Results 21 to 30 of about 10,373 (179)
Probing the activity of cysteine cathepsins in inflammatory bowel diseases [PDF]
Scientific ReportsCathepsin S is a cysteine protease that has been implicated in inflammatory bowel diseases (IBD) for its ability to promote visceral pain. Given its pro-inflammatory roles, we hypothesized that cathepsin S would drive other symptoms associated with IBD ...
Bethany M. Anderson +13 more
doaj +2 more sources
Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants. [PDF]
Int J Mol Sci, 2020 Besides their primary involvement in the recycling and degradation of proteins in endo-lysosomal compartments but also in specialized biological functions, cysteine cathepsins are pivotal proteolytic contributors of various deleterious diseases. While the molecular mechanisms of regulation by their natural inhibitors have been exhaustively studied ...
Lalmanach G +5 more
europepmc +6 more sources
Cysteine Cathepsins Inhibition Affects Their Expression and Human Renal Cancer Cell Phenotype [PDF]
Cancers, 2020 Magdalena Rudzinska +2 more
exaly +2 more sources
Shaping the Immune Response: Cathepsins in Virus-Dendritic Cell Interactions [PDF]
CellsDendritic cells (DCs) are among the first immune cells to detect viral invasion and play a central role in initiating and shaping antiviral immune responses.
Adrianna Niedzielska +5 more
doaj +2 more sources
Molecular probes for selective detection of cysteine cathepsins. [PDF]
Org Biomol Chem, 2021 One of these is not like the others: the 11 cysteine cathepsins have overlapping but distinct roles in pathology, and molecular probes enable their cumulative or selective detection in many applications.
Schleyer KA, Cui L.
europepmc +3 more sources
Frontiers in Immunology, 2021 Cysteine cathepsins are primarily involved in the degradation and recycling of proteins in endo-lysosomal compartments but are also gaining recognition as pivotal proteolytic contributors to various immune functions.
Milica Perišić Nanut +4 more
doaj +1 more source
In silico analysis of cysteine cathepsins identified from the transcriptome profile of blunt snout bream (Megalobrama amblycephala) [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2018 Cysteine cathepsins are described as lysosomal proteases with housekeeping and highly specialised functions in many organisms. In this study, cysteine cathepsins were identified from the transcriptome profile of blunt snout bream (Megalobrama ...
Ngoc Tuan Tran, Wei-Min Wang
doaj +1 more source
The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara +2 more
doaj +1 more source
Cysteine cathepsins in human carious dentin. [PDF]
J Dent Res, 2011 Matrix metalloproteinases (MMPs) are important in dentinal caries, and analysis of recent data demonstrates the presence of other collagen-degrading enzymes, cysteine cathepsins, in human dentin. This study aimed to examine the presence, source, and activity of cysteine cathepsins in human caries. Cathepsin B was detected with immunostaining.
Nascimento FD +9 more
europepmc +4 more sources
Multiple Roles for Cysteine Cathepsins in Cancer [PDF]
Cell Cycle, 2004 Cysteine cathepsins are a family of proteases that have recently emerged as important players in cancer, and have variously been reported to be involved in apoptosis, angiogenesis, cell proliferation, and invasion. In normal cells, cysteine cathepsins are typically localized in lysosomes and other intracellular compartments, and are involved in protein
Johanna A, Joyce, Douglas, Hanahan
openaire +2 more sources