Results 41 to 50 of about 94,343 (260)

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Developing whole mycobacteria cell vaccines for tuberculosis: Workshop proceedings, Max Planck Institute for Infection Biology, Berlin, Germany, July 9, 2014

, 2015
On July 9, 2014, Aeras and the Max Planck Institute for Infection Biology convened a workshop entitled “Whole Mycobacteria Cell Vaccines for Tuberculosis” at the Max Planck Institute for Infection Biology on the grounds of the Charité Hospital in Berlin,
Whole Mycobacteria Cell Vaccines for Tuberculosis Summary Group
core   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Mycobacterium bovis: From Genotyping to Genome Sequencing

Microorganisms, 2020
Mycobacterium bovis is the main pathogen of bovine, zoonotic, and wildlife tuberculosis. Despite the existence of programs for bovine tuberculosis (bTB) control in many regions, the disease remains a challenge for the veterinary and public health sectors,
Ana M. S. Guimaraes, Cristina K. Zimpel
doaj   +1 more source

Evaluation of the Speed-Oligo Mycobacteria assay for the identification of nontuberculous mycobacteria. [PDF]

, 2015
Nontuberculous mycobacteria (NTM) causing human infectious disease have become increasingly common. Rapid and accurate identification to the species level is, therefore, critical.
A. Martin, Silva, Pedro Eduardo Almeida da, Palomino, Juan Carlos, M. Cnockaert, Vandamme, Peter, André, Emmanuel, Martin, Anandi, Simon, Anne, A. Von Groll, Bastos Ramis, Ivy, Mathys, Vanessa, E. André, Cnockaert, Margo, V. Mathys, A. Simon, J.Carlos Palomino, Von Groll, Andrea, Groll, Andrea Von, Almeida da Silva, Pedro Eduardo, E. Tortoli, P. Vandamme, Tortoli, Enrico, I. Bastos Ramis, P.Eduardo Al da Silva, Ramis, Ivy Bastos   +24 more
core   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Systemic Rasamsonia argillacea infection in a German Shepherd dog

Medical Mycology Case Reports
This case report describes a disseminated Rasamsonia (R.) argillacea infection in a German shepherd dog involving internal and external lymph nodes, abdominal organs and one eye. R. argillacea is a member of the R. argillacea species complex, which is an
Louisa Schmidt, Sebastian Reusch, Ilka McCormick-Smith, Jasmin Gerkrath, Martin Peters, Volker Rickerts   +5 more
doaj   +1 more source

No life without death--apoptosis as prerequisite for T cell activation.

, 2005
The orchestrated death of infected cells is key to our understanding of CD8 T cell activation against pathogens. Most intracellular bacteria including Mycobacterium tuberculosis, the etiologic agent of tuberculosis, remain enclosed in phagosomes of ...
Winau, F, Schaible, UE, Hegasy, G, Kaufmann, SHE   +3 more
core   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Establishing translational performance standards for TB therapy using rifampicin-based regimens in a male and female high-burden murine model

BMC Microbiology
Background Establishing efficacy benchmarks in preclinical tuberculosis (TB) models is essential for optimizing and prioritizing therapeutic regimens.
Jason E. Cummings, Lisa Woolhiser, Barbara Graham, Gregory T. Robertson, M. Nurul Islam, Richard A. Slayden   +5 more
doaj   +1 more source