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Host-Directed Therapies for Tuberculosis [PDF]
, 2020 TB is considered as one of the oldest documented infectious diseases in the world and is believed to be the leading cause of mortality due to a single infectious agent.
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Host-Pathogen Interaction as a Novel Target for Host-Directed Therapies in Tuberculosis [PDF]
Frontiers in Immunology, 2020 Tuberculosis (TB) has been a transmittable human disease for many thousands of years, and M. tuberculosis is again the number one cause of death worldwide due to a single infectious agent.
Rodrigo Abreu, Pramod Giri, Fred Quinn
doaj +2 more sources
Targeting Molecular Inflammatory Pathways in Granuloma as Host-Directed Therapies for Tuberculosis [PDF]
Frontiers in Immunology, 2021 Globally, more than 10 million people developed active tuberculosis (TB), with 1.4 million deaths in 2020. In addition, the emergence of drug-resistant strains in many regions of the world threatens national TB control programs.
Reto Guler +17 more
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Host-directed therapies for tuberculosis: quantitative systems pharmacology approaches
Trends in Pharmacological Sciences, 2021 Host-directed therapies (HDTs) that modulate host-pathogen interactions offer an innovative strategy to combat Mycobacterium tuberculosis (Mtb) infections.
Ottenhoff, T.H.M. +5 more
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Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria [PDF]
Scientific ReportsThe emergence of antimicrobial resistance has created an urgent need for alternative treatments against bacterial pathogens. Here, we investigated kinase inhibitors as potential host-directed therapies (HDTs) against intracellular bacteria, specifically ...
Robin H. G. A. van den Biggelaar +9 more
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Host-directed therapies targeting the tuberculosis granuloma stroma.
Pathogens and Disease, 2021 Mycobacteria have co-evolved with their hosts resulting in pathogens adept at intracellular survival. Pathogenic mycobacteria actively manipulate infected macrophages to drive granuloma formation while subverting host cell processes to create a ...
Hortle, E, Oehlers, SH
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Host-directed therapy for tuberculosis
European Journal of Medical ResearchCurrent TB treatment regimens are hindered by drug resistance, numerous adverse effects, and long treatment durations, highlighting the need for ‘me-better’ treatment regimens. Host-directed therapy (HDT) has gained recognition as a promising approach in
Qi Li +6 more
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Host-Directed Drug Therapies for Neglected Tropical Diseases Caused by Protozoan Parasites [PDF]
Frontiers in Microbiology, 2018 The neglected tropical diseases (NTDs) caused by protozoan parasites are responsible for significant morbidity and mortality worldwide. Current treatments using anti-parasitic drugs are toxic and prolonged with poor patient compliance.
Sanjay Varikuti +9 more
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International Journal for Parasitology: Drugs and Drug Resistance, 2019 Visceral leishmaniasis (VL) is associated with treatment complications due to the continued growth of resistant parasites toward currently available pathogen-directed therapeutics.
M. Shamim Hasan Zahid +6 more
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Host-Directed Antiviral Therapy [PDF]
Clinical Microbiology Reviews, 2020 Antiviral drugs have traditionally been developed by directly targeting essential viral components. However, this strategy often fails due to the rapid generation of drug-resistant viruses. Recent genome-wide approaches, such as those employing small interfering RNA (siRNA) or clustered regularly interspaced short palindromic repeats (CRISPR) or those ...
Naveen Kumar +6 more
openaire +2 more sources