Results 31 to 40 of about 5,771 (244)

Rhipicephalus microplus and Ixodes ovatus cystatins in tick blood digestion and evasion of host immune response

Parasites & Vectors, 2015
Background Cystatins are a group of cysteine protease inhibitors responsible for physiological proteolysis regulation and present in a wide range of organisms. Studies about this class of inhibitors in parasites have contributed to clarify their roles in
Luís Fernando Parizi, Gabriela Alves Sabadin, María Fernanda Alzugaray, Adriana Seixas, Carlos Logullo, Satoru Konnai, Kazuhiko Ohashi, Aoi Masuda, Itabajara da Silva Vaz Jr   +8 more
doaj   +1 more source

Modulation of Cystatin F in Human Macrophages Impacts Cathepsin-Driven Killing of Multidrug-Resistant Mycobacterium tuberculosis

Microorganisms, 2023
Tuberculosis (TB) treatment relies primarily on 70-year-old drugs, and prophylaxis suffers from the lack of an effective vaccine. Among the 10 million people exhibiting disease symptoms yearly, 450,000 have multidrug or extensively drug-resistant (MDR or
Manoj Mandal, David Pires, Maria João Catalão, José Miguel Azevedo-Pereira, Elsa Anes   +4 more
doaj   +1 more source

Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes [PDF]

, 2012
<p>Background: Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-driven immune effectors, but that have evolved to withstand immune attack and establish chronic infections by suppressing host immunity. As a consequence, the
AB Fredriksen, AB Pedersen, AE O'Connell, AE Schwab, B de Andres, B Manoury, BL Makepeace, BW Li, C Klotz, C Martin, C Martin, D Abraham, D Abraham, D Horst, D Knox, David W. Taylor, DH Barouch, DL Redmond, E Maraskovsky, G Ahlen, G Nchinda, GT Joseph, HA Farid, HongLin Luo, J Gardon, J Murray, JE Allen, JE Allen, JJ Donnelly, JP Hewitson, Judith E. Allen, KJ Fairlie-Clarke, KJ Ishii, LM Mir, LM Mir, LvG Jørgensen, MD Taylor, MD Taylor, MY Osei-Atweneboana, N Gomez-Escobar, Nick Gray, O Golden, PJ Hotez, R Ihaka, RM Maizels, RT Rwegoshora, S Babayan, S Frontier, S Mendez, S Ramachandran, S Thirugnanam, SA Babayan, SA Babayan, SB Anand, SB Anand, SB Anand, Simon A. Babayan, SM Sumida, Stephen John Davies, W Harnett, WF Gregory, WF Gregory, Y Dash, Y Wu   +63 more
core   +4 more sources

The Cysteine Protease–Cysteine Protease Inhibitor System Explored in Soybean Nodule Development

Agronomy, 2013
Almost all protease families have been associated with plant development, particularly senescence, which is the final developmental stage of every organ before cell death.
Marian Dorcas Quain, Karl Kunert, Christine Helen Foyer, Ignatious Ncube, Matome Eugene Makgopa, Stefan van Wyk, Magdeleen du Plessis, Urte Schlüter, Barend Juan Vorster   +8 more
doaj   +1 more source

Are ticks venomous animals? [PDF]

, 2017
[Introduction]: As an ecological adaptation venoms have evolved independently in several species of Metazoa. As haematophagous arthropods ticks are mainly considered as ectoparasites due to directly feeding on the skin of animal hosts. Ticks are of major
Cabezas-Cruz, Alejandro, Valdés, James J.   +1 more
core   +1 more source

Cysteine proteinases and cystatins

Brazilian Archives of Biology and Technology, 2003
This review describeds the definition, localization, functions and examples of cysteine proteinases and their protein inhibitors in vertebrate, non-vertebrate animals and plants. These inhibitors are related with defense mechanisms of plant against pests.
Adeliana S. Oliveira, José Xavier-Filho, Maurício P. Sales   +2 more
doaj   +1 more source

The Influence of (Poly)phenol Intake in Saliva Proteome: Short- and Medium-Term Effects of Apple

Foods, 2023
The relationship between salivary proteome and dietary habits was studied in previous works, where a relationship between salivary proteins like cystatins and polyphenol/tannin levels in diet was observed.
Teresa Louro, Laura Carreira, Inês Caeiro, Carla Simões, Sara Ricardo-Rodrigues, Ana Elisa Rato, Fernando Capela e Silva, Henrique Luís, Pedro Moreira, Elsa Lamy   +9 more
doaj   +1 more source

Structural and functional analysis of the pro-domain of human cathelicidin, LL-37 [PDF]

, 2013
Cathelicidins form a family of small host defense peptides distinct from another class of cationic antimicrobial peptides, the defensins. They are expressed as large precursor molecules with a highly conserved pro-domain known as the cathelin-like domain
Beckley, Amy J., Ericksen, Bryan, Lan, Liqiong, Li, Xiangdong, Ling, Minhua, Lu, Wuyuan, Pazgier, Marzena, Pozharski, Edwin, Shi, Jishu N., Toth, Eric, Yuan, Weirong, Zhan, Changyou, Zou, Guozhang   +12 more
core   +1 more source

P43

EJC Supplements, 2015
Cystatins are natural endogenous inhibitors of cysteine proteases universally involved into development of different tumors. Tumor growth and metastazing include increased consumption of these inhibitors, followed by decreased level of cystatins and ...
M. Dikovskaya, T. Korolenko, A. Trunov
doaj   +1 more source

Plant protein-coding gene families: emerging bioinformatics approaches [PDF]

, 2011
Protein-coding gene families are sets of similar genes with a shared evolutionary origin and, generally, with similar biological functions. In plants, the size and role of gene families has been only partially addressed.
Altschul, Andreeva, Attwood, Beers, Benson, Bru, Cambra, Carretero-Paulet, Chain, Chen, Cochrane, Cuff, de Lima Morais, Del Bem, Enright, Faro, Feng, Finn, Fraser, Frech, Garcia-Lorenzo, Guilfoyle, Guindon, Haft, Hunter, Kaminuma, Kersey, Klimke, Kolodziejczyk, Kotsyfakis, Lees, Leinonen, Letunic, Li, Li, Lijavetzky, Lima, Liolios, Lu, Manuel Martinez, Marchler-Bauer, Martinez, Martinez, Martinez, Mi, Moreno-Risueno, Mugford, Nikolskaya, Nissen, Paterson, Pearson, Perez-Rodriguez, Philippe, Plett, Proost, Pruitt, Rautengarten, Rawlings, Remington, Roberts, Rouard, Sigrist, Singh, Swaminathan, Takahashi, Tatusov, Tian, Tyler, UniProt_Consortium, Van de Peer, Vercammen, Wang, Yu   +72 more
core   +2 more sources