Results 1 to 10 of about 10,373 (179)

Cysteine cathepsins in human cancer

Biological Chemistry, 2004
AbstractProteases play causal roles in the malignant progression of human tumors. This review centers on the roles in this process of cysteine cathepsins, i.e., peptidases belonging to the papain family (C1) of the CA clan of cysteine proteases. Cysteine cathepsins, most likely along with matrix metalloproteases (MMPs) and serine proteases, degrade the
Bonnie F Sloane
exaly   +3 more sources

Chlorhexidine Inhibits the Activity of Dental Cysteine Cathepsins

Journal of Dental Research, 2012
The co-expression of MMPs and cysteine cathepsins in the human dentin-pulp complex indicates that both classes of enzymes can contribute to the endogenous proteolytic activity of dentin. Chlorhexidine (CHX) is an efficient inhibitor of MMP activity. This study investigated whether CHX could also inhibit cysteine cathepsins present in dentin.
Polliana Mendes Candia Scaffa, N Barros, Adriana K Carmona   +2 more
exaly   +5 more sources

Cysteine cathepsins: Cellular roadmap to different functions

Biochimie, 2008
Cysteine cathepsins belong to the papain-like family C1 of clan CA cysteine peptidases. These enzymes are ubiquitously expressed and exert their proteolytic activity mainly, but not exclusively within the compartments along the endocytic pathway. Moreover, cysteine cathepsins are active in pericellular environments as soluble enzymes or bound to cell ...
Klaudia Brix, Silvia Jordans
exaly   +3 more sources

Cysteine cathepsins: A long and winding road towards clinics

Molecular Aspects of Medicine, 2022
Boris Türk
exaly  

Cysteine cathepsins: Their biological and molecular significance in cancer stem cells

Seminars in Cancer Biology, 2018
Anja Pišlar, Anahid Jewett, Janko Koß   +2 more
exaly  

Dual contrasting roles of cysteine cathepsins in cancer progression: Apoptosis versus tumour invasion

Biochimie, 2008
Olga Vasiljeva, Boris Türk
exaly  

Role for Cysteine Protease Cathepsins in Heart Disease

Circulation, 2012
Xian Wu Cheng, Guo-Ping Shi, Masafumi Kuzuya   +2 more
exaly  

Cysteine cathepsins in extracellular matrix remodeling: Extracellular matrix degradation and beyond

Matrix Biology, 2019
Matej Vizovisek, Marko Fonović, Boris Türk   +2 more
exaly  

The inhibitory effects of silver diamine fluorides on cysteine cathepsins

Journal of Dentistry, 2014
May Lei Mei, Chun Hung Chu, Edward C M Lo   +2 more
exaly  

Cysteine Cathepsins: Potential Applications in Diagnostics and Therapy of Malignant Tumors

Biochemistry (Moscow), 2019
Lyudmila V Savvateeva, Dmitry O Korolev, Andrey A Zamyatnin   +2 more
exaly