Results 51 to 60 of about 5,771 (244)

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source

Physical exercise stimulates salivary secretion of cystatins.

PLoS ONE, 2019
Physical exercise is known to activate the sympathetic nervous system, which influences the production of saliva from salivary glands. Our examination of saliva collected from highly trained athletes before and after a number of physical competititions ...
Marcelo de Lima Sant'Anna, Leandro Teixeira Oliveira, Diego Viana Gomes, Sergio Tadeu Farinha Marques, D William Provance, Martha Meriwether Sorenson, Verônica Pinto Salerno   +6 more
doaj   +1 more source

Control of active B and L cathepsins in tissues of colorectal cancer using cystatins isolated from chicken egg proteins: <i>in vitro</i> studies

Folia Histochemica et Cytobiologica, 2012
The activity of cysteine peptidases (cathepsins B and L) was estimated in homogenates of tissues sampled during surgery from 60 patients operated due to colorectal tumors.
Julia Rudno-Rudzinska, Robert Tarnawa, Jerzy Rudnicki, Maciej Siewinski, Zygmunt Grzebieniak, Wojciech Kielan, Andrzej Hap, Anil Kumar Agrawal   +7 more
doaj   +1 more source

The genome of Strongyloides spp. gives insights into protein families with a putative role in nematode parasitism [PDF]

, 2016
SUMMARYParasitic nematodes are important and abundant parasites adapted to live a parasitic lifestyle, with these adaptations all aimed at facilitating their survival and reproduction in their hosts.
Hunt, Vicky L, Selkirk, Murray E, Tsai, Isheng J, Viney, Mark   +3 more
core   +2 more sources

Cystatin C and Cardiovascular Risk [PDF]

Clinical Chemistry, 2009
Abstract Background: Patients with chronic kidney disease (CKD) are at high risk for developing cardiovascular disease (CVD) and cardiovascular events. Cystatin C, a protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal function, particularly to detect ...
TAGLIERI, NEVIO, Koenig W, Kaski C.
openaire   +6 more sources

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

Analysis of the transcriptome of adult Dictyocaulus filaria and comparison with Dictyocaulus viviparus, with a focus on molecules involved in host–parasite interactions [PDF]

, 2014
Parasitic nematodes cause diseases of major economic importance in animals. Key representatives are species of Dictyocaulus (=lungworms), which cause bronchitis (=dictyocaulosis, commonly known as “husk”) and have a major adverse impact on the health of ...
Gasser, Robin B., Hofmann, Andreas, Jex, Aaron R., Korhonen, Pasi K., Mangiola, Stefano, Mitreva, Makedonka, Scheerlinck, Jean-Pierre, Sternberg, Paul W., Strube, Christina, Young, Neil D.   +9 more
core   +1 more source

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, EarlyView.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Cysteine Cathepsins in Tumor-Associated Immune Cells

Frontiers in Immunology, 2019
Cysteine cathepsins are key regulators of the innate and adaptive arms of the immune system. Their expression, activity, and subcellular localization are associated with the distinct development and differentiation stages of immune cells.
Tanja Jakoš, Anja Pišlar, Anahid Jewett, Janko Kos, Janko Kos   +4 more
doaj   +1 more source