseases such as Parkinson’s disease (PD). Various molecular, clinical and genetic studies have highlighted a central role of lysosomal pathways and proteins in the ...
Alice Drobny +11 more
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Cathepsins in oral diseases: mechanisms and therapeutic implications
Frontiers in Immunology, 2023 Cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis.
Hao Jiang +6 more
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Human cysteine cathepsins are not reliable markers of infection by Pseudomonas aeruginosa in cystic fibrosis. [PDF]
PLoS ONE, 2011 Cysteine cathepsins have emerged as new players in inflammatory lung disorders. Their activities are dramatically increased in the sputum of cystic fibrosis (CF) patients, suggesting that they are involved in the pathophysiology of CF.
Clément Naudin +9 more
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In silico analysis of cysteine cathepsins identified from the transcriptome profile of blunt snout bream (Megalobrama amblycephala) [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2018 Cysteine cathepsins are described as lysosomal proteases with housekeeping and highly specialised functions in many organisms. In this study, cysteine cathepsins were identified from the transcriptome profile of blunt snout bream (Megalobrama ...
Ngoc Tuan Tran, Wei-Min Wang
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New Insights into the Role of Cysteine Cathepsins in Neuroinflammation
Biomolecules, 2021 Neuroinflammation, which is mediated by microglia and astrocytes, is associated with the progression of neurodegenerative diseases. Increasing evidence shows that activated microglia induce the expression and secretion of various lysosomal cathepsins ...
Anja Pišlar, Lara Bolčina, Janko Kos
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