Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection [PDF]
, 2016 Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic, and degenerative diseases in humans.
Gurung, Prajwal +9 more
core +1 more source
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CTSB (cathepsin B), with data on DNA, on the protein encoded, and where the gene is implicated.
Jevnikar, Z, Kos, J
openaire +2 more sources
Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis [PDF]
, 2015 International audienceAbstractThe activity of cysteine cathepsin B increased markedly in lung homogenates and in bronchoalveolar lavage fluids (BALF) of the mouse model of bleomycin-induced lung fibrosis after 14 days of challenge.
Couillin, Isabelle +7 more
core +3 more sources
The Role of Cathepsin B in Peritoneal Fibrosis due to Peritoneal Dialysis
International Journal of Nephrology, 2019 Glucose-containing peritoneal dialysis (PD) solution causes peritoneal fibrosis (PF) characterized by accumulation of extracellular matrix (ECM) in the submesothelial layer.
Su Ah Sung +4 more
doaj +1 more source
Autophagy is activated and involved in cell death with participation of cathepsins during stress-induced microspore embryogenesis in barley [PDF]
, 2018 Microspores are reprogrammed towards embryogenesis by stress. Many microspores die after this stress, limiting the efficiency of microspore embryogenesis. Autophagy is a degradation pathway that plays critical roles in stress response and cell death.
Berenguer, Eduardo +4 more
core +1 more source
Cathepsin B cleavage of the trypsinogen activation peptide
BMC Gastroenterology, 2002 Background Cathepsin B is thought to play a central role in intrapancreatic trypsinogen activation and the onset of pancreatitis. A recent investigation of the cathepsin B mediated activability of wildtype trypsinogen and their mutations N29I, N29T and ...
Keim Volker, Bödeker Hans, Teich Niels
doaj +1 more source
Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells [PDF]
, 2015 Sorafenib, a tyrosine kinase inhibitor, has been demonstrated to exert anti-tumor effects. However, the molecular mechanisms underlying its effects on bladder cancer remain unknown.
AMANTINI, Consuelo +11 more
core +3 more sources
Immune Mechanisms Involved in Schistosoma mansoni-Cathepsin B Vaccine Induced Protection in Mice
Frontiers in Immunology, 2018 A vaccine against schistosomiasis would contribute to a long-lasting decrease in disease spectrum and transmission. Our previous protection studies in mice using Schistosoma mansoni Cathepsin B (Sm-Cathepsin B) resulted in 59 and 60% worm burden ...
Alessandra Ricciardi +7 more
doaj +1 more source
Family C1 cysteine proteases: Biological diversity or redundancy? [PDF]
, 2003 Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes.
Brömme D. +4 more
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Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies [PDF]
Biological Chemistry, 2014 Abstract Cathepsin B has been demonstrated to be involved in several proteolytic processes that support tumor progression and metastasis and neurodegeneration. To further clarify its role, defined monoclonal antibodies are needed.
Weber, Ekkehard +7 more
openaire +3 more sources