Results 21 to 30 of about 67,745 (264)

Trying to See the Forest through the Trees: Deciphering the Nature of Memory Immunity to Mycobacterium tuberculosis

Frontiers in Immunology, 2018
The purpose of vaccination against tuberculosis and other diseases is to establish a heightened state of acquired specific resistance in which the memory immune response is capable of mediating an accelerated and magnified expression of protection to the
Ian M. Orme, Marcela I. Henao-Tamayo
doaj   +1 more source

Proline Dehydrogenase and Pyrroline 5 Carboxylate Dehydrogenase from Mycobacterium tuberculosis: Evidence for Substrate Channeling

Pathogens, 2023
In Mycobacterium tuberculosis, proline dehydrogenase (PruB) and ∆1-pyrroline-5-carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline oxidation to glutamate via the intermediates P5C and L-glutamate-γ-semialdehyde.
Santosh Kumar, Steven Sega, Jamie K. Lynn-Barbe, Dannika L. Harris, Jordan T. Koehn, Debbie C. Crans, Dean C. Crick   +6 more
doaj   +1 more source

Electroporation of Mycobacteria [PDF]

Journal of Visualized Experiments, 2008
High efficiency transformation is a major limitation in the study of mycobacteria. The genus Mycobacterium can be difficult to transform; this is mainly caused by the thick and waxy cell wall, but is compounded by the fact that most molecular techniques have been developed for distantly-related species such as Escherichia coli and Bacillus subtilis. In
Renan, Goude, Tanya, Parish
openaire   +3 more sources

Complexities and benefits of adopting next-generation sequencing-based tuberculosis diagnostics: a qualitative study among stakeholders in low and high-income countries

BMJ Open, 2023
Objectives To clarify perceived benefits, barriers and facilitators of Mycobacterium tuberculosis next-generation sequencing implementation in Madagascar and Canada, towards informing implementation of this diagnostic technology in public health agencies
Elysée Nouvet, Niaina Rakotosamimanana, Simon Grandjean Lapierre, Catherine-Audrey Boutin, Maxwell J Smith, Marie-Sylvianne Rabodoarivelo, Omar Mahboob   +6 more
doaj   +1 more source

Late Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses

mBio, 2023
Toxoplasma gondii oocysts, which are shed in large quantities in the feces from infected felines, are very stable in the environment, resistant to most inactivation procedures, and highly infectious. The oocyst wall provides an important physical barrier
David Arranz-Solís, David Warschkau, Benedikt T. Fabian, Frank Seeber, Jeroen P. J. Saeij   +4 more
doaj   +1 more source

Longitudinal Variations of M. tuberculosis-Induced IFN-γ Responses in HIV-Negative Pregnant Women Exposed to Tuberculosis

Frontiers in Immunology, 2021
IntroductionPregnancy triggers an alteration of the immune functions and increases the risk of developing the active tuberculosis (TB) symptoms in exposed women. The effect of pregnancy on the Mycobacterium tuberculosis-specific immune responses used for
Paulo Ranaivomanana, Rila Ratovoson, Crisca Razafimahatratra, Arimanitra Razafimahefa, Jonathan Hoffmann, Perlinot Herindrainy, Julio Rakotonirina, Niaina Rakotosamimanana   +7 more
doaj   +1 more source

Nontuberculous mycobacteria isolated from specimens of pulmonary tuberculosis suspects, Northern Tunisia: 2002–2016

BMC Infectious Diseases, 2019
Background Reports on the worldwide ascending trend of pulmonary nontuberculous mycobacteria (NTM) isolation rates and their effective role in respiratory tract infections are compelling.
Reem Gharbi, Besma Mhenni, Saloua Ben Fraj, Helmi Mardassi   +3 more
doaj   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

Usefulness of Xpert MTB/RIF Ultra for rapid diagnosis of extrapulmonary tuberculosis in Tunisia

Scientific Reports
Extrapulmonary tuberculosis (EPTB) remains a challenging diagnosis. The purpose of this study was to assess the accuracy of Xpert MTB/RIF Ultra (Cepheid, USA) for rapid diagnosis of EPTB in Tunisia.
Imen Bouzouita, Asma Ghariani, Khouloud Ben Dhaou, Sabrine Jemaeil, Leila Essaalah, Sana Bejaoui, Henda Draoui, Naceur El Marzouk, Emna Mehiri, Leila Slim-Saidi   +9 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source