Results 61 to 70 of about 125,364 (304)

Mycobacterium avium Infection in a C3HeB/FeJ Mouse Model

Frontiers in Microbiology, 2019
Infections caused by Mycobacterium avium complex (MAC) species are increasing worldwide, resulting in a serious public health problem. Patients with MAC lung disease face an arduous journey of a prolonged multidrug regimen that is often poorly tolerated ...
Deepshikha Verma, Megan Stapleton, Jake Gadwa, Kridakorn Vongtongsalee, Alan R. Schenkel, Edward D. Chan, Edward D. Chan, Edward D. Chan, Diane Ordway   +8 more
doaj   +1 more source

Increased Virulence of Outer Membrane Porin Mutants of Mycobacterium abscessus

Frontiers in Microbiology, 2021
Chronic pulmonary infections caused by non-tuberculous mycobacteria of the Mycobacterium abscessus complex (MABSC) are emerging as a global health problem and pose a threat to susceptible individuals with structural lung disease such as cystic fibrosis ...
Vinicius C. N. de Moura, Deepshikha Verma, Isobel Everall, Isobel Everall, Karen P. Brown, Karen P. Brown, Juan M. Belardinelli, Crystal Shanley, Megan Stapleton, Julian Parkhill, R. Andres Floto, R. Andres Floto, Diane J. Ordway, Mary Jackson   +13 more
doaj   +1 more source

Identification and structural characterisation of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiAmutant [PDF]

, 2007
Arabinan polysaccharide side-chains are present in both Mycobacterium tuberculosis and Corynebacterium glutamicum in the heteropolysaccharide arabinogalactan (AG), and in M. tuberculosis in the lipoglycan, lipoarabinomannan (LAM).
Alderwick, Luke J., Besra, Gurdyal S, Dell, Anne, Eggeling, Lothar, Gilleron, Martine, Giordano, Assunta, Hitchen, Paul, Krumbach, Karin, Mishra, Arun K., Morris, Howard R., Nigou, Jerome, Tatituri, Raju Venkata Veera   +11 more
core  

The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition [PDF]

, 2016
M. tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding
Barry III, CE, Brandenburg, J, Prosser, G, Reiling, N, Wilkinson, KA, Wilkinson, RJ   +5 more
core   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Establishing translational performance standards for TB therapy using rifampicin-based regimens in a male and female high-burden murine model

BMC Microbiology
Background Establishing efficacy benchmarks in preclinical tuberculosis (TB) models is essential for optimizing and prioritizing therapeutic regimens.
Jason E. Cummings, Lisa Woolhiser, Barbara Graham, Gregory T. Robertson, M. Nurul Islam, Richard A. Slayden   +5 more
doaj   +1 more source

Screening vaccine formulations for biological activity using fresh human whole blood. [PDF]

, 2014
Understanding the relevant biological activity of any pharmaceutical formulation destined for human use is crucial. For vaccine-based formulations, activity must reflect the expected immune response, while for non-vaccine therapeutic agents, such as ...
Aboutorabian, Sepideh, Ausar, Salvador F, Brookes, Roger H, Dockrell, Hazel M, Ha, Yukyung, Hakimi, Jalil, Hasija, Manvi, Rahman, Nausheen, Smith, Steven G, Todryk, Stephen M   +9 more
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Nontuberculous Mycobacteria in Portugal: Trends from the last decade

Pulmonology
Introduction and objectives Nontuberculous mycobacteria (NTM) are opportunistic human pathogens found in the environment. The transmission seems to be associated with inhalation of aerosol droplets, ingestion or trauma events.
A. Santos, S. Carneiro, A. Silva, J.P. Gomes, R. Macedo   +4 more
doaj   +1 more source

Mycobacteria and sarcoidosis [PDF]

Thorax, 1997
Background. Acid fast cell wall deficient forms (CWDF) of bacteria have been grown from blood, bronchial washings, and ocular anterior chamber fluid from patients with sarcoidosis. A monoclonal antibody raised against Mycobacterium tuberculosis whole cell antigen (H37RV) was used to characterise further CWDF grown from the blood of patients with ...
O M, Kon, R M, du Bois
openaire   +2 more sources