Results 11 to 20 of about 94,483 (310)

Cathepsins in oral diseases

Journal of Dr. NTR University of Health Sciences, 2019
Cathepsins are a class of globular lysosomal proteases known to be responsible for protein degradation. In addition to proteolysis they have many biological roles such as apoptosis wound healing angiogenesis, proenzymatic activation, bone remodelling and
K Ajay Benarji, K Roja Lakshmi, Hasini Nelakurthi, Pothuraju Haritha, Rudraraju Amrutha   +4 more
doaj   +1 more source

A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci [PDF]

, 2011
The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1.
Francis, S. E., Calogero Tulone, Read, R. C., Sheila E. Francis, Mitchell, T.J., Read Robert C., Benny Chain, Marriott, Helen M, Deretic, V., Dockrell, David H, Marriott, H.M., Francis, Sheila E, Dockrell, David H., Whyte, M.K.B., Martin A. Bewley, Mitchell Timothy J., Timothy J Mitchell, Whyte, Moira K B, Kroemer, G., Chain, B., Moira K. B. Whyte, Helen M Marriott, Sheila E Francis, Tulone Calogero, Robert C Read, Bewley, M.A., Dockrell, D.H., Whyte Moira K. B., Whyte, Moira K. B., Marriott Helen M., Read, Robert C., Marriott, H. M., Chain, Benny, Tulone, C., Read, R.C., Mitchell, Timothy J., Whyte, Moira K.B., David H. Dockrell, Mitchell, Timothy J, Francis Sheila E., David H Dockrell, Kroemer, Guido, Moira K B Whyte, Marriott, Helen M., Chain Benny, Mitchell, T. J., Timothy J. Mitchell, Bewley, Martin A, Dockrell, D. H., Read, Robert C, Tulone, Calogero, Francis, S.E., Robert C. Read, Dockrell David H., Bewley, Martin A., Martin A Bewley, Helen M. Marriott, Bewley, M. A., Dockrell, David, Bewley Martin A., Whyte, M. K. B., Guido Kroemer, Francis, Sheila E., Kroemer Guido   +63 more
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Zymography of proteases in honey bees (Apis Mellifera) infected with Nosema ceranae [PDF]

Veterinarski Glasnik
Nosemosis is one of the most important honey bee diseases and is caused by two fungal species of the genus Nosema, i.e., Nosema apis and Nosema ceranae.
Doghuzlu Mohammad Afrasiabi, Nabian Sedigheh, Paghaleh Gholam Ali Nehzati, Taheri Mohammad, Asadollahi Zahra, Akhzari Soheila   +5 more
doaj   +1 more source

Low‐level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus

FEBS Open Bio, 2022
For a long time, lysosomes were purely seen as organelles in charge of garbage disposal within the cell. They destroy any cargo delivered into their lumen with a plethora of highly potent hydrolytic enzymes, including various proteases. In case of damage
Thomas Reinheckel, Martina Tholen
doaj   +1 more source

Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin [PDF]

, 2002
Schaschke N, Deluca D, Assfalg-Machleidt I, Hohneke C, Sommerhoff CP, Machleidt W. Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin.
Schaschke, Norbert, Assfalg-Machleidt, Irmgard, Schaschke, N., Deluca, D, Sommerhoff, C. P., Höhneke, C., Sommerhoff, CP, Machleidt, W., Assfalg-Machleidt, I, Machleidt, Werner, Deluca, D., Deluca, Dominga, Sommerhoff, Christian P., Assfalg-Machleidt, I., Hohneke, C, Höhneke, Clara, Machleidt, W   +16 more
core   +1 more source

Importance of lysosomal cysteine proteases in lung disease

Respiratory Research, 2000
The human lysosomal cysteine proteases are a family of 11 proteases whose members include cathepsins B, C, H, L, and S. The biology of these proteases was largely ignored for decades because of their lysosomal location and the belief that their function ...
Chapman Harold A, Wolters Paul J
doaj   +1 more source

Peptide synthesis by recombinant Fasciola hepatica cathepsin L1 [PDF]

, 2006
Synthesis of the tripeptide Z-Phe-Arg-SerNH2 has been accomplished by a recombinant cysteine protease, cathepsin L1 from liver fluke (Fasciola hepatica), using Z-Phe-Arg-OMe as acyl acceptor and SerNH2 as nucleophile in 0.1 M ammonium acetate pH 9.0–12.5%
Ruth, Deborah M., Ó Fágáin, Ciarán, McMahon, Gillian   +2 more
core   +1 more source

Cathepsin B Protease Facilitates Chikungunya Virus Envelope Protein-Mediated Infection Via Endocytosis or Macropinocytosis [PDF]

, 2020
Chikungunya virus (CHIKV) is an enveloped virus that enters host cells and transits within the endosomes before starting its replication cycle, the precise mechanism of which is yet to be elucidated.
Izumida, Mai, Kubo, Yoshinao, Atsushi Tanaka, Hideki Hayashi, Hayashi, Hideki, Mai Izumida, Tanaka, Atsushi, Yoshinao Kubo   +7 more
core   +1 more source

TNF Family Cytokines Induce Distinct Cell Death Modalities in the A549 Human Lung Epithelial Cell Line when Administered in Combination with Ricin Toxin

Toxins, 2019
Ricin is a member of the ribosome-inactivating protein (RIP) family of toxins and is classified as a biothreat agent by the Centers for Disease Control and Prevention (CDC).
Alexa L. Hodges, Cody G. Kempen, William D. McCaig, Cory A. Parker, Nicholas J. Mantis, Timothy J. LaRocca   +5 more
doaj   +1 more source

Synthesis and Molecular Docking of N,N′-[succinylbis(oxy)]dibenzamides as Inhibitors of Cathepsin S and Cathepsin K

Chemistry Proceedings, 2021
The reaction of interaction of benzhydroxamic and 4-nitrobenzhydroxamic acids with succinyl chloride, carried out in an acetonitrile medium during boiling, was studied. It was revealed that the result of the reaction is the formation of N,N′-[succinylbis(
Yulia A. Trukhanova, Boris Y. Lalaev, Anna A. Vakhnina   +2 more
doaj   +1 more source