Results 41 to 50 of about 78,528 (234)

Antituberculosis Therapy and Gut Microbiota: Review of Potential Host Microbiota Directed-Therapies

Frontiers in Cellular and Infection Microbiology, 2021
Tuberculosis (TB) remains a major public health concern with millions of deaths every year. The overlap with HIV infections, long treatment duration, and the emergence of drug resistance are significant obstacles to the control of the disease.
Dramane Diallo, Anou M. Somboro, Anou M. Somboro, Seydou Diabate, Bacar Baya, Amadou Kone, Yeya S. Sarro, Bourahima Kone, Bassirou Diarra, Souleymane Diallo, Mahamadou Diakite, Seydou Doumbia, Yacouba Toloba, Robert L. Murphy, Mamoudou Maiga, Mamoudou Maiga   +15 more
doaj   +1 more source

Host-directed therapy for tuberculosis

European Journal of Medical Research
Current TB treatment regimens are hindered by drug resistance, numerous adverse effects, and long treatment durations, highlighting the need for 'me-better' treatment regimens. Host-directed therapy (HDT) has gained recognition as a promising approach in TB treatment. It allows the repurposing of existing drugs approved for other conditions and aims to
Na Tian, Hongqian Chu, Qi Li, Hong Sun, Jingfang Zhang, Naihui Chu, Zhaogang Sun   +6 more
openaire   +3 more sources

Modulation of Cystatin C in Human Macrophages Improves Anti-Mycobacterial Immune Responses to Mycobacterium tuberculosis Infection and Coinfection With HIV

Frontiers in Immunology, 2021
Tuberculosis owes its resurgence as a major global health threat mostly to the emergence of drug resistance and coinfection with HIV. The synergy between HIV and Mycobacterium tuberculosis (Mtb) modifies the host immune environment to enhance both viral ...
David Pires, Marta Calado, Tomás Velez, Manoj Mandal, Maria João Catalão, Olivier Neyrolles, Geanncarlo Lugo-Villarino, Christel Vérollet, José Miguel Azevedo-Pereira, Elsa Anes   +9 more
doaj   +1 more source

Host-Directed Therapies for Tuberculosis. [PDF]

Cold Spring Harb Perspect Med, 2015
Tobin DM.
europepmc   +3 more sources

The Multifaceted Role of Annexin A1 in Viral Infections

Cells, 2023
Dysregulated inflammatory responses are often correlated with disease severity during viral infections. Annexin A1 (AnxA1) is an endogenous pro-resolving protein that timely regulates inflammation by activating signaling pathways that culminate with the ...
Filipe Resende, Simone de Araújo, Luciana Pádua Tavares, Mauro Martins Teixeira, Vivian Vasconcelos Costa   +4 more
doaj   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection

eLife, 2019
Mycobacterium tuberculosis is the leading worldwide cause of death due to a single infectious agent. Existing anti-tuberculous therapies require long treatments and are complicated by multi-drug-resistant strains.
Molly A Matty, Daphne R Knudsen, Eric M Walton, Rebecca W Beerman, Mark R Cronan, Charlie J Pyle, Rafael E Hernandez, David M Tobin   +7 more
doaj   +1 more source

Modulation of Cystatin F in Human Macrophages Impacts Cathepsin-Driven Killing of Multidrug-Resistant Mycobacterium tuberculosis

Microorganisms, 2023
Tuberculosis (TB) treatment relies primarily on 70-year-old drugs, and prophylaxis suffers from the lack of an effective vaccine. Among the 10 million people exhibiting disease symptoms yearly, 450,000 have multidrug or extensively drug-resistant (MDR or
Manoj Mandal, David Pires, Maria João Catalão, José Miguel Azevedo-Pereira, Elsa Anes   +4 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source