Results 71 to 80 of about 3,702 (189)

A five-residue motif for the design of domain swapping in proteins

Nature Communications, 2019
Designing interfaces that can induce protein-protein interactions is a challenging problem. Here the authors show that a five amino acid sequence known to mediate domain swapping in cystatins can drive oligomerization when grafted onto functionally and ...
Neha Nandwani, Parag Surana, Hitendra Negi, Nahren M. Mascarenhas, Jayant B. Udgaonkar, Ranabir Das, Shachi Gosavi   +6 more
doaj   +1 more source

The origin and evolution of plant cystatins and their target cysteine proteinases indicate a complex functional relationship

BMC Evolutionary Biology, 2008
Background Cystatins and their putative targets, the families of cysteine proteinases C1A and C13 play key roles in plants. Comparative genomic analyses are powerful tools to obtain valuable insights into the conservation and evolution of the proteinases
Diaz Isabel, Martinez Manuel
doaj   +1 more source

Ectromelia virus suppresses expression of cathepsins and cystatins in conventional dendritic cells to efficiently execute the replication process

BMC Microbiology, 2019
Background Cathepsins are a group of endosomal proteases present in many cells including dendritic cells (DCs). The activity of cathepsins is regulated by their endogenous inhibitors – cystatins.
Magdalena Bossowska-Nowicka, Matylda B. Mielcarska, Marta Romaniewicz, Monika M. Kaczmarek, Karolina P. Gregorczyk-Zboroch, Justyna Struzik, Marta Grodzik, Małgorzata M. Gieryńska, Felix N. Toka, Lidia Szulc-Dąbrowska   +9 more
doaj   +1 more source

Cloning and characterisation of novel cystatins from elapid snake venom glands

, 2011
Snake venoms contain a complex mixture of polypeptides that modulate prey homeostatic mechanisms through highly specific and targeted interactions. In this study we have identified and characterised cystatin-like cysteine-protease inhibitors from elapid ...
Renée Richards, Masci, Paul P., Martin F. Lavin, Lavin, Martin F., Paul P. Masci, St Pierre, Liam, Trabi, Manuela, de Jersey, John, Liam St Pierre, Manuela Trabi, Johnson, Lambro A., John de Jersey, Lambro A. Johnson, Richards, Renee   +13 more
core   +1 more source

Leishmania infantum: Antiproliferative effect of recombinant plant cystatins on promastigotes and intracellular amastigotes estimated by direct counting and real-time PCR

, 2009
Two recombinant barley cystatins, HvCPI5 and HvCPI6, have been tested in vitro against promastigotes and intracellular amastigotes of Leishmania infantum in the J774 monocytic cell line. Toxicity of cystatins for J774 cells was also determined.
Alunda Rodríguez, José María, Ordóñez Gutiérrez, Lara, Martínez Orts, Mónica, Díaz, I., Mendez, S., Rubio-Somoza, I.   +5 more
core   +1 more source

Structural and Functional Studies on Human Type 2 Cystatins

, 2002
Proteolytic enzymes are enzymes that hydrolyze peptide bonds in peptides and proteins. This ability to carry out protein degradation is essential for many cellular and extracellular processes that occur in all living organisms.
Alvarez Fernandez, Marcia
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BETA2-STRAND OF SALIVARY CYSTATINS: A "CHEMELEON SEQUENCE"

, 2009
Secondary structure prediction of salivary cystatins S, SA, and SN carried out by several methods label the 39–58 sequence (b2-strand) as predominantly a-helical.
PETRUZZELLI, Raffaele, VITALI A, DE ROSA MC, CARELLI ALINOVI C   +3 more
core  

Cystatins of filarial nematodes up-regulate the nitric oxide production of interferon-γ-activated murine macrophages

, 2002
Cystatins of two filarial nematodes were studied with regard to their capacity to up-regulate the production of nitric oxide (NO) in vitro, and the effects were analysed. Recombinant cystatin of the human pathogenic filaria Onchocerca volvulus and of the
Schönemeyer, Annett, Susanne Hartmann, Sonnenburg, Bettina, Lucius, Richard, Bettina Sonnenburg, Hartmann, Susanne, Vray, Bernard, Bernard Vray, Richard Lucius, Annett Schonemeyer   +9 more
core   +1 more source

Evolutionary Analysis of Cystatins of Early-Emerging Metazoans Reveals a Novel Subtype in Parasitic Cnidarians

, 2022
The evolutionary aspects of cystatins are greatly underexplored in early-emerging metazoans. Thus, we surveyed the gene organization, protein architecture, and phylogeny of cystatin homologues mined from 110 genomes and the transcriptomes of 58 basal ...
KYSLÍK, Jiří
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The effect of tick cystatins on TLR - induced maturation of myeloid dendritic cells

, 2014
Tick saliva contains a lot of molecules with antihemostatic and immunosupressive effects.The goal of this thesis is to test the effects of tick salivary cystatins from I.ricinus and I.scapularis on TLR - induced maturation of bone-marrow derived ...
NERADOVÁ, Hana
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