Results 51 to 60 of about 3,702 (189)
Cysteine Cathepsins in Tumor-Associated Immune Cells
Frontiers in Immunology, 2019 Cysteine cathepsins are key regulators of the innate and adaptive arms of the immune system. Their expression, activity, and subcellular localization are associated with the distinct development and differentiation stages of immune cells.
Tanja Jakoš +4 more
doaj +1 more source
Secreted cystatins decrease proliferation and enhance apoptosis of human leukemic cells
FEBS Open Bio, 2020 Cysteine proteases are implicated in proteolysis events favoring cancer cell growth, spread, and death by apoptosis. Herein, we have studied whether the net growth and survival of the leukemic cell lines Jurkat, U937, and HL‐60 are affected by external ...
Samar Hunaiti +4 more
doaj +1 more source
Laryngoscope Investigative Otolaryngology, 2023 Background Pharyngocutaneous fistula (PCF) and salivary leaks are well known complications of head and neck surgery. The medical management of PCF has included the use of octreotide without a well‐defined understanding of its therapeutic mechanism.
Jonathan Cohen +7 more
doaj +1 more source
Loop replacement design : a new way to improve potency of plant cystatins [PDF]
, 2022 Comment on https://doi.org/10.1111/febs.16288Plant cystatins function as competitive inhibitors of cysteine proteases. Similar to other defence proteins, cystatins include hypervariable, positively selected amino acid sites presumably impacting their ...
Kunert, Karl J., Pillay, Priyen
core +1 more source
BMC Oral Health, 2022 Background Saliva possesses antiviral activity, with submandibular-sublingual (SMSL) saliva having higher antiviral activity than parotid saliva.
Kenkichi Yamamoto, Shinji Yamamoto
doaj +1 more source
Cystatin C in Alzheimer's disease [PDF]
Frontiers in Molecular Neuroscience, 2012 Changes in expression and secretion levels of cystatin C (CysC) in the brain in various neurological disorders and in animal models of neurodegeneration underscore a role for CysC in these conditions. A polymorphism in the CysC gene (CST3) is linked to increased risk for Alzheimer's disease (AD).
Kaur, Gurjinder, Levy, Efrat
openaire +3 more sources
Acta Chimica Slovenica, 2019 The majority of lysosomal cysteine cathepsins are ubiquitously expressed enzymes. However, some of them differ in their specific cell or tissue distribution and substrate specificity, suggesting their involvement in determining normal cellular processes,
Vito Turk +3 more
doaj +1 more source
Nitric oxide (NO) regulates the expression of single-domain cystatins in glycine max (soybean) [PDF]
, 2013 Plant cystatins inhibit cysteine proteases and are important in regulating plant development and plant responses to biotic and abiotic stress. Furthermore, nitric oxide plays a signaling role in regulating plant responses to developmental processes ...
Adams, Ruqaiyah +3 more
core +2 more sources
Mechanism of action of mammalian cystatins [PDF]
, 2003 Mammalian cystatins are tight-binding, reversible inhibitors of potentially destructive cysteine proteases, both endogenous and exogenous. The N-terminal region residues, Ile2 and especially Pro3, and the second binding loop residues, Leu73 and to some ...
Pavlova, Alona
core +1 more source
Modelling family 2 cystatins and their interaction with papain
, 2013 Cystatins are extensively studied cysteine protease inhibitors, found in wide range of organisms with highly conserved structural folds. S-type of cystatins is well known for their abundance in saliva, high selectivity and poorer activity towards host ...
Alpana Seal (472840) +2 more
core +1 more source