Cysteine Cathepsins and Matrix Metalloproteases Among Breast Cancer Patients [PDF]
Breast Cancer: Targets and Therapy, 2021 Solomon Tsegaye,1 Mohammed Mehdi,2 Wajana L Labisso,3 Daniel Seifu Melka2 1Department of Biochemistry, College of Health Sciences, Assela University, Addis Ababa, Ethiopia; 2Department of Biochemistry, College of Health Sciences, Addis Ababa University ...
Tsegaye S, Mehdi M, Lako WL, Melka DS
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Molecular probes for selective detection of cysteine cathepsins. [PDF]
Org Biomol Chem, 2021 One of these is not like the others: the 11 cysteine cathepsins have overlapping but distinct roles in pathology, and molecular probes enable their cumulative or selective detection in many applications.
Schleyer KA, Cui L.
europepmc +3 more sources
Cysteine cathepsins in human carious dentin. [PDF]
J Dent Res, 2011 Matrix metalloproteinases (MMPs) are important in dentinal caries, and analysis of recent data demonstrates the presence of other collagen-degrading enzymes, cysteine cathepsins, in human dentin. This study aimed to examine the presence, source, and activity of cysteine cathepsins in human caries. Cathepsin B was detected with immunostaining.
Nascimento FD +9 more
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Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation. [PDF]
Cell Death Dis, 2016 Sirtuin-1 (SIRT1) regulates hepatic metabolism but its contribution to NF-κB-dependent inflammation has been overlooked. Cysteine cathepsins (Cathepsin B or S, CTSB/S) execute specific functions in physiological processes, such as protein degradation ...
de Mingo Á +8 more
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Probing the activity of cysteine cathepsins in inflammatory bowel diseases [PDF]
Scientific ReportsCathepsin S is a cysteine protease that has been implicated in inflammatory bowel diseases (IBD) for its ability to promote visceral pain. Given its pro-inflammatory roles, we hypothesized that cathepsin S would drive other symptoms associated with IBD ...
Bethany M. Anderson +13 more
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Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins
Neoplasia: An International Journal for Oncology Research, 2013 One of the noncellular microenvironmental factors that contribute to malignancy of solid tumors is acidic peritumoral pH. We have previously demonstrated that extracellular acidosis leads to localization of the cysteine pro-tease cathepsin B on the tumor
Jennifer M Rothberg +10 more
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Computational predictions of cysteine cathepsin‐mediated fibrinogen proteolysis [PDF]
Protein Science, 2017 AbstractFibrin clot formation is a proteolytic cascade of events with thrombin and plasmin identified as the main proteases cleaving fibrinogen precursor, and the fibrin polymer, respectively. Other proteases may be involved directly in fibrin(ogen) cleavage, clot formation, and resolution, or in the degradation of fibrin‐based scaffolds emerging as ...
Meghan C. Ferrall‐Fairbanks +4 more
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Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model. [PDF]
EJNMMI Res, 2020 Suurs FV +9 more
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Shaping the Immune Response: Cathepsins in Virus-Dendritic Cell Interactions [PDF]
CellsDendritic cells (DCs) are among the first immune cells to detect viral invasion and play a central role in initiating and shaping antiviral immune responses.
Adrianna Niedzielska +5 more
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