Results 1 to 10 of about 143,104 (208)
Frontiers in Pharmacology, 2023 Aberrant activity of the cysteine protease Cathepsin S (CTSS) has been implicated across a wide range of pathologies. Notably in cancer, CTSS has been shown to promote tumour progression, primarily through facilitating invasion and migration of tumour ...
P. Smyth +12 more
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Cathepsins in oral diseases: mechanisms and therapeutic implications
Frontiers in Immunology, 2023 Cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis.
Hao Jiang +6 more
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Improved Cathepsin Probes for Sensitive Molecular Imaging
Molecules, 2022 Cysteine cathepsin proteases are found under normal conditions in the lysosomal compartments of cells, where they play pivotal roles in a variety of cellular processes such as protein and lipid metabolism, autophagy, antigen presentation, and cell growth
Yonit Yitzhak +5 more
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Cathepsins B, D, and G Are Expressed in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma
Frontiers in Oncology, 2021 AimWe have previously demonstrated the presence of two cancer stem cell (CSC) subpopulations within metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC) expressing components of the renin-angiotensin system (RAS), which promotes ...
Felix Humphries +8 more
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Marine Drugs, 2022 Cathepsins are lysosomal cysteine proteases belonging to the papain family and play crucial roles in intracellular protein degradation/turnover, hormone maturation, antigen processing, and immune responses.
Yuqing Li +7 more
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Biomedicines, 2022 Inflammation plays a vital role in regulating fibrotic processes. Beside their classical role in extracellular matrix synthesis and remodeling, fibroblasts act as immune sentinel cells participating in regulating immune responses.
Thanh-Diep Ly +8 more
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Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]
, 2020 Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I +3 more
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Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosis
Exploration of Digestive Diseases, 2023 Lysosomal hydrolases were once considered effectors of the waste disposal system of the cell, the endo-lysosomal system. However, they are now recognized as highly selective enzymes, which can modulate the function of several substrates, contributing to ...
Paloma Ruiz-Blázquez +2 more
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Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin [PDF]
, 2002 Besides its physiological role in lysosomal protein breakdown, extralysosomal cathepsin B has recently been implicated in apoptotic cell death. Highly specific irreversible cathepsin B inhibitors that are readily cellpermeant should be useful tools to ...
Assfalg-Machleidt, Irmgard +5 more
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Expression of a barley cystatin gene in maize enhances resistance against phytophagous mites by altering their cysteine-proteases [PDF]
, 2011 Phytocystatins are inhibitors of cysteine-proteases from plants putatively involved in plant defence based on their capability of inhibit heterologous enzymes.
A Kiggundu +49 more
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