Results 81 to 90 of about 3,506 (234)
Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang +3 more
wiley +1 more source
Phylogenomic analysis of the cystatin superfamily in eukaryotes and prokaryotes
BMC Evolutionary Biology, 2009 Background The cystatin superfamily comprises cysteine protease inhibitors that play key regulatory roles in protein degradation processes. Although they have been the subject of many studies, little is known about their genesis, evolution and functional
Turk Vito, Kordiš Dušan
doaj +1 more source
Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms
Allergy, EarlyView.Short‐term exposure to SDS rapidly disrupts human skin barrier integrity within minutes, as detected by real‐time electrical impedance spectroscopy. SDS‐induced barrier dysfunction is driven by oxidative stress, leading to suppression of immune/barrier mediators and activation of stress, lipid remodeling, and epidermal differentiation pathways ...
Manru Li +10 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley +1 more source
, 2010 Cystatins are present in mammals, birds, fish, insects, plants, fungi and protozoa and constitute a large protein family, with most members sharing a cysteine protease inhibitory function.
Vogel, Lotte K +6 more
core +2 more sources
Innate immune response in brain, NF-kappa B signaling and cystatins
Frontiers in Molecular Neuroscience, 2015 Recently several reports have demonstrated that innate immune response and inflammation have an important role in major neurodegenerative diseases.
Natasa eKOPITAR-JERALA
doaj +1 more source
Mechanism of action of mammalian cystatins [PDF]
, 2003 Mammalian cystatins are tight-binding, reversible inhibitors of potentially destructive cysteine proteases, both endogenous and exogenous. The N-terminal region residues, Ile2 and especially Pro3, and the second binding loop residues, Leu73 and to some ...
Pavlova, Alona
core
, 2023 Members of the cystatin family are important inhibitors of cathepsin-type cysteine proteases and are involved in a number of pathologies. Parasite cystatins are attractive target molecules for parasite control, but our knowledge about them is still ...
Buša, Michal
core
Cell Proliferation, EarlyView.Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) promotes obstructive nephropathy progression by activating the β‐catenin signalling pathway, driving M2 macrophage polarisation, migration and fibrogenic gene expression. targeted inhibition of TREM2 thus represents a promising novel strategy against renal fibrosis.
Jia Wei +7 more
wiley +1 more source
BMC Biology, 2008 Background In pathogens, certain genes encoding proteins that directly interact with host defences coevolve with their host and are subject to positive selection.
Purisima Enrico O +7 more
doaj +1 more source