Results 1 to 10 of about 13,410,021 (203)
Cancer Cell, 2022 How glucose metabolism remodels pro-tumor functions of tumor-associated macrophages (TAMs) needs further investigation. Here we show that M2-like TAMs bear the highest individual capacity to take up intratumoral glucose.
Qicong Shen
exaly +2 more sources
Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction
Frontiers in Cell and Developmental Biology, 2020 The mechanisms leading to NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome activation are still debated. It is well established that oligomerized NLRP3 interacts with apoptosis associated Speck-like protein containing a CARD ...
Angélique Chevriaux +17 more
doaj +2 more sources
Cathepsin B is an executioner of ferroptosis.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020 Ferroptosis is a necrotic form of cell death caused by inactivation of the glutathione system and uncontrolled iron-mediated lipid peroxidation.
P. Nagakannan +3 more
semanticscholar +4 more sources
Definitions, 2020 Cathepsin B (339 aa, ~38 kDa) is encoded by the human CTSB gene. This protein plays a role in proteolysis, immunity and the regulation of apoptosis.
semanticscholar +2 more sources
Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function
Cell Metabolism, 2016 SUMMARY Peripheral processes that mediate beneficial effects of exercise on the brain remain sparsely explored. Here we show that a muscle secretory factor, Cathepsin B (CTSB) protein, is important for cognitive benefits of running.
Hyo Youl Moon, Nirnath Sah, Emrah Duzel
exaly +2 more sources
Cell Reports, 2017 Summary: Triple-negative breast cancer (TNBC) is considered incurable with currently available treatments, highlighting the need for therapeutic targets and predictive biomarkers.
Kyung-Min Yang +14 more
doaj +2 more sources
Cathepsin B in human peripheral blood lymphocytes as a peripheral biomarker for cardiac hypertrophy [PDF]
Scientific ReportsPrevious studies have demonstrated that cathepsin B is up-regulated in the myocardium of both mice and humans with pathological cardiac hypertrophy. However, it remains unknown whether cathepsin B is detectable in human peripheral blood lymphocytes (PBLs)
Dandan Feng +8 more
doaj +2 more sources
Cathepsin B as a cancer target [PDF]
Expert Opinion on Therapeutic Targets, 2013 Cathepsin B is of significant importance to cancer therapy as it is involved in various pathologies and oncogenic processes in humans. Numerous studies have shown that abnormal regulation of cathepsin B overexpression is correlated with invasive and metastatic phenotypes in cancers.
Christopher S Gondi
exaly +3 more sources
Cathepsin B: Multiple roles in cancer
Proteomics - Clinical Applications, 2014 Proteases, including intracellular proteases, play roles at many different stages of malignant progression. Our focus here is cathepsin B, a lysosomal cysteine cathepsin.
Bonnie F Sloane
exaly +2 more sources
International Journal of Biological Markers, 2008 Numerous studies have linked cathepsins and their inhibitor cystatin C to tumor invasion and metastasis. We examined whether cathepsin B, cathepsin H, cathepsin X and cystatin C could be detected in sera from women with early-stage or inflammatory breast
Janko Kos, Julie Decock
exaly +2 more sources