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Host-Directed Therapies for Tuberculosis [PDF]
Pathogens, 2022 Tuberculosis (TB) is one of the leading causes of death worldwide, consistently threatening public health. Conventional tuberculosis treatment requires a long-term treatment regimen and is associated with side effects.
Eui-Kwon Jeong, Hyo-Ji Lee, Yu-Jin Jung
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Host-Directed Therapies for Cutaneous Leishmaniasis [PDF]
Frontiers in Immunology, 2021 Cutaneous leishmaniasis exhibits a wide spectrum of clinical presentations from self-resolving infections to severe chronic disease. Anti-parasitic drugs are often ineffective in the most severe forms of the disease, and in some cases the magnitude of ...
Fernanda O. Novais +2 more
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Host directed therapies: COVID-19 and beyond [PDF]
Current Research in Pharmacology and Drug Discovery, 2021 The global spread of SARS-CoV-2 has necessitated the development of novel, safe and effective therapeutic agents against this virus to stop the pandemic, however the development of novel antivirals may take years, hence, the best alternative available ...
Devavrat Tripathi +3 more
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Host Directed Therapies for Tuberculous Meningitis [version 2; peer review: 2 approved] [PDF]
Wellcome Open Research, 2021 A dysregulated host immune response significantly contributes to morbidity and mortality in tuberculous meningitis (TBM). Effective host directed therapies (HDTs) are critical to improve survival and clinical outcomes.
Nathan C Bahr +12 more
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Host-Directed Therapies: Modulating Inflammation to Treat Tuberculosis [PDF]
Frontiers in Immunology, 2021 Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), most human hosts are able to contain the infection and avoid progression to active TB disease through expression of a balanced, homeostatic immune response ...
Stefanie Krug +2 more
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Special Issue: From Host–Pathogen Interaction to Host-Directed Therapies [PDF]
Microorganisms, 2021 Despite the enormous progress made in the last few decades, infectious diseases still represent a huge challenge to human society and health systems, as evidenced by the recent SARS-CoV-2 pandemic [...]
Maria Salomé Gomes, Luisa Pereira
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Recent Advances in Host-Directed Therapies for Tuberculosis and Malaria [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, and malaria, caused by parasites from the Plasmodium genus, are two of the major causes of death due to infectious diseases in the world.
Kely C. Matteucci +5 more
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Host-directed therapies in pulmonary tuberculosis: Updates on anti-inflammatory drugs [PDF]
Frontiers in Medicine, 2022 Tuberculosis (TB) is a lethal disease and remains one of the top ten causes of mortality by an infectious disease worldwide. It can also result in significant morbidity related to persistent inflammation and tissue damage.
Juan M. Cubillos-Angulo +30 more
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The New Frontier of Host-Directed Therapies for Mycobacterium avium Complex [PDF]
Frontiers in Immunology, 2021 Mycobacterium avium complex (MAC) is an increasingly important cause of morbidity and mortality, and is responsible for pulmonary infection in patients with underlying lung disease and disseminated disease in patients with AIDS.
Nathan P. Crilly +3 more
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Host-Pathogen Interaction as a Novel Target for Host-Directed Therapies in Tuberculosis [PDF]
Frontiers in Immunology, 2020 Tuberculosis (TB) has been a transmittable human disease for many thousands of years, and M. tuberculosis is again the number one cause of death worldwide due to a single infectious agent.
Rodrigo Abreu, Pramod Giri, Fred Quinn
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