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, 2023 Tuberculosis is one of the deadliest infectious diseases in the world. It is exacerbated by the rise of multi-drug resistant strains. Host-directed therapies are an innovative approach by targeting host pathways to enhance immunity and suppress bacterial
Larsson, Simon
core +1 more source
Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Tuberculosis (TB) was responsible for more deaths in 2019 than any other infectious agent. This epidemic is exacerbated by the ongoing development of multi-drug resistance and HIV co-infection. Recent studies have therefore focused on identifying host-directed therapies (HDTs) that can be used in combination with anti-mycobacterial drugs to shorten the
Bridgette M. Cumming +4 more
openaire +3 more sources
Frontiers in Immunology, 2021 Tuberculosis owes its resurgence as a major global health threat mostly to the emergence of drug resistance and coinfection with HIV. The synergy between HIV and Mycobacterium tuberculosis (Mtb) modifies the host immune environment to enhance both viral ...
David Pires +9 more
doaj +1 more source
The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
wiley +1 more source
Host-Directed Therapy in Tuberculosis: Targeting Host Metabolism [PDF]
Frontiers in Immunology, 2020 Mycobacterium tuberculosis (Mtb) has complex and intricate interactions with host immune cells. Mtb can survive, persist, and grow within macrophages and thereby circumvent detection by the innate immune system. Recently, the field of immunometabolism, which focuses on the link between metabolism and immune function, has provided us with an improved ...
Jae-Sung Kim +5 more
openaire +4 more sources
Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection
eLife, 2019 Mycobacterium tuberculosis is the leading worldwide cause of death due to a single infectious agent. Existing anti-tuberculous therapies require long treatments and are complicated by multi-drug-resistant strains.
Molly A Matty +7 more
doaj +1 more source
The Multifaceted Role of Annexin A1 in Viral Infections
Cells, 2023 Dysregulated inflammatory responses are often correlated with disease severity during viral infections. Annexin A1 (AnxA1) is an endogenous pro-resolving protein that timely regulates inflammation by activating signaling pathways that culminate with the ...
Filipe Resende +4 more
doaj +1 more source
In vitro models of human granuloma formation to analyze host-directed therapies
, 2020 Contributed to book by PC Karakousis, R Hafner, ML Gennaro (editors) (2021), in Advances in Host-Directed Therapies Against ...
Tezera, Liku Bekele +6 more
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Microorganisms, 2023 Tuberculosis (TB) treatment relies primarily on 70-year-old drugs, and prophylaxis suffers from the lack of an effective vaccine. Among the 10 million people exhibiting disease symptoms yearly, 450,000 have multidrug or extensively drug-resistant (MDR or
Manoj Mandal +4 more
doaj +1 more source