Results 21 to 30 of about 2,511,362 (213)

Autophagy in tuberculosis: advances, translational gaps, and the promise of host-directed therapies [PDF]

Frontiers in Cellular and Infection Microbiology
Tuberculosis (TB) is still a major global health threat, worsened by the advancement of multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis (Mtb).
Manjunath Challa, Jessy Padma B, Sivakumar Shanmugam   +2 more
doaj   +2 more sources

Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria [PDF]

Scientific Reports
The emergence of antimicrobial resistance has created an urgent need for alternative treatments against bacterial pathogens. Here, we investigated kinase inhibitors as potential host-directed therapies (HDTs) against intracellular bacteria, specifically ...
Robin H. G. A. van den Biggelaar, Kimberley V. Walburg, Susan J. F. van den Eeden, Cassandra L. R. van Doorn, Eugenia Meiler, Alex S. de Ries, M. Chiara Fusco, Annemarie H. Meijer, Tom H. M. Ottenhoff, Anno Saris   +9 more
doaj   +2 more sources

Host-directed therapies for tackling multi-drug resistant tuberculosis : learning from the pasteur-bechamp debates [PDF]

, 2015
Tuberculosis remains a global emergency causing an estimated 1.5 million deaths annually. For several decades the major focus of tuberculosis treatment has been on antibiotic development targeting Mycobacterium tuberculosis.
Abdulla, S, Cardona, P-J, Grobusch, MP, Mboko, L, Gant, V, Mayosi, B, Zumla, A, Mandansein, R, Reither, K, Mwaba, P, Nyirenda, T, Garcia-Basteiro, AL, Bates, M, Ippolito, G, Munderi, P, Singh, N, Schito, M, Dieye, TN, Diarra, B, Kaleebu, P, Aseffa, A, Tientcheu, L, Corrah, T, Mulenga, M, Parida, S, Kaufmann, SHE, Macete, E, Noursadeghi, M, Petersen, E, Vilaplana, C, Rakotosamimanana, N, Yeboah-Manu, D, Rustomjee, R, Wejse, C, Martinson, N, Elkington, P, McHugh, TD, Oliver, M, Russell, JBW, Host-Directed Therapies Network Consortium,, Wallis, RS, Sanne, I, Chakaya, J, Bonnet, M, Antonio, M, Padayatchi, N, Sheikh, A, Maeurer, Markus, Host-Directed Therapies Network (HDT-NET) Consortium, ., Rasolofo, V, Kibiki, G, Zumla, A., Maeurer, M, Churchyard, G, Maiga, A, Aklillu, E, Ramjee, G, Mfinanga, E, Hoelscher, M, Steyn, AJC, Ntoumi, F, Edwards, S, Kapata, N, Gagneux, S, Menendez, C, Zumla, Alimuddin, Maeurer, M., Craig, G, Mfinanga, S, Wilkinson, RJ   +69 more
core   +8 more sources

Editorial: Innovative host-directed therapies for combatting antimicrobial resistance (AMR) [PDF]

Frontiers in Cellular and Infection Microbiology
Mariola J. Ferraro, Mariola J. Ferraro, Daniel M. Czyz, Daniel M. Czyz   +3 more
doaj   +2 more sources

Improving treatment outcomes for MDR-TB — Novel host-directed therapies and personalised medicine of the future

International Journal of Infectious Diseases, 2019
Multidrug-resistant TB (MDR-TB) is a major threat to global health security. In 2017, only 50% of patients with MDR-TB who received WHO-recommended treatment were cured.
Martin Rao, Giuseppe Ippolito, Sayoki Mfinanga, Francine Ntoumi, Dorothy Yeboah-Manu, Cris Vilaplana, Alimuddin Zumla, Markus Maeurer   +7 more
doaj   +3 more sources

Host-Directed Drug Therapies for Neglected Tropical Diseases Caused by Protozoan Parasites [PDF]

Frontiers in Microbiology, 2018
The neglected tropical diseases (NTDs) caused by protozoan parasites are responsible for significant morbidity and mortality worldwide. Current treatments using anti-parasitic drugs are toxic and prolonged with poor patient compliance.
Sanjay Varikuti, Bijay Kumar Jha, Greta Volpedo, Greta Volpedo, Nathan M. Ryan, Gregory Halsey, Omar M. Hamza, Bradford S. McGwire, Abhay R. Satoskar, Abhay R. Satoskar   +9 more
doaj   +2 more sources

Host-directed therapies for infectious diseases: current status, recent progress, and future prospects. [PDF]

Lancet Infect Dis, 2016
Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage.
Zumla A, Rao M, Wallis RS, Kaufmann SH, Rustomjee R, Mwaba P, Vilaplana C, Yeboah-Manu D, Chakaya J, Ippolito G, Azhar E, Hoelscher M, Maeurer M, Host-Directed Therapies Network consortium.   +13 more
europepmc   +2 more sources

Adjunctive host-directed therapies for pulmonary tuberculosis: a prospective, open-label, phase 2, randomised controlled trial.

Lancet Respir Med, 2021
Wallis RS, Ginindza S, Beattie T, Arjun N, Likoti M, Edward VA, Rassool M, Ahmed K, Fielding K, Ahidjo BA, Vangu MDT, Churchyard G.   +11 more
europepmc   +2 more sources

Host Immune-Metabolic Adaptations Upon Mycobacterial Infections and Associated Co-Morbidities

Frontiers in Immunology, 2021
Mycobacterial diseases are a major public health challenge. Their causative agents include, in order of impact, members of the Mycobacterium tuberculosis complex (causing tuberculosis), Mycobacterium leprae (causing leprosy), and non-tuberculous ...
Alba Llibre, Martin Dedicoat, Julie G. Burel, Caroline Demangel, Matthew K. O’Shea, Matthew K. O’Shea, Claudio Mauro   +6 more
doaj   +1 more source

Lactate Metabolism and Signaling in Tuberculosis and Cancer: A Comparative Review

Frontiers in Cellular and Infection Microbiology, 2021
Infection with Mycobacterium tuberculosis (Mtb) leading to tuberculosis (TB) disease continues to be a major global health challenge. Critical barriers, including but not limited to the development of multi-drug resistance, lack of diagnostic assays that
Dilara Kiran, Randall J. Basaraba
doaj   +1 more source