Results 1 to 10 of about 125,364 (304)

Different PPD-stimulated cytokine responses from patients infected with genetically distinct Mycobacterium tuberculosis complex lineages

International Journal of Infectious Diseases, 2021
Objectives: The genetic diversity of Mycobacterium tuberculosis complex (MTBC) influences the immune response of the host, which may affect the immunodiagnostic tests and biomarker assessment studies used for tuberculosis (TB).
Paulo Ranaivomanana, Marie Sylvianne Rabodoarivelo, Mame Diarra Bousso Ndiaye, Niaina Rakotosamimanana, Voahangy Rasolofo   +4 more
doaj   +1 more source

From 3D to 2D: Harmonization of Protocols for Two-dimensional Cultures on Cell Culture Inserts of Intestinal Organoids from Various Species

Bio-Protocol, 2022
In the expanding field of intestinal organoid research, various protocols for three- and two-dimensional organoid-derived cell cultures exist. Two-dimensional organoid-derived monolayers are used to overcome some limitations of three-dimensional organoid
David Warschkau, Estefania Delgado-Betancourt, David Holthaus, Antonia Müller, Gudrun Kliem, Susanne Krug, Joerg- Schulzke, Toni Aebischer, Christian Klotz, Frank Seeber   +9 more
doaj   +1 more source

Sporulation in mycobacteria [PDF]

Proceedings of the National Academy of Sciences, 2009
Mycobacteria owe their success as pathogens to their ability to persist for long periods within host cells in asymptomatic, latent forms before they opportunistically switch to the virulent state. The molecular mechanisms underlying the transition into dormancy and emergence from it are not clear. Here we show that old cultures of
Jaydip, Ghosh, Pontus, Larsson, Bhupender, Singh, B M Fredrik, Pettersson, Nurul M, Islam, Sailendra Nath, Sarkar, Santanu, Dasgupta, Leif A, Kirsebom   +7 more
openaire   +2 more sources

Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea

BMC Infectious Diseases, 2022
Background Molecular mechanisms determining the transmission and prevalence of drug resistant tuberculosis (DR-TB) in Papua New Guinea (PNG) are poorly understood. We used genomic and drug susceptibility data to explore the evolutionary history, temporal
Arnold Bainomugisa, Evelyn Lavu, Sushil Pandey, Suman Majumdar, Jennifer Banamu, Chris Coulter, Ben Marais, Lachlan Coin, Stephen M. Graham, Philipp du Cros   +9 more
doaj   +1 more source

Urine lipoarabinomannan in HIV uninfected, smear negative, symptomatic TB patients: effective sample pretreatment for a sensitive immunoassay and mass spectrometry

Scientific Reports, 2021
Our study sought to determine whether urine lipoarabinomannan (LAM) could be validated in a sample cohort that consisted mainly of HIV uninfected individuals that presented with tuberculosis symptoms.
Anita G. Amin, Prithwiraj De, Barbara Graham, Roger I. Calderon, Molly F. Franke, Delphi Chatterjee   +5 more
doaj   +1 more source

Unique Features of Mycobacterium abscessus Biofilms Formed in Synthetic Cystic Fibrosis Medium

Frontiers in Microbiology, 2021
Characterizing Mycobacterium abscessus complex (MABSC) biofilms under host-relevant conditions is essential to the design of informed therapeutic strategies targeted to this persistent, drug-tolerant, population of extracellular bacilli.
Juan M. Belardinelli, Wei Li, Charlotte Avanzi, Shiva K. Angala, Elena Lian, Crystal J. Wiersma, Zuzana Palčeková, Kevin H. Martin, Bhanupriya Angala, Vinicius C. N. de Moura, Callan Kerns, Victoria Jones, Mercedes Gonzalez-Juarrero, Rebecca M. Davidson, Jerry A. Nick, Jerry A. Nick, Bradley R. Borlee, Mary Jackson   +17 more
doaj   +1 more source

Physiology of Mycobacteria [PDF]

, 2009
Mycobacterium tuberculosis is a prototrophic, metabolically flexible bacterium that has achieved a spread in the human population that is unmatched by any other bacterial pathogen. The success of M. tuberculosis as a pathogen can be attributed to its extraordinary stealth and capacity to adapt to environmental changes throughout the course of infection.
Cook, Gregory M., Berney, Michael, Gebhard, Susanne, Heinemann, Matthias, Cox, Robert A., Danilchanka, Olga, Niederweis, Michael   +6 more
openaire   +4 more sources

Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway

BMC Infectious Diseases, 2021
Background The aim of the current study was to improve our understanding of the origins and transmission of Mycobacterium africanum (MAF) in Norway. Methods Whole-genome sequences (WGS) were generated for all (n = 29) available clinical isolates received
Vegard Eldholm, Janne O. Rønning, Anne Torunn Mengshoel, Trude Arnesen   +3 more
doaj   +1 more source

Phenotypic Diversity of Cryptococcus neoformans var. neoformans Clinical Isolates from Localized and Disseminated Infections

Microorganisms, 2022
Cryptococcus neoformans var. neoformans is the second most prevalent agent of cryptococcosis in central Europe. Infections mostly present with localized skin and disseminated infections.
Zena M. Birkenfeld, Nikita Dittel, Thomas Harrer, Christoph Stephan, Albrecht F. Kiderlen, Volker Rickerts   +5 more
doaj   +1 more source

Successful expansion of Mycobacterium tuberculosis Latin American and Mediterranean sublineage (L4.3/LAM) in Tunisia mainly driven by a single, long-established clonal complex

International Journal of Infectious Diseases, 2021
Objectives: To explore the evolutionary history of Mycobacterium tuberculosis Latin American and Mediterranean (L4.3/LAM) sublineage in Tunisia, where it predominates.
Mohamed Amine Skhairia, Naira Dekhil, Besma Mhenni, Saloua Ben Fradj, Helmi Mardassi   +4 more
doaj   +1 more source