Results 31 to 40 of about 78,528 (234)

Doxycycline host-directed therapy in human pulmonary tuberculosis [PDF]

Journal of Clinical Investigation, 2021
BACKGROUNDMatrix metalloproteinases (MMPs) are key regulators of tissue destruction in tuberculosis (TB) and may be targets for host-directed therapy. We conducted a phase II double-blind, randomized, controlled trial investigating doxycycline, a licensed broad-spectrum MMP inhibitor, in patients with pulmonary TB.METHODSThirty patients with pulmonary ...
Qing Hao Miow, Andres F. Vallejo, Yu Wang, Jia Mei Hong, Chen Bai, Felicia S.W. Teo, Alvin D.Y. Wang, Hong Rong Loh, Tuan Zea Tan, Ying Ding, Hoi Wah She, Suay Hong Gan, Nicholas I. Paton, Josephine Lum, Alicia Tay, Cynthia B.E. Chee, Paul A. Tambyah, Marta E. Polak, Yee Tang Wang, Amit Singhal, Paul T. Elkington, Jon S. Friedland, Catherine W.M. Ong   +22 more
openaire   +4 more sources

Potentials of Host-Directed Therapies in Tuberculosis Management. [PDF]

J Clin Med, 2019
Tuberculosis (TB) remains as a leading cause of mortality in developing countries, persisting as a major threat to the global public health. Current treatment involving a long antibiotic regimen brings concern to the topic of patient compliance, contributing to the emergence of drug resistant TB.
Dara Y, Volcani D, Shah K, Shin K, Venketaraman V.   +4 more
europepmc   +4 more sources

Host-directed therapies for bacterial and viral infections. [PDF]

Nat Rev Drug Discov, 2018
Despite the recent increase in the development of antivirals and antibiotics, antimicrobial resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and additional alternative approaches to treat infectious diseases are urgently needed. Host-directed therapy (HDT) is an emerging approach in the field of anti-infectives.
Kaufmann SHE, Dorhoi A, Hotchkiss RS, Bartenschlager R.   +3 more
europepmc   +5 more sources

Host-directed therapies for tuberculosis: quantitative systems pharmacology approaches

Trends in Pharmacological Sciences, 2022
Host-directed therapies (HDTs) that modulate host-pathogen interactions offer an innovative strategy to combat Mycobacterium tuberculosis (Mtb) infections. When combined with tuberculosis (TB) antibiotics, HDTs could contribute to improving treatment outcomes, reducing treatment duration, and preventing resistance development.
Mehta, K.M., Spaink, H.P., Ottenhoff, T.H.M., Graaf, P.H. van der, Hasselt, J.G.C. van   +4 more
openaire   +4 more sources

Host-Directed Therapy in Tuberculosis: Targeting Host Metabolism [PDF]

Frontiers in Immunology, 2020
Mycobacterium tuberculosis (Mtb) has complex and intricate interactions with host immune cells. Mtb can survive, persist, and grow within macrophages and thereby circumvent detection by the innate immune system. Recently, the field of immunometabolism, which focuses on the link between metabolism and immune function, has provided us with an improved ...
Jae-Sung Kim, Jae-Sung Kim, Ye-Ram Kim, Ye-Ram Kim, Chul-Su Yang, Chul-Su Yang   +5 more
openaire   +4 more sources

Repurposing Antifungals for Host-Directed Antiviral Therapy? [PDF]

Pharmaceuticals, 2022
Because of their epidemic and pandemic potential, emerging viruses are a major threat to global healthcare systems. While vaccination is in general a straightforward approach to prevent viral infections, immunization can also cause escape mutants that hide from immune cell and antibody detection.
Sebastian Schloer, Jonas Goretzko, Ursula Rescher   +2 more
openaire   +3 more sources

Sildenafil, a Type-5 Phosphodiesterase Inhibitor, Fails to Reverse Myeloid-Derived Suppressor Cell-Mediated T Cell Suppression in Cells Isolated From Tuberculosis Patients

Frontiers in Immunology, 2022
Successful TB treatment is hampered by increasing resistance to the two most effective first-line anti-TB drugs, namely isoniazid and rifampicin, thus innovative therapies focused on host processes, termed host-directed therapies (HDTs), are promising ...
Vinzeigh N. Leukes, Stephanus T. Malherbe, Andriette Hiemstra, Leigh A. Kotze, Kelly Roos, Alana Keyser, Dalene De Swardt, Andrea Gutschmidt, Gerhard Walzl, Nelita du Plessis   +9 more
doaj   +1 more source

Morphoproteomic-Guided Host-Directed Therapy for Tuberculosis [PDF]

Frontiers in Immunology, 2017
In an effort to develop more effective therapy for tuberculosis (TB), research efforts are looking toward host-directed therapy, reprograming the body's natural defenses to better control the infection. While significant progress is being made, the efforts are limited by lack of understanding of the pathology and pathogenesis of adult type TB disease ...
Brown, Robert E., Hunter, Robert L., Hwang, Shen-An   +2 more
openaire   +2 more sources

Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune Modulation

Antibiotics, 2020
Tuberculosis (TB) is one of the leading causes of mortality and morbidity, particularly in developing countries, presenting a major threat to the public health. The currently recommended long term treatment regimen with multiple antibiotics is associated
Sultan Ahmed, Rubhana Raqib, Guðmundur Hrafn Guðmundsson, Peter Bergman, Birgitta Agerberth, Rokeya Sultana Rekha   +5 more
doaj   +1 more source

Host-directed therapies for infectious diseases: current status, recent progress, and future prospects. [PDF]

Lancet Infect Dis, 2016
Zumla A, Rao M, Wallis RS, Kaufmann SH, Rustomjee R, Mwaba P, Vilaplana C, Yeboah-Manu D, Chakaya J, Ippolito G, Azhar E, Hoelscher M, Maeurer M, Host-Directed Therapies Network consortium.   +13 more
europepmc   +2 more sources