Cysteine Cathepsins in Tumor-Associated Immune Cells [PDF]
Frontiers in Immunology, 2019 Cysteine cathepsins are key regulators of the innate and adaptive arms of the immune system. Their expression, activity, and subcellular localization are associated with the distinct development and differentiation stages of immune cells.
Tanja Jakoš +4 more
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Cysteine Cathepsins as Therapeutic Targets in Immune Regulation and Immune Disorders [PDF]
Biomedicines, 2023 Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital role in several processes—such as protein degradation, changes in cell signaling, cell morphology, migration and proliferation, and energy metabolism. In addition to
Emanuela Senjor +2 more
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Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins [PDF]
Communications Biology, 2023 Addressing the elusive specificity of cysteine cathepsins, which in contrast to caspases and trypsin-like proteases lack strict specificity determining P1 pocket, calls for innovative approaches. Proteomic analysis of cell lysates with human cathepsins K,
Livija Tušar +16 more
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New Insights into the Role of Cysteine Cathepsins in Neuroinflammation [PDF]
Biomolecules, 2021 Neuroinflammation, which is mediated by microglia and astrocytes, is associated with the progression of neurodegenerative diseases. Increasing evidence shows that activated microglia induce the expression and secretion of various lysosomal cathepsins ...
Anja Pišlar, Lara Bolčina, Janko Kos
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The Interplay of Glycosaminoglycans and Cysteine Cathepsins in Mucopolysaccharidosis [PDF]
Biomedicines, 2023 Mucopolysaccharidosis (MPS) consists of a group of inherited lysosomal storage disorders that are caused by a defect of certain enzymes that participate in the metabolism of glycosaminoglycans (GAGs).
Alexis David +4 more
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Cysteine Cathepsin Activity Regulation by Glycosaminoglycans [PDF]
BioMed Research International, 2014 Cysteine cathepsins are a group of enzymes normally found in the endolysosomes where they are primarily involved in intracellular protein turnover but also have a critical role in MHC II-mediated antigen processing and presentation. However, in a number of pathologies cysteine cathepsins were found to be heavily upregulated and secreted into ...
Marko Novinec +2 more
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Cysteine Cathepsins and Their Extracellular Roles: Shaping the Microenvironment [PDF]
Cells, 2019 For a long time, cysteine cathepsins were considered primarily as proteases crucial for nonspecific bulk proteolysis in the endolysosomal system. However, this view has dramatically changed, and cathepsins are now considered key players in many important
Eva Vidak +3 more
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Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells [PDF]
Frontiers in Immunology, 2014 Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. Some, such as cathepsins B, L and H are expressed constitutively in most immune cells.
Janko eKos +3 more
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Cysteine Cathepsins in Breast Cancer: Promising Targets for Fluorescence-Guided Surgery. [PDF]
Mol Imaging Biol, 2023 AbstractThe majority of breast cancer patients is treated with breast-conserving surgery (BCS) combined with adjuvant radiation therapy. Up to 40% of patients has a tumor-positive resection margin after BCS, which necessitates re-resection or additional boost radiation.
Linders DGJ +12 more
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Redundancy between Cysteine Cathepsins in Murine Experimental Autoimmune Encephalomyelitis. [PDF]
PLoS ONE, 2015 The cysteine cathepsins B, S, and L are functionally linked to antigen processing, and hence to autoimmune disorders such as multiple sclerosis. Stemming from several studies that demonstrate that mice can be protected from experimental autoimmune ...
Euan Ramsay Orr Allan +1 more
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