Results 41 to 50 of about 94,483 (310)
Lysosomal Biology and Function: Modern View of Cellular Debris Bin
Cells, 2020 Lysosomes are the main proteolytic compartments of mammalian cells comprising of a battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular macromolecules by fusing with endosomes or autophagosomes through specific waste ...
Purvi C. Trivedi +2 more
doaj +1 more source
Cathepsin K maintains the compartment of bone marrow T lymphocytes in vivo
Immunity, Inflammation and Disease, 2021 In this study, we investigated the influence of the loss of cathepsin K (Ctsk) gene on the hematopoietic system in vitro and in vivo. We found that cultures with lineage− SCA1+ KIT+ (LSK) cells on Ctsk deficient stromal cells display reduced colony ...
Renate Hausinger +11 more
doaj +1 more source
Yeast as a tool to explore cathepsin D function [PDF]
, 2015 Cathepsin D has garnered increased attention in recent years, mainly since it has been associated with several human pathologies. In particular, cathepsin D is often overexpressed and hypersecreted in cancer cells, implying it may ...
C.S.F. Oliveira +11 more
core +1 more source
Proteolytic enzymes of pond fish: methods of isolation and properties
Известия ТИНРО, 2016 Methods of proteolytic enzymes isolation from muscle tissue and viscera of pond fish are viewed and their properties are investigated. Efficiency of enzymatic processes is determined by physical and chemical characteristics of the enzymes and, first of ...
Olga P. Dvoryaninova +2 more
doaj +1 more source
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis. [PDF]
, 2014 Most African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal
Sam Alsford, Alsford, Sam
core +1 more source
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Frontiers in Neurology, 2017 BackgroundAlexander disease (AxD) is a rare disease caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). The disease is characterized by presence of GFAP aggregates in the cytoplasm of astrocytes and loss of myelin ...
Ulises Gómez-Pinedo +4 more
doaj +1 more source
Lysosomal-Cleavable Peptide Linkers in Antibody–Drug Conjugates
Biomedicines, 2023 Antibody–drug Conjugates (ADCs) are a powerful therapeutic modality for cancer treatment. ADCs are multi-functional biologics in which a disease-targeting antibody is conjugated to an effector payload molecule via a linker.
Seetharamsing Balamkundu, Chuan-Fa Liu
doaj +1 more source
Characterization of cathepsins in cartilage [PDF]
Biochemical Journal, 1967 The presence of a cathepsin B-like enzyme in rabbit ear cartilage was established by the use of the synthetic substrates benzoyl-l-arginine amide and benzoyl-dl-arginine 2-naphthylamide. This was facilitated by using a technique that permits the incubation of a fixed weight of thin (18μ) cartilage sections with an appropriate exogenous substrate.
S Y, Ali +3 more
openaire +2 more sources