Results 31 to 40 of about 102,381 (252)

Identification of proteases employed by dendritic cells in the processing of protein purified derivative (PPD) [PDF]

, 2004
Dendritic cells (DC) are known to present exogenous protein Ag effectively to T cells. In this study we sought to identify the proteases that DC employ during antigen processing.
Mansour Mohamadzadeh, Brammer, Melissa, Luftig, Ronald B., Sestak, Karol, Melissa Brammer, Karol Sestak, Ronald B Luftig, Mohamadzadeh, Hamid, Hamid Mohamadzadeh, Mohamadzadeh, Mansour   +9 more
core   +1 more source

Cloning of a cDNA encoding Schistosoma mansoni cathepsin C and expression in the yeast Pichia pastoris [PDF]

, 2003
The cDNA encoding the proenzyme of cathepsin C from the parasitic helminth Schistosoma mansoni was amplified from a cDNA library using 5’ and 3’ specific primers containing sites for SnaBI and Avrll digestion.
Carty, Charlene
core   +2 more sources

Caspase-Mediated Cleavage of Human Cortactin during Influenza A Virus Infection Occurs in Its Actin-Binding Domains and Is Associated with Released Virus Titres

Viruses, 2020
Influenza A virus (IAV) exploits host factors to multiply and cause disease. An in-depth knowledge of this interaction of IAV with the host will aid the development of anti-IAV intervention strategies.
Da-Yuan Chen, Matloob Husain
doaj   +1 more source

Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. [PDF]

, 2011
Behavioral endophenotypes are determined by a multitude of counteracting but precisely balanced molecular and physiological mechanisms. In this study, we aim to identify potential novel molecular targets that contribute to the multigenic trait "anxiety".
Holsboer, Florian, Pütz Benno, Graf Cornelia, Peters, C., Bunck, Mirjam, Rieder, G., Steiner, Andrea, Baur Laura A., Mirjam Bunck, Markus Panhuysen, Rieder, Gabriele, Benno Pütz, Gabriele Rieder, Pütz, Benno, Claudia Kühne, Czibere Ludwig, Deussing, Jan, Laura A Baur, Weber Peter, Bunck, M., Peters, Christoph, Holsboer Florian, Graf, C., Czibere, L., Gemmeke, K., Cornelia Graf, Nafees Ahmad, Laura A. Baur, Widner, R., Graf, Cornelia, Hambsch Boris, Wittmann, A., Hambsch, B., Christoph Peters, Steiner Andrea, Peters Christoph, Weber, Peter, Ahmad, Nafees H.M., Wittmann, Anke, Kühne, C., Widner Regina, Panhuysen Markus, Landgraf Rainer, Reinheckel Thomas, Ahmad, N., Katja Gemmeke, Bunck Mirjam, Ludwig Czibere, Ahmad Nafees, Boris Hambsch, Wittmann Anke, Peter Weber, Deussing, Jan M., Rieder Gabriele, Holsboer, F., Panhuysen, Markus, Andrea Steiner, Reinheckel, Thomas, Kühne Claudia, Hambsch, Boris, Gemmeke Katja, Baur, L., Kühne, Claudia, Weber, P., Gemmeke, Katja, Thomas Reinheckel, Czibere, Ludwig, Jan M Deussing, Widner, Regina, Deussing, J., Ahmad, Nafees, Rainer Landgraf, Anke Wittmann, Pütz, B., Landgraf, R., Reinheckel, T., Florian Holsboer, Baur, Laura A., Landgraf, Rainer, Deussing Jan M., Panhuysen, M., Jan M. Deussing, Steiner, A., Regina Widner   +83 more
core   +1 more source

Analysis of Resistance of Ebola Virus Glycoprotein-Driven Entry Against MDL28170, An Inhibitor of Cysteine Cathepsins

Pathogens, 2019
Ebola virus (EBOV) infection can cause severe and frequently fatal disease in human patients. The EBOV glycoprotein (GP) mediates viral entry into host cells.
Markus Hoffmann, Svenja Victoria Kaufmann, Carina Fischer, Wiebke Maurer, Anna-Sophie Moldenhauer, Stefan Pöhlmann   +5 more
doaj   +1 more source

Family C1 cysteine proteases: Biological diversity or redundancy? [PDF]

, 2003
Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes.
Nägler, D. K., Ménard, R., Ménard, Robert, Nägler, Dorit K.   +3 more
core   +1 more source

Exploring Extracellular Vesicles Biogenesis in Hypothalamic Cells through a Heavy Isotope Pulse/Trace Proteomic Approach

Cells, 2020
Studies have shown that the process of extracellular vesicles (EVs) secretion and lysosome status are linked. When the lysosome is under stress, the cells would secrete more EVs to maintain cellular homeostasis.
Chee Fan Tan, Hui San Teo, Jung Eun Park, Bamaprasad Dutta, Shun Wilford Tse, Melvin Khee-Shing Leow, Walter Wahli, Siu Kwan Sze   +7 more
doaj   +1 more source

Recombinant production and characterisation of two Fasciola hepatica cathepsin L proteases [PDF]

, 2005
The cysteine proteases of the liver fluke, Fasciola hepatica, are of great importance to the virulence of the organism. Previous work has established the involvement of these enzymes in catabolism, migration through host tissues and defence against host ...
Collins, Peter Raymond
core   +2 more sources

Investigating the role of cathepsins in breast cancer progression: a Mendelian randomization study

Frontiers in Oncology
BackgroundBreast cancer, a major threat to women’s health worldwide, has mechanisms of onset that remain unclear. Within the human lysosomal system, a class of enzymes known as cathepsins exhibit elevated expression levels in various malignant tumors ...
Shengyi Zhou, Shengyi Zhou, Shengyi Zhou, Yizhou Sun, Yizhou Sun, Wenzhang Zha, Wenzhang Zha, Guangjun Zhou, Guangjun Zhou   +8 more
doaj   +1 more source

Biomarkers Associated With Tumor Ki67 and Cathepsin L Gene Expression in Prostate Cancer Patients Participating in a Presurgical Weight Loss Trial

Frontiers in Oncology, 2020
Our previous presurgical weight loss trial among 40 prostate cancer patients found that rapid (but not slow) weight loss resulted in increased tumor Ki67 and Cathepsin L (CTSL) gene expression.
Andrew D. Frugé, Kristen S. Smith, Jennifer R. Bail, Soroush Rais-Bahrami, Soroush Rais-Bahrami, Soroush Rais-Bahrami, Wendy Demark-Wahnefried, Wendy Demark-Wahnefried   +7 more
doaj   +1 more source