Results 11 to 20 of about 3,506 (234)
Maqui berry cystatin inhibits cathepsin k activity and stimulates osteogenic differentiation of human dental pulp cells [PDF]
Journal of Applied Oral ScienceObjectives Cystatins, endogenous inhibitors of cysteine proteases, regulate extracellular matrix degradation. Their plant-derived homologs (phytocystatins) include MaquiCPI-3, a recombinant protein obtained from Aristotelia chilensis (maqui berry). This
Luana Raphael da Silva +5 more
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Cystatins: unravelling the biological implications for neuroprotection [PDF]
Archives of Medical Science, 2023 Cystatins, a family of proteins known for their inhibitory role against cysteine proteases, have garnered significant attention in the field of neurodegeneration. Numerous genetic, experimental, and clinical studies concerning cystatin C suggest it plays
Bartłomiej Stańczykiewicz +3 more
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Host-Directed Therapies Based on Protease Inhibitors to Control Mycobacterium tuberculosis and HIV Coinfection [PDF]
MicroorganismsDespite continuous and extensive global efforts in the fight against tuberculosis (TB), this infectious disease continues to exert a tremendous burden on public health concerns and deaths worldwide.
Manoj Mandal +3 more
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The Acari Hypothesis, V: deciphering allergenicity [PDF]
Frontiers in AllergyThe Acari Hypothesis posits that acarians, i.e., mites and ticks, are operative agents of allergy. It derived from observations that allergens are molecular elements of acarians or acarian foodstuffs.
Andrew C. Retzinger +1 more
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Differential Effect of Novel Plant Cystatins on the Adhesive Behaviour of Normal and Cancer Breast Cells [PDF]
International Journal BioautomationIn the present work, we have investigated a novel recombinant cystatin dgECP1 and its mutant form, dgECP1m1, focused on their impact on the adhesive behaviour of two breast cell lines: the cancerous, MDA-MB-231, and the normal, MCF-10A.
Kamelia Hristova-Panusheva +2 more
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Journal of Health Care for the Poor and Underserved, 2010 Cystatins, the classical inhibitors of C1 cysteine proteinases, have been extensively studied and reviewed in the literature. Over the last 20 years, however, proteins containing cystatin domains but lacking protease inhibitory activities have been identified, and most likely more will be described in the near future.
Josiah, Ochieng, Gautam, Chaudhuri
openaire +2 more sources
Frontiers in Immunology, 2021 The moment a very old bacterial pathogen met a young virus from the 80’s defined the beginning of a tragic syndemic for humanity. Such is the case for the causative agent of tuberculosis and the human immunodeficiency virus (HIV).
Elsa Anes +2 more
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Frontiers in Immunology, 2021 Tuberculosis owes its resurgence as a major global health threat mostly to the emergence of drug resistance and coinfection with HIV. The synergy between HIV and Mycobacterium tuberculosis (Mtb) modifies the host immune environment to enhance both viral ...
David Pires +9 more
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Comparative analysis of cystatin superfamily in platyhelminths. [PDF]
PLoS ONE, 2015 The cystatin superfamily is comprised of cysteine proteinase inhibitors and encompasses at least 3 subfamilies: stefins, cystatins and kininogens. In this study, the platyhelminth cystatin superfamily was identified and grouped into stefin and cystatin ...
Aijiang Guo
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Frontiers in Neuroscience, 2021 Alzheimer disease (AD) is the most prevalent neurodegenerative disease in the elderly, characterized by accumulation in the brain of misfolded proteins, inflammation, and oxidative damage leading to neuronal cell death.
Cristina Contini +14 more
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