New Insights into the Role of Cysteine Cathepsins in Neuroinflammation [PDF]
Biomolecules, 2021 Neuroinflammation, which is mediated by microglia and astrocytes, is associated with the progression of neurodegenerative diseases. Increasing evidence shows that activated microglia induce the expression and secretion of various lysosomal cathepsins ...
Anja Pišlar +2 more
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The Interplay of Glycosaminoglycans and Cysteine Cathepsins in Mucopolysaccharidosis [PDF]
Biomedicines, 2023 Mucopolysaccharidosis (MPS) consists of a group of inherited lysosomal storage disorders that are caused by a defect of certain enzymes that participate in the metabolism of glycosaminoglycans (GAGs).
Alexis David +4 more
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Cysteine Cathepsins and Their Extracellular Roles: Shaping the Microenvironment [PDF]
Cells, 2019 For a long time, cysteine cathepsins were considered primarily as proteases crucial for nonspecific bulk proteolysis in the endolysosomal system. However, this view has dramatically changed, and cathepsins are now considered key players in many important
Eva Vidak +3 more
doaj +7 more sources
Cysteine Cathepsins in Tumor-Associated Immune Cells [PDF]
Frontiers in Immunology, 2019 Cysteine cathepsins are key regulators of the innate and adaptive arms of the immune system. Their expression, activity, and subcellular localization are associated with the distinct development and differentiation stages of immune cells.
Tanja Jakoš +4 more
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Cysteine Cathepsins as Therapeutic Targets in Immune Regulation and Immune Disorders [PDF]
Biomedicines, 2023 Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital role in several processes—such as protein degradation, changes in cell signaling, cell morphology, migration and proliferation, and energy metabolism. In addition to
Emanuela Senjor +2 more
exaly +4 more sources
Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells [PDF]
Frontiers in Immunology, 2014 Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. Some, such as cathepsins B, L and H are expressed constitutively in most immune cells.
Janko eKos +3 more
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Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins [PDF]
Communications Biology, 2023 Addressing the elusive specificity of cysteine cathepsins, which in contrast to caspases and trypsin-like proteases lack strict specificity determining P1 pocket, calls for innovative approaches. Proteomic analysis of cell lysates with human cathepsins K,
Livija Tušar +16 more
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The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance [PDF]
International Journal of Molecular Sciences, 2019 Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance.
Magdalena Rudzinska +2 more
exaly +6 more sources
Redundancy between Cysteine Cathepsins in Murine Experimental Autoimmune Encephalomyelitis. [PDF]
PLoS ONE, 2015 The cysteine cathepsins B, S, and L are functionally linked to antigen processing, and hence to autoimmune disorders such as multiple sclerosis. Stemming from several studies that demonstrate that mice can be protected from experimental autoimmune ...
Euan Ramsay Orr Allan +1 more
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Cysteine Cathepsins and Matrix Metalloproteases Among Breast Cancer Patients [PDF]
Breast Cancer: Targets and Therapy, 2021 Solomon Tsegaye,1 Mohammed Mehdi,2 Wajana L Labisso,3 Daniel Seifu Melka2 1Department of Biochemistry, College of Health Sciences, Assela University, Addis Ababa, Ethiopia; 2Department of Biochemistry, College of Health Sciences, Addis Ababa University ...
Tsegaye S, Mehdi M, Lako WL, Melka DS
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