Results 31 to 40 of about 103,777 (248)

Host-directed therapies for infectious diseases: current status, recent progress, and future prospects. [PDF]

Lancet Infect Dis, 2016
Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage.
Zumla A, Rao M, Wallis RS, Kaufmann SH, Rustomjee R, Mwaba P, Vilaplana C, Yeboah-Manu D, Chakaya J, Ippolito G, Azhar E, Hoelscher M, Maeurer M, Host-Directed Therapies Network consortium.   +13 more
europepmc   +2 more sources

Host‐directed therapy to combat mycobacterial infections* [PDF]

Immunological Reviews, 2021
AbstractUpon infection, mycobacteria, such asMycobacterium tuberculosis(Mtb) and nontuberculous mycobacteria (NTM), are recognized by host innate immune cells, triggering a series of intracellular processes that promote mycobacterial killing. Mycobacteria, however, have developed multiple counter‐strategies to persist and survive inside host cells.
Kilinç, Gül, Saris, Anno, Ottenhoff, Tom H. M., Haks, Mariëlle C.   +3 more
openaire   +3 more sources

Adjunctive host-directed therapies for pulmonary tuberculosis: a prospective, open-label, phase 2, randomised controlled trial

Lancet Respiratory Medicine,the, 2021
Robert S Wallis, Trevor Beattie, Vinodh A Edward   +2 more
exaly   +2 more sources

Host-directed therapies for tackling multi-drug resistant tuberculosis : learning from the pasteur-bechamp debates

, 2015
Tuberculosis remains a global emergency causing an estimated 1.5 million deaths annually. For several decades the major focus of tuberculosis treatment has been on antibiotic development targeting Mycobacterium tuberculosis.
Abdulla, S, Cardona, P-J, Grobusch, MP, Mboko, L, Gant, V, Mayosi, B, Zumla, A, Mandansein, R, Reither, K, Mwaba, P, Nyirenda, T, Garcia-Basteiro, AL, Bates, M, Ippolito, G, Munderi, P, Singh, N, Schito, M, Dieye, TN, Diarra, B, Kaleebu, P, Aseffa, A, Tientcheu, L, Corrah, T, Mulenga, M, Parida, S, Kaufmann, SHE, Macete, E, Noursadeghi, M, Petersen, E, Vilaplana, C, Rakotosamimanana, N, Yeboah-Manu, D, Rustomjee, R, Wejse, C, Martinson, N, Elkington, P, McHugh, TD, Oliver, M, Russell, JBW, Host-Directed Therapies Network Consortium,, Wallis, RS, Sanne, I, Chakaya, J, Bonnet, M, Antonio, M, Padayatchi, N, Sheikh, A, Maeurer, Markus, Host-Directed Therapies Network (HDT-NET) Consortium, ., Rasolofo, V, Kibiki, G, Zumla, A., Maeurer, M, Churchyard, G, Maiga, A, Aklillu, E, Ramjee, G, Mfinanga, E, Hoelscher, M, Steyn, AJC, Ntoumi, F, Edwards, S, Kapata, N, Gagneux, S, Menendez, C, Zumla, Alimuddin, Maeurer, M., Craig, G, Mfinanga, S, Wilkinson, RJ   +69 more
core   +4 more sources

Inflammation and tuberculosis: host‐directed therapies [PDF]

Journal of Internal Medicine, 2014
AbstractTuberculosis (TB) is an airborne infectious disease that kills almost two million individuals every year. Multidrug‐resistant (MDR) TB is caused by strains of Mycobacterium tuberculosis (M. tb) resistant to isoniazid and rifampin, the backbone of first‐line antitubercular treatment.
A, Zumla, M, Rao, S K, Parida, S, Keshavjee, G, Cassell, R, Wallis, R, Axelsson-Robertsson, M, Doherty, J, Andersson, M, Maeurer   +9 more
openaire   +2 more sources

Host Immune-Metabolic Adaptations Upon Mycobacterial Infections and Associated Co-Morbidities

Frontiers in Immunology, 2021
Mycobacterial diseases are a major public health challenge. Their causative agents include, in order of impact, members of the Mycobacterium tuberculosis complex (causing tuberculosis), Mycobacterium leprae (causing leprosy), and non-tuberculous ...
Alba Llibre, Martin Dedicoat, Julie G. Burel, Caroline Demangel, Matthew K. O’Shea, Matthew K. O’Shea, Claudio Mauro   +6 more
doaj   +1 more source

Host-Directed Therapies Based on Protease Inhibitors to Control <i>Mycobacterium tuberculosis</i> and HIV Coinfection. [PDF]

Microorganisms
Despite continuous and extensive global efforts in the fight against tuberculosis (TB), this infectious disease continues to exert a tremendous burden on public health concerns and deaths worldwide.
Mandal M, Pires D, Azevedo-Pereira JM, Anes E.   +3 more
europepmc   +2 more sources

Lactate Metabolism and Signaling in Tuberculosis and Cancer: A Comparative Review

Frontiers in Cellular and Infection Microbiology, 2021
Infection with Mycobacterium tuberculosis (Mtb) leading to tuberculosis (TB) disease continues to be a major global health challenge. Critical barriers, including but not limited to the development of multi-drug resistance, lack of diagnostic assays that
Dilara Kiran, Randall J. Basaraba
doaj   +1 more source

A Review and Meta-Analysis of Influenza Interactome Studies

Frontiers in Microbiology, 2022
Annually, the influenza virus causes 500,000 deaths worldwide. Influenza-associated mortality and morbidity is especially high among the elderly, children, and patients with chronic diseases.
Sonja Courtney Jun Hui Chua, Sonja Courtney Jun Hui Chua, Sonja Courtney Jun Hui Chua, Sonja Courtney Jun Hui Chua, Jianzhou Cui, Jianzhou Cui, Jianzhou Cui, David Engelberg, David Engelberg, David Engelberg, Lina Hsiu Kim Lim, Lina Hsiu Kim Lim, Lina Hsiu Kim Lim   +12 more
doaj   +1 more source

Editorial: Exploiting Novel Combined Host- and Pathogen-Directed Therapies for Combating Bacterial Multidrug Resistance [PDF]

, 2020
Editorial on the Research Topic "Exploiting Novel Combined Host- and Pathogen-Directed Therapies for Combating Bacterial Multidrug ...
Rossolini GM, Oggioni MR, Fraziano M, Nisini R   +3 more
core   +1 more source