Results 21 to 30 of about 94,343 (260)

Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria [PDF]

, 2007
Background. Mycolic acids are a complex mixture of branched, long-chain fatty acids, representing key components of the highly hydrophobic mycobacterial cell wall.
Robert C Reynolds, Coxon, Geoffrey D., Dover, Lynn, Geoffrey D Coxon, Besra, Gurdyal; id_orcid, Besra, Gurdyal S., Besra, Gurdyal, Dover, Lynn G., Reynolds, Robert C., Laurent Kremer, Trivelli, X, Trivelli, Xavier, James C Sacchettini, Sacchettini, JC, Anuradha Alahari, Lynn G Dover, Kremer, Laurent, Kremer, L, Guérardel, Yann, Dover, Lynn G, Coxon, Geoffrey D, Coxon, GD, Gurdyal S Besra, Sacchettini, James C., Reynolds, Robert, Yann Guérardel, Reynolds, Robert C, Reynolds, RC, Coxon, Geoffrey, Alahari, Anuradha, Sacchettini, James C, Gu rardel, Y, Alahari, A, Besra, Gurdyal S, Xavier Trivelli, El-Shemy, Hany, Sacchettini, James   +36 more
core   +1 more source

Real-Time PCR for Molecular Detection of Zoonotic and Non-Zoonotic Giardia spp. in Wild Rodents

Microorganisms, 2021
Giardiasis in humans is a gastrointestinal disease transmitted by the potentially zoonotic Giardia duodenalis genotypes (assemblages) A and B. Small wild rodents such as mice and voles are discussed as potential reservoirs for G.
Christian Klotz, Elke Radam, Sebastian Rausch, Petra Gosten-Heinrich, Toni Aebischer   +4 more
doaj   +1 more source

Trying to See the Forest through the Trees: Deciphering the Nature of Memory Immunity to Mycobacterium tuberculosis

Frontiers in Immunology, 2018
The purpose of vaccination against tuberculosis and other diseases is to establish a heightened state of acquired specific resistance in which the memory immune response is capable of mediating an accelerated and magnified expression of protection to the
Ian M. Orme, Marcela I. Henao-Tamayo
doaj   +1 more source

Proline Dehydrogenase and Pyrroline 5 Carboxylate Dehydrogenase from Mycobacterium tuberculosis: Evidence for Substrate Channeling

Pathogens, 2023
In Mycobacterium tuberculosis, proline dehydrogenase (PruB) and ∆1-pyrroline-5-carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline oxidation to glutamate via the intermediates P5C and L-glutamate-γ-semialdehyde.
Santosh Kumar, Steven Sega, Jamie K. Lynn-Barbe, Dannika L. Harris, Jordan T. Koehn, Debbie C. Crans, Dean C. Crick   +6 more
doaj   +1 more source

Sensitive detection of gene expression in mycobacteria under replicating and non-replicating conditions using optimized far-red reporters. [PDF]

, 2010
Fluorescent reporter proteins have proven useful for imaging techniques in many organisms. We constructed optimized expression systems for several fluorescent proteins from the far-red region of the spectrum and analyzed their utility in several ...
Schreuder Lise J., Schreuder, Lise J, Ripoll Jorge, Jorge Ripoll, Schaible, UE, Muwanguzi-Karugaba, Julian, Theresa H Ward, Carroll, P, Ripoll, Jorge, Ward, Theresa H, Ulrich E Schaible, Schreuder, LJ, Ripoll, J, Parish, T, Parish Tanya, Robertson, Brian D, Tanya Parish, Schaible, Ulrich E, Lise J Schreuder, Robertson, BD, Wiles, Siouxsie, Robertson Brian D., Siouxsie Wiles, Gregory J Bancroft, Ward, TH, Brian D Robertson, Muwanguzi-Karugaba Julian, Bancroft Gregory J., Bancroft, GJ, Muwanguzi-Karugaba, J, Parish, Tanya, Wiles, S, Ward Theresa H., Bancroft, Gregory J, Schaible Ulrich E., Julian Muwanguzi-Karugaba, Carroll Paul, Wiles Siouxsie, Carroll, Paul, Paul Carroll   +39 more
core   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Determinants of innate immune responses to mycobacteria [PDF]

, 2012
Includes bibliographical references.Innate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers.
Shey, Muki Shehu
core   +1 more source

Identification of Antigens Specific to Non-Tuberculous Mycobacteria: The Mce Family of Proteins as a Target of T Cell Immune Responses [PDF]

, 2011
The lack of an effective TB vaccine hinders current efforts in combating the TB pandemic. One theory as to why BCG is less protective in tropical countries is that exposure to non-tuberculous mycobacteria (NTM) reduces BCG efficacy.
Willem A Hanekom, Anna M Checkley, Wyllie, David H., Thomas J Scriba, Hill Adrian V. S., Hanekom, Willem A., Thomas J. Scriba, McShane Helen, Hanekom Helen Mcshane, Willem A, Golubchik Tanya, Hanekom Willem A., Willem A. Hanekom, Hill, AV, Golubchik, Tanya, Anna M. Checkley, Helen McShane, Wyllie David H., Wyllie, DH, David H Wyllie, David H. Wyllie, Hanekom, WA, Scriba, Thomas J., Checkley Anna M., Scriba Thomas J., Hill, Adrian V. S., Scriba, TJ, Checkley, Anna M., Checkley, AM, Golubchik, T, Adrian V S Hill, Adrian V. S. Hill, Tanya Golubchik, McShane, H, McShane, Helen   +34 more
core   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source