Results 41 to 50 of about 25,778,187 (334)

Immune Mechanisms Involved in Schistosoma mansoni-Cathepsin B Vaccine Induced Protection in Mice

Frontiers in Immunology, 2018
A vaccine against schistosomiasis would contribute to a long-lasting decrease in disease spectrum and transmission. Our previous protection studies in mice using Schistosoma mansoni Cathepsin B (Sm-Cathepsin B) resulted in 59 and 60% worm burden ...
Alessandra Ricciardi, Alessandra Ricciardi, Nicholas H. Zelt, Nicholas H. Zelt, Kittipos Visitsunthorn, John P. Dalton, Momar Ndao, Momar Ndao   +7 more
doaj   +1 more source

Decreased MARCKS Protein Expression in Kidney Cortex Membrane Fractions of Cathepsin B Knockout Mice Is Associated with Reduced Lysophosphatidylcholine and Protein Kinase C Activity

Biomedicines, 2023
Cathpesin B is a multi-functional protease that plays numerous roles in physiology and pathophysiology. We hypothesized that actin cytoskeleton proteins that are substrates of cathepsin B, various lipids, and kinases that are regulated by lipids would be
Tamim Kawakibi, Niharika Bala, Lauren P. Liu, Louis A. Searcy, Nancy D. Denslow, Abdel A. Alli   +5 more
doaj   +1 more source

Cathepsin B cleavage of the trypsinogen activation peptide

BMC Gastroenterology, 2002
Background Cathepsin B is thought to play a central role in intrapancreatic trypsinogen activation and the onset of pancreatitis. A recent investigation of the cathepsin B mediated activability of wildtype trypsinogen and their mutations N29I, N29T and ...
Keim Volker, Bödeker Hans, Teich Niels
doaj   +1 more source

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. [PDF]

, 2014
Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Currier, Rachel B., Taane G Clark, Horn, David, José Afonso Guerra-Assunção, Clark, Taane G., Sam Alsford, Taane G. Clark (106263), David Horn (24969), Alsford, Sam, Rachel B Currier, Rachel B. Currier (144838), Guerra-Assunção, José Afonso, Currier, Rachel B, Horn, David; id_orcid, José Afonso Guerra-Assunção (166779), Guerra-Assunção, Jose Alfonso, Sam Alsford (24967), David Horn, Clark, Taane G   +18 more
core   +1 more source

Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. [PDF]

, 2011
Behavioral endophenotypes are determined by a multitude of counteracting but precisely balanced molecular and physiological mechanisms. In this study, we aim to identify potential novel molecular targets that contribute to the multigenic trait "anxiety".
Holsboer, Florian, Pütz Benno, Graf Cornelia, Peters, C., Bunck, Mirjam, Rieder, G., Steiner, Andrea, Baur Laura A., Mirjam Bunck, Markus Panhuysen, Rieder, Gabriele, Benno Pütz, Gabriele Rieder, Pütz, Benno, Claudia Kühne, Czibere Ludwig, Deussing, Jan, Laura A Baur, Weber Peter, Bunck, M., Peters, Christoph, Holsboer Florian, Graf, C., Czibere, L., Gemmeke, K., Cornelia Graf, Nafees Ahmad, Laura A. Baur, Widner, R., Graf, Cornelia, Hambsch Boris, Wittmann, A., Hambsch, B., Christoph Peters, Steiner Andrea, Peters Christoph, Weber, Peter, Ahmad, Nafees H.M., Wittmann, Anke, Kühne, C., Widner Regina, Panhuysen Markus, Landgraf Rainer, Reinheckel Thomas, Ahmad, N., Katja Gemmeke, Bunck Mirjam, Ludwig Czibere, Ahmad Nafees, Boris Hambsch, Wittmann Anke, Peter Weber, Deussing, Jan M., Rieder Gabriele, Holsboer, F., Panhuysen, Markus, Andrea Steiner, Reinheckel, Thomas, Kühne Claudia, Hambsch, Boris, Gemmeke Katja, Baur, L., Kühne, Claudia, Weber, P., Gemmeke, Katja, Thomas Reinheckel, Czibere, Ludwig, Jan M Deussing, Widner, Regina, Deussing, J., Ahmad, Nafees, Rainer Landgraf, Anke Wittmann, Pütz, B., Landgraf, R., Reinheckel, T., Florian Holsboer, Baur, Laura A., Landgraf, Rainer, Deussing Jan M., Panhuysen, M., Jan M. Deussing, Steiner, A., Regina Widner   +83 more
core   +1 more source

Cathepsin B: a sellsword of cancer progression

Cancer Letters, 2019
Clinical, biochemical and molecular biology studies have identified lysosome-encapsulated cellular proteases as critical risk factors for cancer progression.
O. Mijanović, Ana Branković, A. Panin, S. Savchuk, P. Timashev, I. Ulasov, M. Lesniak   +6 more
semanticscholar   +1 more source

Identification of proteases employed by dendritic cells in the processing of protein purified derivative (PPD) [PDF]

, 2004
Dendritic cells (DC) are known to present exogenous protein Ag effectively to T cells. In this study we sought to identify the proteases that DC employ during antigen processing.
Mansour Mohamadzadeh, Brammer, Melissa, Luftig, Ronald B., Sestak, Karol, Melissa Brammer, Karol Sestak, Ronald B Luftig, Mohamadzadeh, Hamid, Hamid Mohamadzadeh, Mohamadzadeh, Mansour   +9 more
core   +1 more source

Trimethylamine N-Oxide (TMAO) Inducing Endothelial Injury: UPLC-MS/MS-Based Quantification and the Activation of Cathepsin B-Mediated NLRP3 Inflammasome

Molecules, 2023
TMAO is a new risk biomarker for cardiovascular disease. With trimethylammonium as its main chemical skeleton, TMAO is structurally similar to many endogenous metabolites, such as acetylcholine, carnitine, phosphorylcholine, etc. The mechanism of TMAO on
Dongyu Lei, Wenbo Yu, Yi Liu, Yujie Jiang, Xiaohui Li, Jing Lv, Ying Li   +6 more
doaj   +1 more source

Cloning and analysis of cathepsin B gene of Radopholus similis

浙江大学学报. 农业与生命科学版, 2013
The banana burrowing nematode, Radopholus similis, is a migratory endoparasite plant nematode and severely harms many tropical and subtropical crops. It is the most important invasive species to banana worldwide, and is listed as a quarantine pest in ...
LI Danlei, LI Yu, XIE Hui, XU Chunling, Huang Xin   +4 more
doaj   +1 more source

Co-infection of TYLCV and ToCV increases cathepsin B and promotes ToCV transmission by Bemisia tabaci MED

Frontiers in Microbiology, 2023
Tomato disease is an important disease affecting agricultural production, and the combined infection of tomato chlorosis virus (ToCV) and tomato yellow leaf curl virus (TYLCV) has gradually expanded in recent years, but no effective control method has ...
Ding-Yi-Hui Lu, Ding-Yi-Hui Lu, Jin-Yu Liao, Anugerah Fajar, Anugerah Fajar, Jian-Bin Chen, Yan Wei, Zhan-Hong Zhang, Zhuo Zhang, Li-Min Zheng, Xin-Qiu Tan, Xu-Guo Zhou, Xiao-Bin Shi, Xiao-Bin Shi, Yong Liu, Yong Liu, De-Yong Zhang, De-Yong Zhang   +17 more
doaj   +1 more source