Results 51 to 60 of about 94,343 (260)
Host Lipid Mediators in Leprosy: The Hypothesized Contributions to Pathogenesis
Frontiers in Immunology, 2018 The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host’s immune response against Mycobacterium leprae, the etiological agent of leprosy.
Carlos A. M. Silva, John T. Belisle
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Increased Virulence of Outer Membrane Porin Mutants of Mycobacterium abscessus
Frontiers in Microbiology, 2021 Chronic pulmonary infections caused by non-tuberculous mycobacteria of the Mycobacterium abscessus complex (MABSC) are emerging as a global health problem and pose a threat to susceptible individuals with structural lung disease such as cystic fibrosis ...
Vinicius C. N. de Moura +13 more
doaj +1 more source
Advanced Science, EarlyView.Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang +12 more
wiley +1 more source
Mycobacterium avium Infection in a C3HeB/FeJ Mouse Model
Frontiers in Microbiology, 2019 Infections caused by Mycobacterium avium complex (MAC) species are increasing worldwide, resulting in a serious public health problem. Patients with MAC lung disease face an arduous journey of a prolonged multidrug regimen that is often poorly tolerated ...
Deepshikha Verma +8 more
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Identification of aquatic mycobacteria based on sequence analysis of the 16S-23S rRNA internal transcribed spacer region [PDF]
, 2018 Purpose. Mycobacteria are common causative agents of bacterial infections in many species of freshwater and marine fish. Identification of mycobacteria to the species level based on phenotypic tests is inappropriate and time consuming.
Pourahmad, Fazel +7 more
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Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics
Advanced Science, EarlyView.Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan +5 more
wiley +1 more source
Cigarette smoke and human pulmonary immune responses to mycobacteria [PDF]
, 2011 Recent epidemiological evidence suggests that up to 15% of worldwide tuberculosis (TB) cases may be attributable to tobacco smoking. The aim of the studies reported here was to gain insights into the effects of exposure to cigarette smoke on human cells ...
Van Zyl-Smit, Richard Nellis
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Nontuberculous Mycobacteria in Portugal: Trends from the last decade
PulmonologyIntroduction and objectives Nontuberculous mycobacteria (NTM) are opportunistic human pathogens found in the environment. The transmission seems to be associated with inhalation of aerosol droplets, ingestion or trauma events.
A. Santos +4 more
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Distribution of nontuberculous mycobacteria species by year, Shanghai, 2008–2012.
, 2014 Abbreviations: NTM, nontuberculous mycobacteria; RGM, rapidly growing mycobacteria; SGM, slowly growing mycobacteria.Distribution of nontuberculous mycobacteria species by year, Shanghai, 2008–2012.
Yangyi Zhang (646040) +7 more
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Advanced Science, EarlyView.Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie +24 more
wiley +1 more source