Results 101 to 110 of about 5,771 (244)

Changes in the salivary protein profile of morbidly obese women either previously subjected to bariatric surgery or not [PDF]

open access: yes, 2015
Saliva is a non-invasive source of biomarkers useful in the study of physiological mechanisms. Moreover, this fluid has diverse functions, among which food perception and ingestion, making it particularly suitable for the study of obesity.
Amado, Francisco   +7 more
core   +1 more source

Estimated Glomerular Filtration Rate Change and Heart Failure Events With GLP‐1 Receptor Agonists: A Meta‐Analysis and Meta‐Regression of Randomised Controlled Trials

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To examine whether on‐treatment changes in kidney function and cardiometabolic markers are associated with the magnitude of heart failure (HF) risk reduction across large‐scale trials of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs).
Masashi Hasebe   +5 more
wiley   +1 more source

Viral cystatin evolution and three-dimensional structure modelling: A case of directional selection acting on a viral protein involved in a host-parasitoid interaction

open access: yesBMC Biology, 2008
Background In pathogens, certain genes encoding proteins that directly interact with host defences coevolve with their host and are subject to positive selection.
Purisima Enrico O   +7 more
doaj   +1 more source

Genome-wide analysis of excretory/secretory proteins in Echinococcus multilocularis: insights into functional characteristics of the tapeworm secretome [PDF]

open access: yes, 2015
Venn diagrams of expression levels of ES protein coding genes in different developments. The venn diagrams are displayed for: the genes that have expressions (A), the genes with very high expression levels (B), the genes with high expression levels (C ...
Shuai Wang, Wei Wei, Xuepeng Cai
core   +8 more sources

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

open access: yesThe FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Supragingival calculus: Formation and control [PDF]

open access: yes, 2002
Dental calculus is composed of inorganic components and organic matrix. Brushite, dicalcium phosphate dihydrate, octacalcium phosphate, hydroxyapatite, and whitlockite form the mineral part of dental calculus.
Jin, Y, Yip, HK
core   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

open access: yesThe FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou   +4 more
wiley   +1 more source

A five-residue motif for the design of domain swapping in proteins

open access: yesNature Communications, 2019
Designing interfaces that can induce protein-protein interactions is a challenging problem. Here the authors show that a five amino acid sequence known to mediate domain swapping in cystatins can drive oligomerization when grafted onto functionally and ...
Neha Nandwani   +6 more
doaj   +1 more source

The origin and evolution of plant cystatins and their target cysteine proteinases indicate a complex functional relationship

open access: yesBMC Evolutionary Biology, 2008
Background Cystatins and their putative targets, the families of cysteine proteinases C1A and C13 play key roles in plants. Comparative genomic analyses are powerful tools to obtain valuable insights into the conservation and evolution of the proteinases
Diaz Isabel, Martinez Manuel
doaj   +1 more source

Salivary proteome and glucose levels are related with sweet taste sensitivity in young adults [PDF]

open access: yes, 2017
Sweet taste plays a critical role in determining food preferences and choices. Similar to what happens for other oral sensations, individuals differ in their sensitivity for sweet taste and these inter-individual differences may be responsible for ...
Amado, F   +5 more
core   +1 more source

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