Biomolecular Concepts, 2011 Cystatins are small proteins, typically composed of 100–120 amino acids, which together with similar proteins devoid of inhibitory properties, belong to a cystatin ‘superfamily’.
Veronica Esposito, Piero Andrea Temussi
exaly +5 more sources
Cystatins from the Human Liver Fluke Opisthorchis viverrini: Molecular Characterization and Functional Analysis [PDF]
Pathogens, 2023 A high incidence of cholangiocarcinoma (bile duct cancer) has been observed in Thailand. This usually rare cancer has been associated with infection with the human liver fluke, Opisthorchis viverrini.
Amornrat Geadkaew-Krenc +6 more
doaj +3 more sources
Cystatins in Immune System [PDF]
Journal of Cancer, 2013 Cystatins comprise a large superfamily of related proteins with diverse biological activities. They were initially characterised as inhibitors of lysosomal cysteine proteases, however, in recent years some alternative functions for cystatins have been ...
Špela Magister, Janko Kos
doaj +4 more sources
Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host.
Jindrich Chmelař +2 more
exaly +4 more sources
Evolution of C, D and S-type cystatins in mammals: an extensive gene duplication in primates.
PLoS ONE, 2014 Cystatins are a family of inhibitors of cysteine peptidases that comprises the salivary cystatins (D and S-type cystatins) and cystatin C. These cystatins are encoded by a multigene family (CST3, CST5, CST4, CST1 and CST2) organized in tandem in the ...
Patrícia de Sousa-Pereira +5 more
doaj +2 more sources
Proteolytic Activity Inhibition in Gingival Fluid by Cysteine Protease Inhibitors Obtained from Egg White and Fallopia japonica Extract: An In Vitro Study [PDF]
BiomedicinesBackground/Objectives: Gingipains produced by P. gingivalis have been shown to be directly related to periodontal tissue degradation and are significant molecular targets in therapy of periodontitis.
Maciej Siewiński +12 more
doaj +2 more sources
Evolutionary Analysis of Cystatins of Early-Emerging Metazoans Reveals a Novel Subtype in Parasitic Cnidarians [PDF]
Biology, 2021 The evolutionary aspects of cystatins are greatly underexplored in early-emerging metazoans. Thus, we surveyed the gene organization, protein architecture, and phylogeny of cystatin homologues mined from 110 genomes and the transcriptomes of 58 basal ...
Pavla Bartošová-Sojková +10 more
doaj +2 more sources
Physical exercise stimulates salivary secretion of cystatins.
PLoS ONE, 2019 Physical exercise is known to activate the sympathetic nervous system, which influences the production of saliva from salivary glands. Our examination of saliva collected from highly trained athletes before and after a number of physical competititions ...
Marcelo de Lima Sant'Anna +6 more
doaj +2 more sources
Parasites & Vectors, 2015 Background Cystatins are a group of cysteine protease inhibitors responsible for physiological proteolysis regulation and present in a wide range of organisms. Studies about this class of inhibitors in parasites have contributed to clarify their roles in
Luís Fernando Parizi +8 more
doaj +2 more sources
Recombinant cystatin ingestion by Diaphorina citri reduces insect survival: insights into the HLB host–bacteria interaction (D. citri–CLas) focused on DcCathL studies [PDF]
Frontiers in Insect ScienceHuanglongbing (HLB) is considered the most serious Citrus disease for which there are currently no effective control methods. The putative agents of HLB, Candidatus Liberibacter asiaticus (CLas), and the vector Diaphorina citri, are widespread in citrus ...
Sâmara V. Rocha +13 more
doaj +2 more sources