Results 21 to 30 of about 102,381 (252)

TNF Family Cytokines Induce Distinct Cell Death Modalities in the A549 Human Lung Epithelial Cell Line when Administered in Combination with Ricin Toxin

Toxins, 2019
Ricin is a member of the ribosome-inactivating protein (RIP) family of toxins and is classified as a biothreat agent by the Centers for Disease Control and Prevention (CDC).
Alexa L. Hodges, Cody G. Kempen, William D. McCaig, Cory A. Parker, Nicholas J. Mantis, Timothy J. LaRocca   +5 more
doaj   +1 more source

Cathepsin B Protease Facilitates Chikungunya Virus Envelope Protein-Mediated Infection Via Endocytosis or Macropinocytosis [PDF]

, 2020
Chikungunya virus (CHIKV) is an enveloped virus that enters host cells and transits within the endosomes before starting its replication cycle, the precise mechanism of which is yet to be elucidated.
Izumida, Mai, Kubo, Yoshinao, Atsushi Tanaka, Hideki Hayashi, Hayashi, Hideki, Mai Izumida, Tanaka, Atsushi, Yoshinao Kubo   +7 more
core   +1 more source

Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis [PDF]

, 2011
Mutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of
Koch, Sabine, Cooper, Jonathan D, Svetlana M. Molchanova, Taira, Tomi, Tyynelä, Jaana, Jonathan D. Cooper, Ann K. Wright, Thomas H. Gillingwater, Sabine Koch, Andrew Edwards, Wright, Ann K, Gillingwater, Thomas H, Molchanova, Svetlana M, Jaana Tyynelä, Edwards, Andrew, Tomi Taira   +15 more
core   +1 more source

The role of lysosomal peptidases in glioma immune escape: underlying mechanisms and therapeutic strategies

Frontiers in Immunology, 2023
Glioblastoma is the most common primary malignant tumor of the central nervous system, which has the characteristics of strong invasion, frequent recurrence, and rapid progression.
Hao Liu, Hao Liu, Jie Peng, Jie Peng, Linzhen Huang, Dong Ruan, Yuguang Li, Fan Yuan, Zewei Tu, Zewei Tu, Zewei Tu, Zewei Tu, Kai Huang, Kai Huang, Kai Huang, Kai Huang, Xingen Zhu, Xingen Zhu, Xingen Zhu, Xingen Zhu   +19 more
doaj   +1 more source

Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells. [PDF]

, 2009
Recently it has been reported that a cathepsin B inhibitor, CA-074Me, attenuates ecotropic murine leukemia virus (Eco-MLV) infection in NIH3T3 cells, suggesting that cathepsin B is required for the Eco-MLV infection.
Oishi, Kazunori, Yamamoto, Naoki, Tsutomu Mizota, Kazunori Oishi, Nobuhiko Katunuma, Kensuke Goto, Minematsu, Kazuo, Goto, Kensuke, Haruka Kamiyama, Naoki Yamamoto, Hiroaki Yoshii, Kubo, Yoshinao, Katunuma, Nobuhiko, Yoshii, Hiroaki, Kamiyama, Haruka, Mizota, Tsutomu, Kazuo Minematsu, Yoshinao Kubo   +17 more
core   +1 more source

Elevated CTSL Gene Expression Correlated with Proinflammatory Cytokines in Omental Adipose Tissue of Patients with Obesity

Diabetes, Metabolic Syndrome and Obesity, 2022
Qiong Zhou,1,2 Yankun Zhu,3 Chun Li,2 Zhiqiang Li,1 Zhe Tang,2 Baohong Yuan,3 Xiaodan Wang,4 Shengqingyu Zhang,1 Xinan Wu1 1School of Public Health, Kunming Medical University, Kunming, People’s Republic of China; 2Department of Endocrinology, Yan’an ...
Zhou Q, Zhu Y, Li C, Li Z, Tang Z, Yuan B, Wang X, Zhang S, Wu X   +8 more
doaj  

Toxoplasma Cathepsin Protease B and Aspartyl Protease 1 Are Dispensable for Endolysosomal Protein Digestion

mSphere, 2020
The lysosome-like vacuolar compartment (VAC) is a major site of proteolysis in the intracellular parasite Toxoplasma gondii. Previous studies have shown that genetic ablation of a VAC-residing cysteine protease, cathepsin protease L (CPL), resulted in ...
Christian McDonald, David Smith, Manlio Di Cristina, Geetha Kannan, Zhicheng Dou, Vern B. Carruthers   +5 more
doaj   +1 more source

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. [PDF]

, 2014
Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Currier, Rachel B., Taane G Clark, Horn, David, José Afonso Guerra-Assunção, Clark, Taane G., Sam Alsford, Taane G. Clark (106263), David Horn (24969), Alsford, Sam, Rachel B Currier, Rachel B. Currier (144838), Guerra-Assunção, José Afonso, Currier, Rachel B, Horn, David; id_orcid, José Afonso Guerra-Assunção (166779), Guerra-Assunção, Jose Alfonso, Sam Alsford (24967), David Horn, Clark, Taane G   +18 more
core   +1 more source

Expression of Cathepsins B, D, and G in Isocitrate Dehydrogenase-Wildtype Glioblastoma

Frontiers in Surgery, 2017
AimTo investigate the expression of cathepsins B, D, and G, in relation to the cancer stem cell (CSC) subpopulations, we have previously characterized within isocitrate dehydogenase (IDH)-wildtype glioblastoma (IDHWGB).Methods3,3-Diaminobezidine (DAB ...
Sabrina P. Koh, Agadha C. Wickremesekera, Agadha C. Wickremesekera, Helen D. Brasch, Reginald Marsh, Swee T. Tan, Swee T. Tan, Tinte Itinteang   +7 more
doaj   +1 more source

Gallic Acid Reduces Experimental Colitis in Rats by Downregulation of Cathepsin and Oxidative Stress

Erciyes Medical Journal, 2020
Objective: Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease (IBD) with common, repetitive inflammation of the colon and rectum, which is highly defined by loss of blood on colon mucosa, ulceration and acute inflammation.
Gökhan Bayramoğlu, Hakan Şentürk, Güngör Kanbak, Mediha Canbek, Ayşegül Bayramoğlu, Eda Dokumacıoğlu, Selin Engür   +6 more
doaj   +1 more source