Results 21 to 30 of about 25,778,187 (334)

Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB [PDF]

, 2013
Cysteine proteases of the papain superfamily are present in nearly all eukaryotes. They play pivotal roles in the biology of parasites and inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as sleeping
Mottram, Jeremy C, Mottram Jeremy C., Richard J Marhöfer, Schröder Jörg, Selzer, P.M., Schroder, J., Noack, Sandra, Noack Sandra, Schröder, Jörg, Noack, S., Mottram, J.C., Sandra Noack, Coombs, G.H., Coombs, Graham H, Marhöfer, Richard J, Coombs Graham H., Paul M Selzer, Jeremy C Mottram, Marhöfer Richard J., Marhofer, R.J., Jörg Schröder, Selzer Paul M., Selzer, Paul M, Selzer, Paul M., Graham H Coombs   +24 more
core   +4 more sources

Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K

Molecules, 2023
Background: Cathepsin K, which is involved in bone resorption, is a good target for treating osteoporosis, but no clinically approved medicine has been developed.
Shun Sato, Kana Yamamoto, Moeno Ito, Katsutoshi Nishino, Takanao Otsuka, Kazuhiro Irie, Masaya Nagao   +6 more
doaj   +1 more source

Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice

Applied Sciences, 2022
The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk−/−) mice have learning and memory impairments.
Denise M. T. Yu, Stephanie Dauth, Michael B. Margineanu, Valentina Snetkova, Maren Rehders, Silvia Jordans, Klaudia Brix   +6 more
doaj   +1 more source

Human tumour cathepsin B. Comparison with normal liver cathepsin B [PDF]

Biochemical Journal, 1992
Cathepsin B was purified from normal human liver and several human tumour tissues and partially characterized. Three forms of cathepsin B, with molecular masses of 25 kDa, 26 kDa (the two appearing as a doublet) and 30 kDa, were detected in SDS/polyacrylamide gels.
Moin, K., Day, N., Sameni, M., Hasnain, Sadiq, Hirama, Tomoko, Sloane, B.   +5 more
openaire   +3 more sources

Development of a Peptide-Based Nano-Sized Cathepsin B Inhibitor for Anticancer Therapy

Pharmaceutics, 2023
Numerous cathepsin B inhibitors have been developed and are under investigation as potential cancer treatments. They have been evaluated for their ability to inhibit cathepsin B activity and reduce tumor growth.
So-Hyeon Park, Jun-Hyuck Lee, Seong-Bin Yang, Dong-Nyeong Lee, Tae-Bong Kang, Jooho Park   +5 more
doaj   +1 more source

Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8 [PDF]

, 2013
Cysteine protease B is considered crucial for the survival and infectivity of the Leishmania in its human host. Several microorganism pathogens bind to the heparin-like glycosaminoglycans chains of proteoglycans at host-cell surface to promote their ...
Gesteira, Tarsis F., Tarsis F Gesteira, Gesteira Tarsis F., Sanya J Sanderson, Tersariol, Ivarne L.S., Westrop, Gareth, Sansevero, Thiago M., Shida, Claudio S. [UNIFESP], Manfredi, Marcella A, Tersariol, Ivarne Luis dos Santos [UNIFESP], Gerson P Souza, Ivarne L S Tersariol, Luiz Juliano, Manfredi Marcella A., Gareth D Westrop, Sansevero Thiago M., Almeida Paulo C., Tersariol Ivarne L. S., Souza, Gerson A., Manfredi, Marcella A., Sanderson Sanya J., Thiago M Sansevero, Souza, Gerson P., Juliano, Luiz, Westrop, Gareth D., Almeida, Paulo C. [UNIFESP], Judice, W.A.S., Paulo C Almeida, Judice Wagner A. S., Coombs Graham H., Coombs, Graham H., Shida, Claudio S., Shida Cláudio S., Cláudio S Shida, Souza Gerson P., Almeida, Paulo C, Judice, Wagner A. S., Marcella A Manfredi, Sanderson, Sanya J, Coombs, Graham, Juliano, Luiz [UNIFESP], Wagner A S Judice, Juliano Luiz, Sanderson, Sanya J., Graham H Coombs, Westrop Gareth D.   +45 more
core   +4 more sources

Cathepsin B-Cleavable Polymeric Photosensitizer Prodrug for Selective Photodynamic Therapy: In Vitro Studies

Pharmaceuticals, 2022
Cathepsin B is a lysosomal cysteine protease that plays an important role in cancer, atherosclerosis, and other inflammatory diseases. The suppression of cathepsin B can inhibit tumor growth.
Manish Jain, Jordan Bouilloux, Ines Borrego, Stéphane Cook, Hubert van den Bergh, Norbert Lange, Georges Wagnieres, Marie-Noelle Giraud   +7 more
doaj   +1 more source

Cathepsin B in Neurodegeneration of Alzheimer’s Disease, Traumatic Brain Injury, and Related Brain Disorders

Biochimica et Biophysica Acta - Proteins and Proteomics, 2020
Investigations of Alzheimer’s disease (AD), traumatic brain injury (TBI), and related brain disorders have provided extensive evidence for involvement of cathepsin B, a lysosomal cysteine protease, in mediating the behavioral deficits and neuropathology ...
V. Hook, Michael C. Yoon, Charles Mosier, Gen Ito, Sonia Podvin, B. Head, Robert A. Rissman, A. O'Donoghue, Gregory R. Hook   +8 more
semanticscholar   +1 more source

Cathepsin B Protease Facilitates Chikungunya Virus Envelope Protein-Mediated Infection Via Endocytosis or Macropinocytosis [PDF]

, 2020
Chikungunya virus (CHIKV) is an enveloped virus that enters host cells and transits within the endosomes before starting its replication cycle, the precise mechanism of which is yet to be elucidated.
Izumida, Mai, Kubo, Yoshinao, Atsushi Tanaka, Hideki Hayashi, Hayashi, Hideki, Mai Izumida, Tanaka, Atsushi, Yoshinao Kubo   +7 more
core   +1 more source

Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment

Acta Pharmaceutica Sinica B, 2020
Multi-modal therapeutics are emerging for simultaneous diagnosis and treatment of cancer. Polymeric carriers are often employed for loading multiple drugs due to their versatility and controlled release of these drugs in response to a tumor specific ...
Hao Cai, Yufan Xiang, Yu-Jun Zeng, Zhiqian Li, Xiu-Li Zheng, Qiang Luo, Hong-Yan Zhu, Qi-Yong Gong, Z. Gu, Yan-Hong Liu, Hu Zhang, Kui Luo   +11 more
semanticscholar   +1 more source