Results 1 to 10 of about 17,674,253 (266)

High burden of kidney involvement in neuronal intranuclear inclusion disease [PDF]

Frontiers in Neurology
BackgroundNeuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder caused by NOTCH2NLC GGC repeat expansions. Renal involvement in NIID is not well understood.MethodsWe conducted a cross-sectional study of 96 genetically ...
Zhenxian Hu, Zhenxian Hu, Hongfei Tai, Hongfei Tai, An Wang, An Wang, Yi Zhou, Yi Zhou, Hua Pan, Hua Pan, Zaiqiang Zhang, Zaiqiang Zhang   +11 more
doaj   +2 more sources

Pretomanid vs delamanid in a bedaquiline-linezolid regimen: efficacy in a high-burden tuberculosis mouse model [PDF]

Antimicrobial Agents and Chemotherapy
The bedaquiline, pretomanid, and linezolid (BPaL) regimen has shown significant efficacy in treating patients with multidrug-resistant and extensively drug-resistant tuberculosis.
Jason E. Cummings, Lisa K. Woolhiser, Vincent Guglielmi, Ashely Romano, Samantha Pauly, Matt Zimmerman, Firat Kaya, Nicholas D. Walter, Gregory T. Robertson, Richard A. Slayden   +9 more
doaj   +2 more sources

Estimating the changing burden of disease attributable to alcohol use in South Africa for 2000, 2006 and 2012

South African Medical Journal, 2022
Background. Alcohol use was one of the leading contributors to South Africa (SA)’s disease burden in 2000, accounting for 7% of deaths and disability-adjusted life years (DALYs) in the first South African Comparative Risk Assessment Study (SACRA1 ...
R Matzopoulos, A Cois, C Probst, C D H Parry, N Vellios, K Sorsdahl, J D Joubert, V Pillay-van Wyk, D Bradshaw, R Pacella   +9 more
doaj   +1 more source

High burden to high impact: Strengthening services for malaria elimination

Environmental Disease, 2021
Malaria is a major public health concern, and for many decades, consistent efforts have been taken to reduce the incidence of the disease as well as the associated deaths.
Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava   +1 more
doaj   +1 more source

Global and regional estimates of clinical and economic burden of low back pain in high-income countries: a systematic review and meta-analysis

Frontiers in Public Health, 2023
IntroductionLow back pain (LBP) is a common health problem, and the leading cause of activity limitation and work absence among people of all ages and socioeconomic strata.
Francis Fatoye, Francis Fatoye, Tadesse Gebrye, Cormac G. Ryan, Ushotanefe Useh, Chidozie Mbada   +5 more
doaj   +1 more source

High levels of caregiver burden in Prader-Willi syndrome. [PDF]

PLoS ONE, 2018
Prader-Willi syndrome (PWS) is a rare genetic neurodevelopmental disorder that is characterized by hyperphagia, developmental delay, incomplete sexual development, mild-to-moderate intellectual disability, and a variety of challenging behavioral and ...
Nathalie Kayadjanian, Lauren Schwartz, Evan Farrar, Katherine Anne Comtois, Theresa V Strong   +4 more
doaj   +1 more source

Identifying US County-level characteristics associated with high COVID-19 burden

BMC Public Health, 2021
Background Identifying county-level characteristics associated with high coronavirus 2019 (COVID-19) burden can help allow for data-driven, equitable allocation of public health intervention resources and reduce burdens on health care systems.
Daniel Li, Sheila M. Gaynor, Corbin Quick, Jarvis T. Chen, Briana J. K. Stephenson, Brent A. Coull, Xihong Lin   +6 more
doaj   +1 more source

Cardiac sympathetic burden reflects Parkinson disease burden, regardless of high or low orthostatic blood pressure changes

npj Parkinson's Disease, 2021
Reduced uptake of 123I-meta-iodobenzylguanidine (123I-MIBG) and orthostatic hypotension (OH) are independently associated with worse clinical outcomes of Parkinson’s disease (PD). However, their interactive influence on PD has not been studied.
Sang-Won Yoo, Joong-Seok Kim, Yoon-Sang Oh, Dong-Woo Ryu, Seunggyun Ha, Ji-Yeon Yoo, Kwang-Soo Lee   +6 more
doaj   +1 more source

Estimating the changing burden of disease attributable to high fasting plasma glucose in South Africa for 2000, 2006 and 2012

South African Medical Journal, 2022
Background. Worldwide, higher-than-optimal fasting plasma glucose (FPG) is among the leading modifiable risk factors associated with all- cause mortality and disability-adjusted life years (DALYs) due to the direct sequelae of diabetes and the ...
V Pillay van-Wyk, A Cois, A P Kengne, R A Roomaney, N Levitt, E B Turawa, N Abdelatief, I Neethling, O F Awotiwon, B Nojilana, J D Joubert, R Pacella, D Bradshaw   +12 more
doaj   +1 more source

Epidemiology of extrapulmonary tuberculosis in high-burden regions

Туберкулез и болезни лёгких, 2020
The objective of the study: to assess the structure of extrapulmonary tuberculosis in two high-burden regions (Siberia, the Far East of the Russian Federation, and the Republic of Tajikistan), with the consideration of HIV status, gender, and age of ...
E. V. Kulchavenya, M. M. Merganov, F. R. Sharipov   +2 more
doaj   +1 more source