Results 1 to 10 of about 80,420 (119)

The role of inflammation in the immune evasion of KRas [PDF]

Frontiers in Immunology
KRas, NRas and HRas mutations are recognized in over 25% of all tumors, with the predominant mutations occurring at amino acids G12 or G13. While small molecule inhibitors of KRas show therapeutic promise, KRas has largely resisted control by ...
E. Jane Homan, Robert D. Bremel
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Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy

Frontiers in Pharmacology, 2023
Aberrant activity of the cysteine protease Cathepsin S (CTSS) has been implicated across a wide range of pathologies. Notably in cancer, CTSS has been shown to promote tumour progression, primarily through facilitating invasion and migration of tumour ...
P. Smyth, L. Ferguson, J. F. Burrows, R. E. Burden, S. R. Tracey, Ú. M. Herron, M. Kovaleva, R. Williams, A. J. Porter, A. J. Porter, D. B. Longley, C. J. Barelle, C. J. Scott   +12 more
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Cathepsins in oral diseases: mechanisms and therapeutic implications

Frontiers in Immunology, 2023
Cathepsins are a type of lysosomal globulin hydrolase and are crucial for many physiological processes, including the resorption of bone matrix, innate immunity, apoptosis, proliferation, metastasis, autophagy, and angiogenesis.
Hao Jiang, Hao Jiang, Zuoxiang Dong, Xiaomin Xia, Xiaomin Xia, Xue Li, Xue Li   +6 more
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Improved Cathepsin Probes for Sensitive Molecular Imaging

Molecules, 2022
Cysteine cathepsin proteases are found under normal conditions in the lysosomal compartments of cells, where they play pivotal roles in a variety of cellular processes such as protein and lipid metabolism, autophagy, antigen presentation, and cell growth
Yonit Yitzhak, Hanmant Gaikwad, Tommy Weiss-Sadan, Emmanuelle Merquiol, Boris Turk, Galia Blum   +5 more
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Cathepsins B, D, and G Are Expressed in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma

Frontiers in Oncology, 2021
AimWe have previously demonstrated the presence of two cancer stem cell (CSC) subpopulations within metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC) expressing components of the renin-angiotensin system (RAS), which promotes ...
Felix Humphries, Bridget Chang-McDonald, Josie Patel, Nicholas Bockett, Erin Paterson, Paul F. Davis, Swee T. Tan, Swee T. Tan, Swee T. Tan   +8 more
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Muscle Quality of Sword Prawn (Parapenaeopsis hardwickii) during Cold Storage Based on Changes of Endogenous Enzyme Activity

Shipin gongye ke-ji, 2022
Objective: To investigate the changes of endogenous enzyme activity and muscle quality characteristics of Sword prawn (Parapenaeopsis hardwickii) under cold storage. Methods: Sword prawn (Parapenaeopsis hardwickii) was taken as the research object.
Ting ZHOU, Shanshan SHUI, Zhipeng LI, Yingru WU, Yixuan DING, Bin ZHANG   +5 more
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Cleavage of Occludin by Cigarette Smoke-Elicited Cathepsin S Increases Permeability of Lung Epithelial Cells

Antioxidants, 2022
Background. Chronic obstructive pulmonary disease (COPD) is an irreversible disease mainly caused by smoking. COPD is characterized by emphysema and chronic bronchitis associated with enhanced epithelial permeability. Hypothesis.
Paul Bigot, Simon Chesseron, Ahlame Saidi, Damien Sizaret, Christelle Parent, Agnès Petit-Courty, Yves Courty, Fabien Lecaille, Gilles Lalmanach   +8 more
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Cathepsins in oral diseases

Journal of Dr. NTR University of Health Sciences, 2019
Cathepsins are a class of globular lysosomal proteases known to be responsible for protein degradation. In addition to proteolysis they have many biological roles such as apoptosis wound healing angiogenesis, proenzymatic activation, bone remodelling and
K Ajay Benarji, K Roja Lakshmi, Hasini Nelakurthi, Pothuraju Haritha, Rudraraju Amrutha   +4 more
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Cathepsin K maintains the compartment of bone marrow T lymphocytes in vivo

Immunity, Inflammation and Disease, 2021
In this study, we investigated the influence of the loss of cathepsin K (Ctsk) gene on the hematopoietic system in vitro and in vivo. We found that cultures with lineage− SCA1+ KIT+ (LSK) cells on Ctsk deficient stromal cells display reduced colony ...
Renate Hausinger, Marianne Hackl, Ana Jardon Alvarez, Miriam Kehr, Sandra Romero Marquez, Franziska Hettler, Christian Kehr, Sandra Grziwok, Christina Schreck, Christian Peschel, Rouzanna Istvánffy, Robert A. J. Oostendorp   +11 more
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Zymography of proteases in honey bees (Apis Mellifera) infected with Nosema ceranae [PDF]

Veterinarski Glasnik
Nosemosis is one of the most important honey bee diseases and is caused by two fungal species of the genus Nosema, i.e., Nosema apis and Nosema ceranae.
Doghuzlu Mohammad Afrasiabi, Nabian Sedigheh, Paghaleh Gholam Ali Nehzati, Taheri Mohammad, Asadollahi Zahra, Akhzari Soheila   +5 more
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