Results 121 to 130 of about 5,771 (244)
Experimental Physiology, EarlyView.Abstract Circulating cell‐free DNA (cfDNA), circulating tumour DNA (ctDNA) and inflammatory cytokines have prognostic and predictive value in oncology. However, the effects of acute exercise on cfDNA levels are unknown. Here, we explore the kinetics of cfDNA, ctDNA and cytokines upon an incremental exercise test in a pilot cohort of cancer patients ...
Elmo W. I. Neuberger +10 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1457-1472, May 2026.Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo +10 more
wiley +1 more source
Teriparatide in Two Patients With Mucopolysaccharidosis Type IVB
JIMD Reports, Volume 67, Issue 3, May 2026.ABSTRACT Mucopolysaccharidosis Type IV is a multisystem lysosomal storage disease characterized by severe skeletal dysplasia resulting from impaired degradation of the glycosaminoglycans keratan sulfate and chondroitin‐6‐sulfate. The condition is classified into Types A and B based on the underlying enzyme deficiency.
Mark Wijnen +5 more
wiley +1 more source
Protein Science, Volume 35, Issue 5, May 2026.Abstract Legumain is a lysosomal cysteine protease that plays a central role in antigen processing for MHC class II presentation. Beyond its canonical proteolytic activity, legumain can also function as a peptide ligase or transpeptidase. This non‐canonical activity becomes particularly relevant under pathophysiological conditions such as cancer and ...
Rupert Klaushofer +3 more
wiley +1 more source
Protein Science, Volume 35, Issue 5, May 2026.Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney +12 more
wiley +1 more source
Evaluating Protein Enrichment Methods to Improve Biomarker Discovery in Equine Cerebrospinal Fluid
Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.Here, we compared two protein enrichment methods—ProteoMiner Small‐Capacity and PreOmics Enrich‐iST—for proteomic analysis of equine cerebrospinal fluid (CSF). PreOmics Enrich‐iST achieved superior depletion of high‐abundance proteins and identified a greater number of low‐abundance, neuropathology‐relevant proteins than ProteoMiner or native digestion.
Foti Federico +5 more
wiley +1 more source
Clinical Physiology and Functional Imaging, Volume 46, Issue 3, May 2026.Abstract This study evaluates mannitol as a clearance marker for measuring glomerular filtration rate (GFR) in outpatients with chronic kidney disease (CKD). Multi‐sample iohexol clearance served as the reference method. Twenty patients with CKD, stages 3–4, received bolus injections of both clearance markers simultaneously.
Katalin Kiss +3 more
wiley +1 more source
Proteolysis of defensive proteins in peritonitis exudate [PDF]
, 1991 Assfalg-Machleidt, Irmgard +4 more
core +1 more source
Rapid improvement of renal microcirculatory homeostasis by liraglutide following diabetes induction
Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4066-4081, May 2026.Abstract Aims Renal microvascular dysfunction is a central driver of diabetic kidney disease, yet the potential for rapid therapeutic reversal remains obscure. We investigated the effect of short‐term liraglutide on early changes in the renal microcirculation post‐induction of diabetes.
Yuan Li +8 more
wiley +1 more source
Cysteine proteinases and their inhibitors - A traditional topic of the Portoroz conferences [PDF]
, 2001 Fritz, H., Jochum, M.
core +1 more source