Biomolecular Concepts, 2011 Cystatins are small proteins, typically composed of 100–120 amino acids, which together with similar proteins devoid of inhibitory properties, belong to a cystatin ‘superfamily’.
Esposito Veronica, Temussi Piero A.
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Cystatins from the Human Liver Fluke Opisthorchis viverrini: Molecular Characterization and Functional Analysis [PDF]
Pathogens, 2023 A high incidence of cholangiocarcinoma (bile duct cancer) has been observed in Thailand. This usually rare cancer has been associated with infection with the human liver fluke, Opisthorchis viverrini.
Amornrat Geadkaew-Krenc +6 more
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Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes [PDF]
Parasites & Vectors, 2015 Background Transmission of pathogens by ticks is greatly supported by tick saliva released during feeding. Dendritic cells (DC) act as immunological sentinels and interconnect the innate and adaptive immune system. They control polarization of the immune
Jaroslava Lieskovská +6 more
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Proteolytic Activity Inhibition in Gingival Fluid by Cysteine Protease Inhibitors Obtained from Egg White and Fallopia japonica Extract: An In Vitro Study [PDF]
BiomedicinesBackground/Objectives: Gingipains produced by P. gingivalis have been shown to be directly related to periodontal tissue degradation and are significant molecular targets in therapy of periodontitis.
Maciej Siewiński +12 more
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Frontiers in Cellular and Infection Microbiology, 2017 The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host.
Jindřich Chmelař +2 more
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The Acari Hypothesis, V: deciphering allergenicity [PDF]
Frontiers in AllergyThe Acari Hypothesis posits that acarians, i.e., mites and ticks, are operative agents of allergy. It derived from observations that allergens are molecular elements of acarians or acarian foodstuffs.
Andrew C. Retzinger +1 more
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Recombinant cystatin ingestion by Diaphorina citri reduces insect survival: insights into the HLB host–bacteria interaction (D. citri–CLas) focused on DcCathL studies [PDF]
Frontiers in Insect ScienceHuanglongbing (HLB) is considered the most serious Citrus disease for which there are currently no effective control methods. The putative agents of HLB, Candidatus Liberibacter asiaticus (CLas), and the vector Diaphorina citri, are widespread in citrus ...
Sâmara V. Rocha +13 more
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Cystatins: unravelling the biological implications for neuroprotection [PDF]
Archives of Medical Science, 2023 Cystatins, a family of proteins known for their inhibitory role against cysteine proteases, have garnered significant attention in the field of neurodegeneration. Numerous genetic, experimental, and clinical studies concerning cystatin C suggest it plays
Bartłomiej Stańczykiewicz +3 more
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Host-Directed Therapies Based on Protease Inhibitors to Control Mycobacterium tuberculosis and HIV Coinfection [PDF]
MicroorganismsDespite continuous and extensive global efforts in the fight against tuberculosis (TB), this infectious disease continues to exert a tremendous burden on public health concerns and deaths worldwide.
Manoj Mandal +3 more
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Innate Immune Response in Brain, NF-Kappa B Signaling and Cystatins
Frontiers in Molecular Neuroscience, 2015 Recently several reports have demonstrated that innate immune response and inflammation have an important role in major neurodegenerative diseases.
Nataša Kopitar-Jerala
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