Results 11 to 20 of about 122,992 (302)
Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells [PDF]
Cell Reports, 2017 Summary: Triple-negative breast cancer (TNBC) is considered incurable with currently available treatments, highlighting the need for therapeutic targets and predictive biomarkers.
Kyung-Min Yang +14 more
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Cathepsin B in human peripheral blood lymphocytes as a peripheral biomarker for cardiac hypertrophy [PDF]
Scientific ReportsPrevious studies have demonstrated that cathepsin B is up-regulated in the myocardium of both mice and humans with pathological cardiac hypertrophy. However, it remains unknown whether cathepsin B is detectable in human peripheral blood lymphocytes (PBLs)
Dandan Feng +8 more
doaj +2 more sources
Cathepsin B: Multiple roles in cancer [PDF]
PROTEOMICS – Clinical Applications, 2014 Proteases, including intracellular proteases, play roles at many different stages of malignant progression. Our focus here is cathepsin B, a lysosomal cysteine cathepsin. High levels of cathepsin B are found in a wide variety of human cancers, levels that often induce secretion and association of cathepsin B with the tumor cell membrane.
Neha, Aggarwal, Bonnie F, Sloane
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Cathepsin B as a cancer target [PDF]
Expert Opinion on Therapeutic Targets, 2013 Cathepsin B is of significant importance to cancer therapy as it is involved in various pathologies and oncogenic processes in humans. Numerous studies have shown that abnormal regulation of cathepsin B overexpression is correlated with invasive and metastatic phenotypes in cancers.
Christopher S, Gondi, Jasti S, Rao
openaire +4 more sources
Exploring the Association between Cathepsin B and Parkinson’s Disease [PDF]
Brain SciencesObjective: The aim of this study is to investigate the association between Cathepsin B and Parkinson’s Disease (PD), with a particular focus on determining the role of N-acetylaspartate as a potential mediator.
Changhao Lu +9 more
doaj +2 more sources
Plant cathepsin B, a versatile protease. [PDF]
Front Plant SciPlant proteases are essential enzymes that play key roles during crucial phases of plant life. Some proteases are mainly involved in general protein turnover and recycle amino acids for protein synthesis. Other proteases are involved in cell signalling, cleave specific substrates and are key players during important genetically controlled molecular ...
Coppola M, Mach L, Gallois P.
europepmc +4 more sources
The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara +2 more
doaj +1 more source
Applied Sciences, 2021 Cathepsin B is an endo-lysosomal cysteine protease. However, its increased expression and altered localization to the extracellular space, to mitochondria, or to the nucleus has been linked to tumor progression.
Tripti Tamhane +7 more
doaj +1 more source
Molecules, 2023 Background: Cathepsin K, which is involved in bone resorption, is a good target for treating osteoporosis, but no clinically approved medicine has been developed.
Shun Sato +6 more
doaj +1 more source
Applied Sciences, 2022 The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk−/−) mice have learning and memory impairments.
Denise M. T. Yu +6 more
doaj +1 more source