Results 11 to 20 of about 25,778,187 (334)
The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara +2 more
doaj +3 more sources
Cathepsin B gene disruption induced Leishmania donovani proteome remodeling implies cathepsin B role in secretome regulation. [PDF]
PLoS ONE, 2013 Leishmania cysteine proteases are potential vaccine candidates and drug targets. To study the role of cathepsin B cysteine protease, we have generated and characterized cathepsin B null mutant L. donovani parasites. L.
Teklu Kuru Gerbaba, Lashitew Gedamu
doaj +2 more sources
Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndrome
European Respiratory Journal, 2020 Bronchiolitis obliterans syndrome (BOS) is a major complication after lung transplantation (LTx). BOS is characterised by massive peribronchial fibrosis, leading to air trapping-induced pulmonary dysfunction.
C. Morrone +9 more
semanticscholar +2 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CTSB (cathepsin B), with data on DNA, on the protein encoded, and where the gene is implicated.
Jevnikar, Z, Kos, J
openaire +4 more sources
Exploring the Association between Cathepsin B and Parkinson’s Disease [PDF]
Brain SciencesObjective: The aim of this study is to investigate the association between Cathepsin B and Parkinson’s Disease (PD), with a particular focus on determining the role of N-acetylaspartate as a potential mediator.
Changhao Lu +9 more
doaj +2 more sources
Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways
Cell Death and Disease, 2023 Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal and lysosomal compartments. It is involved in the turnover of intracellular and extracellular proteins.
Zhen Xie +10 more
semanticscholar +1 more source
Smart Delivery Systems Responsive to Cathepsin B Activity for Cancer Treatment
Pharmaceutics, 2023 Cathepsin B is a lysosomal cysteine protease, contributing to vital cellular homeostatic processes including protein turnover, macroautophagy of damaged organelles, antigen presentation, and in the extracellular space, it takes part in tissue remodeling,
V. S. Egorova +5 more
semanticscholar +1 more source
Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B
Biochemistry, 2022 CA-074 is a selective inhibitor of cathepsin B, a lysosomal cysteine protease. CA-074 has been utilized in numerous studies to demonstrate the role of this protease in cellular and physiological functions. Cathepsin B in numerous human disease mechanisms
Michael C. Yoon +6 more
semanticscholar +1 more source
Applied Sciences, 2021 Cathepsin B is an endo-lysosomal cysteine protease. However, its increased expression and altered localization to the extracellular space, to mitochondria, or to the nucleus has been linked to tumor progression.
Tripti Tamhane +7 more
doaj +1 more source
ACS Chemical Biology, 2021 Cathepsin B is a cysteine protease that normally functions within acidic lysosomes for protein degradation, but in numerous human diseases, cathepsin B translocates to the cytosol having neutral pH where the enzyme activates inflammation and cell death ...
Michael C. Yoon +12 more
semanticscholar +1 more source