Results 31 to 40 of about 2,511,362 (213)

Host-Directed Therapies for Tuberculosis [PDF]

, 2020
TB is considered as one of the oldest documented infectious diseases in the world and is believed to be the leading cause of mortality due to a single infectious agent.

core   +2 more sources

A Review and Meta-Analysis of Influenza Interactome Studies

Frontiers in Microbiology, 2022
Annually, the influenza virus causes 500,000 deaths worldwide. Influenza-associated mortality and morbidity is especially high among the elderly, children, and patients with chronic diseases.
Sonja Courtney Jun Hui Chua, Sonja Courtney Jun Hui Chua, Sonja Courtney Jun Hui Chua, Sonja Courtney Jun Hui Chua, Jianzhou Cui, Jianzhou Cui, Jianzhou Cui, David Engelberg, David Engelberg, David Engelberg, Lina Hsiu Kim Lim, Lina Hsiu Kim Lim, Lina Hsiu Kim Lim   +12 more
doaj   +1 more source

Self-Directed Learning [PDF]

, 2021
This book on self-directed learning (SDL) is devoted to original academic scholarship within the field of education, and is the 6th volume in the North-West University (NWU) SDL book series. In this book the authors explore how self-directed learning can
Mzuza, Maureen K., Bailey, Roxanne, du Toit-Brits, Charlene, Sebotsa, Tswakae, Kriek, Jeanne, Olivier, Jako, Fleisher, Steven C., Mahlaba, Sfiso C., Wirth, Karl R., Bergamin, Per, Dhakulkar, Amit, Nuhfer, Edward B., Dudu, Washington T., Jagals, Divan, Sebatana, Motlhale J., Watson, Rachel, Chahine, Iman C., Blignaut, Henry, de Beer, Josef   +18 more
core   +1 more source

Host-directed therapies for tuberculosis: quantitative systems pharmacology approaches [PDF]

, 2021
Host-directed therapies (HDTs) that modulate host-pathogen interactions offer an innovative strategy to combat Mycobacterium tuberculosis (Mtb) infections.
Ottenhoff, T.H.M., Mehta, K.M., Mehta, K., Graaf, P.H. van der, Spaink, H.P., Hasselt, J.G.C. van   +5 more
core   +1 more source

Sildenafil, a Type-5 Phosphodiesterase Inhibitor, Fails to Reverse Myeloid-Derived Suppressor Cell-Mediated T Cell Suppression in Cells Isolated From Tuberculosis Patients

Frontiers in Immunology, 2022
Successful TB treatment is hampered by increasing resistance to the two most effective first-line anti-TB drugs, namely isoniazid and rifampicin, thus innovative therapies focused on host processes, termed host-directed therapies (HDTs), are promising ...
Vinzeigh N. Leukes, Stephanus T. Malherbe, Andriette Hiemstra, Leigh A. Kotze, Kelly Roos, Alana Keyser, Dalene De Swardt, Andrea Gutschmidt, Gerhard Walzl, Nelita du Plessis   +9 more
doaj   +1 more source

Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune Modulation

Antibiotics, 2020
Tuberculosis (TB) is one of the leading causes of mortality and morbidity, particularly in developing countries, presenting a major threat to the public health. The currently recommended long term treatment regimen with multiple antibiotics is associated
Sultan Ahmed, Rubhana Raqib, Guðmundur Hrafn Guðmundsson, Peter Bergman, Birgitta Agerberth, Rokeya Sultana Rekha   +5 more
doaj   +1 more source

Host directed therapies for tuberculous meningitis

, 2022
A dysregulated host immune response significantly contributes to morbidity and mortality in tuberculous meningitis (TBM). Effective host directed therapies (HDTs) are critical to improve survival and clinical outcomes.
Marise Bremer (10172756), Nguyen Thuy Thuong Thuong (9214604), Johan Schoeman (4424989), Tuberculous Meningitis International Research Consortium (8550132), Robert J Wilkinson (8128959), Nathan C Bahr (9552347), Fiona V Cresswell (8856179), Guy E Thwaites (8550129), Rachel PJ Lai (8281866), David R Boulware (8856176), Joseph Donovan (9214571), Angharad G Davis (8604333), Ariba Dadabhoy (10172759), Ronald Van Toorn (8281863)   +13 more
core   +1 more source

Antituberculosis Therapy and Gut Microbiota: Review of Potential Host Microbiota Directed-Therapies

Frontiers in Cellular and Infection Microbiology, 2021
Tuberculosis (TB) remains a major public health concern with millions of deaths every year. The overlap with HIV infections, long treatment duration, and the emergence of drug resistance are significant obstacles to the control of the disease.
Dramane Diallo, Anou M. Somboro, Anou M. Somboro, Seydou Diabate, Bacar Baya, Amadou Kone, Yeya S. Sarro, Bourahima Kone, Bassirou Diarra, Souleymane Diallo, Mahamadou Diakite, Seydou Doumbia, Yacouba Toloba, Robert L. Murphy, Mamoudou Maiga, Mamoudou Maiga   +15 more
doaj   +1 more source

Editorial: Exploiting Novel Combined Host- and Pathogen-Directed Therapies for Combating Bacterial Multidrug Resistance [PDF]

, 2020
Editorial on the Research Topic "Exploiting Novel Combined Host- and Pathogen-Directed Therapies for Combating Bacterial Multidrug ...
Rossolini GM, Oggioni MR, Fraziano M, Nisini R   +3 more
core   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source