Results 41 to 50 of about 3,506 (234)

Expression of a barley cystatin gene in maize enhances resistance against phytophagous mites by altering their cysteine-proteases

, 2010
Phytocystatins are inhibitors of cysteine-proteases from plants putatively involved in plant defence based on their capability of inhibit heterologous enzymes.
Diaz Rodriguez, Isabel, Pedro Castañera, Koreen Ramessar, Castañera, Pedro, Laura Carrillo, Inés Cambra, Carrillo Gil, Laura, Ortego, Felix, Isabel Díaz, Cambra Marin, Ines, Manuel Martinez, Ramessar, Koreen, Martinez Muñoz, Manuel, Felix Ortego   +13 more
core   +1 more source

Cystatins and cancer

Frontiers in Bioscience, 2009
Cystatins are natural cysteine protease inhibitors which belong to a superfamily of proteins with wide occurrence in tissues. The cystatins have been shown to play multiple roles in normal and disease processes. In many different cancers the cathepsins, enzymes inhibited by cystatins, are elevated and participate in tumor growth and invasion.
openaire   +2 more sources

Biomarkers of Sarcopenia: Current Status and Future Perspectives

AGING MEDICINE, EarlyView.
In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo, Wenhan Li, Yi Zhang, Mengchen Liu, Kemeng Zhang, Sui Huang, Ping He   +6 more
wiley   +1 more source

Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms

, 2011
Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines, Sánchez-Monge Laguna de Rins, Rosa, Diaz Rodriguez, Isabel, Herrero, Ignacio, Carrillo Gil, Laura, Martinez Muñoz, Manuel   +5 more
core   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Cystatin C in Alzheimer's disease [PDF]

Frontiers in Molecular Neuroscience, 2012
Changes in expression and secretion levels of cystatin C (CysC) in the brain in various neurological disorders and in animal models of neurodegeneration underscore a role for CysC in these conditions. A polymorphism in the CysC gene (CST3) is linked to increased risk for Alzheimer's disease (AD).
Kaur, Gurjinder, Levy, Efrat
openaire   +3 more sources

Cysteine Cathepsins in Tumor-Associated Immune Cells

Frontiers in Immunology, 2019
Cysteine cathepsins are key regulators of the innate and adaptive arms of the immune system. Their expression, activity, and subcellular localization are associated with the distinct development and differentiation stages of immune cells.
Tanja Jakoš, Anja Pišlar, Anahid Jewett, Janko Kos, Janko Kos   +4 more
doaj   +1 more source

TcCYPR04, a Cacao Papain-Like Cysteine-Protease Detected in Senescent and Necrotic Tissues Interacts with a Cystatin TcCYS4. [PDF]

PLoS ONE, 2015
The interaction amongst papain-like cysteine-proteases (PLCP) and their substrates and inhibitors, such as cystatins, can be perceived as part of the molecular battlefield in plant-pathogen interaction.
Thyago Hermylly Santana Cardoso, Ana Camila Oliveira Freitas, Bruno Silva Andrade, Aurizangela Oliveira de Sousa, André da Silva Santiago, Daniela Martins Koop, Karina Peres Gramacho, Fátima Cerqueira Alvim, Fabienne Micheli, Carlos Priminho Pirovani   +9 more
doaj   +1 more source

Tick salivary protein Cystatin: structure, anti-inflammation and molecular mechanism

Ticks and Tick-Borne Diseases
Ticks are blood-sucking ectoparasites that secrete immunomodulatory substances in saliva to hosts during engorging. Cystatins, a tick salivary protein and natural inhibitor of Cathepsins, are attracting growing interest globally because of the ...
Xin Gao, Yuan Tian, Zi-ling Liu, Dan Li, Jia-jun Liu, Guang-xu Yu, De-yong Duan, Tao Peng, Tian-yin Cheng, Lei Liu   +9 more
doaj   +1 more source

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source