Results 1 to 10 of about 3,702 (189)
Biomolecular Concepts, 2011 Cystatins are small proteins, typically composed of 100–120 amino acids, which together with similar proteins devoid of inhibitory properties, belong to a cystatin ‘superfamily’.
Piero Temussi, Veronica Esposito
exaly +5 more sources
Pathogens, 2023 A high incidence of cholangiocarcinoma (bile duct cancer) has been observed in Thailand. This usually rare cancer has been associated with infection with the human liver fluke, Opisthorchis viverrini.
Amornrat Geadkaew-Krenc +6 more
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Evolution of C, D and S-type cystatins in mammals: an extensive gene duplication in primates.
PLoS ONE, 2014 Cystatins are a family of inhibitors of cysteine peptidases that comprises the salivary cystatins (D and S-type cystatins) and cystatin C. These cystatins are encoded by a multigene family (CST3, CST5, CST4, CST1 and CST2) organized in tandem in the ...
Patrícia de Sousa-Pereira +5 more
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Biology, 2021 The evolutionary aspects of cystatins are greatly underexplored in early-emerging metazoans. Thus, we surveyed the gene organization, protein architecture, and phylogeny of cystatin homologues mined from 110 genomes and the transcriptomes of 58 basal ...
Pavla Bartošová-Sojková +10 more
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Comparative analysis of cystatin superfamily in platyhelminths. [PDF]
PLoS ONE, 2015 The cystatin superfamily is comprised of cysteine proteinase inhibitors and encompasses at least 3 subfamilies: stefins, cystatins and kininogens. In this study, the platyhelminth cystatin superfamily was identified and grouped into stefin and cystatin ...
Aijiang Guo
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Frontiers in Immunology, 2021 The moment a very old bacterial pathogen met a young virus from the 80’s defined the beginning of a tragic syndemic for humanity. Such is the case for the causative agent of tuberculosis and the human immunodeficiency virus (HIV).
Elsa Anes +2 more
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Frontiers in Immunology, 2021 Tuberculosis owes its resurgence as a major global health threat mostly to the emergence of drug resistance and coinfection with HIV. The synergy between HIV and Mycobacterium tuberculosis (Mtb) modifies the host immune environment to enhance both viral ...
David Pires +9 more
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Frontiers in Neuroscience, 2021 Alzheimer disease (AD) is the most prevalent neurodegenerative disease in the elderly, characterized by accumulation in the brain of misfolded proteins, inflammation, and oxidative damage leading to neuronal cell death.
Cristina Contini +14 more
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Structural Dynamics Investigation of Human Family 1 & 2 Cystatin-Cathepsin L1 Interaction: A Comparison of Binding Modes. [PDF]
PLoS ONE, 2016 Cystatin superfamily is a large group of evolutionarily related proteins involved in numerous physiological activities through their inhibitory activity towards cysteine proteases. Despite sharing the same cystatin fold, and inhibiting cysteine proteases
Suman Kumar Nandy, Alpana Seal
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Evolutionary Analysis of the Cystatin Family in Three Schistosoma Species
Frontiers in Genetics, 2014 The cystatin family comprises cysteine protease inhibitors distributed in 3 subfamilies (I25A-C). Family members lacking cystatin activity are currently unclassified. Little is known about the evolution of Schistosoma cystatins, their physiological roles,
Yesid eCuesta-Astroz +4 more
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