Results 41 to 50 of about 103,777 (248)

Host-directed therapies for bacterial and viral infections. [PDF]

Nat Rev Drug Discov, 2018
Despite the recent increase in the development of antivirals and antibiotics, antimicrobial resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and additional alternative approaches to treat infectious diseases are urgently needed. Host-directed therapy (HDT) is an emerging approach in the field of anti-infectives.
Kaufmann SHE, Dorhoi A, Hotchkiss RS, Bartenschlager R.   +3 more
europepmc   +5 more sources

Host directed therapies for tuberculous meningitis

, 2022
A dysregulated host immune response significantly contributes to morbidity and mortality in tuberculous meningitis (TBM). Effective host directed therapies (HDTs) are critical to improve survival and clinical outcomes.
Marise Bremer (10172756), Nguyen Thuy Thuong Thuong (9214604), Johan Schoeman (4424989), Tuberculous Meningitis International Research Consortium (8550132), Robert J Wilkinson (8128959), Nathan C Bahr (9552347), Fiona V Cresswell (8856179), Guy E Thwaites (8550129), Rachel PJ Lai (8281866), David R Boulware (8856176), Joseph Donovan (9214571), Angharad G Davis (8604333), Ariba Dadabhoy (10172759), Ronald Van Toorn (8281863)   +13 more
core   +1 more source

Sildenafil, a Type-5 Phosphodiesterase Inhibitor, Fails to Reverse Myeloid-Derived Suppressor Cell-Mediated T Cell Suppression in Cells Isolated From Tuberculosis Patients

Frontiers in Immunology, 2022
Successful TB treatment is hampered by increasing resistance to the two most effective first-line anti-TB drugs, namely isoniazid and rifampicin, thus innovative therapies focused on host processes, termed host-directed therapies (HDTs), are promising ...
Vinzeigh N. Leukes, Stephanus T. Malherbe, Andriette Hiemstra, Leigh A. Kotze, Kelly Roos, Alana Keyser, Dalene De Swardt, Andrea Gutschmidt, Gerhard Walzl, Nelita du Plessis   +9 more
doaj   +1 more source

Effects of host‐directed therapies on the pathology of tuberculosis [PDF]

The Journal of Pathology, 2020
AbstractMycobacterium tuberculosis, the causative agent of tuberculosis (TB), has co‐evolved with the human immune system and utilizes multiple strategies to persist within infected cells, to hijack several immune mechanisms, and to cause severe pathology and tissue damage in the host.
Liana Tsenova, Amit Singhal
openaire   +2 more sources

Morphoproteomic-Guided Host-Directed Therapy for Tuberculosis [PDF]

Frontiers in Immunology, 2017
In an effort to develop more effective therapy for tuberculosis (TB), research efforts are looking toward host-directed therapy, reprograming the body's natural defenses to better control the infection. While significant progress is being made, the efforts are limited by lack of understanding of the pathology and pathogenesis of adult type TB disease ...
Brown, Robert E., Hunter, Robert L., Hwang, Shen-An   +2 more
openaire   +2 more sources

Targeting immunometabolism in host-directed therapies to fungal disease [PDF]

Clinical and Experimental Immunology, 2021
Summary Fungal infections affect over a billion people and are responsible for more than 1.5 million deaths each year. Despite progress in diagnostic and therapeutic approaches, the management of severe fungal infections remains a challenge.
Gonçalves, Samuel M, Ferreira, Anaísa V, Cunha, Cristina, Carvalho, Agostinho   +3 more
openaire   +2 more sources

Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune Modulation

Antibiotics, 2020
Tuberculosis (TB) is one of the leading causes of mortality and morbidity, particularly in developing countries, presenting a major threat to the public health. The currently recommended long term treatment regimen with multiple antibiotics is associated
Sultan Ahmed, Rubhana Raqib, Guðmundur Hrafn Guðmundsson, Peter Bergman, Birgitta Agerberth, Rokeya Sultana Rekha   +5 more
doaj   +1 more source

Host-directed kinase inhibitors act as novel therapies against novel therapies against intracellular Staphylococcus aureus [PDF]

, 2019
Host-directed therapeutics are a promising anti-infective strategy against intracellular bacterial pathogens. Repurposing host-targeted drugs approved by the FDA in the US, the MHRA in the UK and/or regulatory equivalents in other countries, is ...
Calle-Patino, Yolanda, Mateos, Luis M, Letek, Michal, Cooper, Frederic, Behrends, Volker, Stölting, Helen, Behrends, Volker; id_orcid, Calle, Yolanda, Letek Polberg, Michal, Majstorovic, Andrea, Mateos, Luis M., Ihle, Nadine, Bileckaja, Narina, Bravo-Santano, Natalia   +13 more
core   +3 more sources

Antituberculosis Therapy and Gut Microbiota: Review of Potential Host Microbiota Directed-Therapies

Frontiers in Cellular and Infection Microbiology, 2021
Tuberculosis (TB) remains a major public health concern with millions of deaths every year. The overlap with HIV infections, long treatment duration, and the emergence of drug resistance are significant obstacles to the control of the disease.
Dramane Diallo, Anou M. Somboro, Anou M. Somboro, Seydou Diabate, Bacar Baya, Amadou Kone, Yeya S. Sarro, Bourahima Kone, Bassirou Diarra, Souleymane Diallo, Mahamadou Diakite, Seydou Doumbia, Yacouba Toloba, Robert L. Murphy, Mamoudou Maiga, Mamoudou Maiga   +15 more
doaj   +1 more source

Immunometabolism and Pulmonary Infections: Implications for Protective Immune Responses and Host-Directed Therapies. [PDF]

Front Microbiol, 2019
The biology and clinical efficacy of immune cells from patients with infectious diseases or cancer are associated with metabolic programming. Host immune- and stromal-cell genetic and epigenetic signatures in response to the invading pathogen shape ...
Rao M, Dodoo E, Zumla A, Maeurer M.
europepmc   +2 more sources