Results 11 to 20 of about 120,191 (200)
Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants. [PDF]
Int J Mol Sci, 2020 International audienceBesides their primary involvement in the recycling and degradation of proteins in endo-lysosomal compartments and also in specialized biological functions, cysteine cathepsins are pivotal proteolytic contributors of various ...
Lalmanach G +5 more
europepmc +7 more sources
Cysteine Cathepsins in Human Carious Dentin [PDF]
Journal of Dental Research, 2011 Matrix metalloproteinases (MMPs) are important in dentinal caries, and analysis of recent data demonstrates the presence of other collagen-degrading enzymes, cysteine cathepsins, in human dentin.
Tjaderhane, L. +19 more
core +3 more sources
Cysteine Cathepsins Inhibition Affects Their Expression and Human Renal Cancer Cell Phenotype [PDF]
Cancers, 2020 Renal cancer would greatly benefit from new therapeutic strategies since, in advanced stages, it is refractory to classical chemotherapeutic approaches. In this context, lysosomal protease cysteine cathepsins may represent new pharmacological targets. In
Yu M Efremov +2 more
exaly +3 more sources
In silico analysis of cysteine cathepsins identified from the transcriptome profile of blunt snout bream (Megalobrama amblycephala) [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2018 Cysteine cathepsins are described as lysosomal proteases with housekeeping and highly specialised functions in many organisms. In this study, cysteine cathepsins were identified from the transcriptome profile of blunt snout bream (Megalobrama ...
Ngoc Tuan Tran, Wei-Min Wang
doaj +3 more sources
Cysteine cathepsins are a fascinating group of proteolytic enzymes that play diverse and crucial roles in numerous biological processes, both in health and disease.
Ercegovič Rot, Ana +4 more
core +2 more sources
Human cysteine cathepsins are not reliable markers of infection by Pseudomonas aeruginosa in cystic fibrosis. [PDF]
PLoS ONE, 2011 Cysteine cathepsins have emerged as new players in inflammatory lung disorders. Their activities are dramatically increased in the sputum of cystic fibrosis (CF) patients, suggesting that they are involved in the pathophysiology of CF.
Clément Naudin +9 more
doaj +2 more sources
Cysteine Cathepsins in Human Dentin-Pulp Complex
Journal of Endodontics, 2010 Introduction: Collagen-degrading matrix metalloproteinases (MMPs) are expressed by odontoblasts and present in dentin. We hypothesized that odontoblasts express other collagen-degrading enzymes such as cysteine cathepsins, and their activity would be ...
NASCIMENTO, Fabio D. +10 more
core +3 more sources
Inflammatory Regulation of Cysteine Cathepsins [PDF]
, 2008 Cysteine cathepsins B, L and S are endosomal/lysosomal proteases that participate in numerous physiological systems. Cathepsin expression and activity are altered during various inflammatory diseases, including rheumatoid arthritis, atherosclerosis ...
Creasy, Blaine
core +2 more sources
Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins [PDF]
Neoplasia: An International Journal for Oncology Research, 2013 One of the noncellular microenvironmental factors that contribute to malignancy of solid tumors is acidic peritumoral pH. We have previously demonstrated that extracellular acidosis leads to localization of the cysteine pro-tease cathepsin B on the tumor
Jennifer M Rothberg +10 more
doaj +2 more sources
Cysteine Cathepsins in Breast Cancer: Promising Targets for Fluorescence-Guided Surgery. [PDF]
Mol Imaging Biol, 2023 The majority of breast cancer patients is treated with breast-conserving surgery (BCS) combined with adjuvant radiation therapy. Up to 40% of patients has a tumor-positive resection margin after BCS, which necessitates re-resection or additional boost ...
Linders DGJ +12 more
europepmc +2 more sources