Results 51 to 60 of about 25,778,187 (334)
Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging
Neural Regeneration Research, 2019 Interleukin-1β is a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer’s disease, Parkinson’s disease, stroke and persistent pain.
H. Nakanishi
semanticscholar +1 more source
Peptide synthesis by recombinant Fasciola hepatica cathepsin L1 [PDF]
, 2006 Synthesis of the tripeptide Z-Phe-Arg-SerNH2 has been accomplished by a recombinant cysteine protease, cathepsin L1 from liver fluke (Fasciola hepatica), using Z-Phe-Arg-OMe as acyl acceptor and SerNH2 as nucleophile in 0.1 M ammonium acetate pH 9.0–12.5%
Ruth, Deborah M. +2 more
core +1 more source
Cloning of a cDNA encoding Schistosoma mansoni cathepsin C and expression in the yeast Pichia pastoris [PDF]
, 2003 The cDNA encoding the proenzyme of cathepsin C from the parasitic helminth Schistosoma mansoni was amplified from a cDNA library using 5’ and 3’ specific primers containing sites for SnaBI and Avrll digestion.
Carty, Charlene
core +2 more sources
Gastroenterology, 2017 BACKGROUND & AIMS: Acute pancreatitis is characterized by premature intracellular activation of digestive proteases within pancreatic acini and a consecutive systemic inflammatory response.
M. Sendler +12 more
semanticscholar +1 more source
Parasites & Vectors, 2019 Background Three main enzymes including cathepsin B, cathepsin D and acid phosphatase are involved in vitellin degradation, which is a major biochemical event of the embryonic development and can provide nutrients and metabolites for tick embryos. In the
Tian-Tian Zhang +6 more
doaj +1 more source
Cathepsin B: Active site mapping with peptidic substrates and inhibitors.
Bioorganic & Medicinal Chemistry, 2019 The potential of papain-like cysteine proteases, such as cathepsin B, as drug discovery targets for systemic human diseases has prevailed over the past years.
Janina Schmitz +5 more
semanticscholar +1 more source
Cathepsin B Is Implicated in Triglyceride (TG)-Induced Cell Death of Macrophage
Korean Journal of Clinical Laboratory Science, 2020 Macrophage cell death contributes to the formation of plaque, leading to the development of atherosclerosis. The accumulation of triglyceride (TG) is also associated with the pathogenesis of atherosclerosis.
Byung Chul Jung +3 more
doaj +1 more source
Expression of Cathepsins B, D, and G in Isocitrate Dehydrogenase-Wildtype Glioblastoma
Frontiers in Surgery, 2017 AimTo investigate the expression of cathepsins B, D, and G, in relation to the cancer stem cell (CSC) subpopulations, we have previously characterized within isocitrate dehydogenase (IDH)-wildtype glioblastoma (IDHWGB).Methods3,3-Diaminobezidine (DAB ...
Sabrina P. Koh +7 more
doaj +1 more source
Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies [PDF]
Biological Chemistry, 2014 Abstract Cathepsin B has been demonstrated to be involved in several proteolytic processes that support tumor progression and metastasis and neurodegeneration. To further clarify its role, defined monoclonal antibodies are needed.
Weber, Ekkehard +7 more
openaire +3 more sources
Expression of Cathepsins B, D, and G in WHO Grade I Meningioma
Frontiers in Surgery, 2019 Aim: We have recently demonstrated the presence of putative tumor stem cells (TSCs) in World Health Organization (WHO) grade I meningioma (MG) localized to the microvessels, which expresses components of the renin-angiotensin system (RAS).
Rosanna M. A. Rahman +12 more
doaj +1 more source