Cystatins in Immune System [PDF]
Journal of Cancer, 2013 Cystatins comprise a large superfamily of related proteins with diverse biological activities. They were initially characterised as inhibitors of lysosomal cysteine proteases, however, in recent years some alternative functions for cystatins have been ...
Špela Magister, Janko Kos
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Physical exercise stimulates salivary secretion of cystatins.
PLoS ONE, 2019 Physical exercise is known to activate the sympathetic nervous system, which influences the production of saliva from salivary glands. Our examination of saliva collected from highly trained athletes before and after a number of physical competititions ...
Marcelo de Lima Sant'Anna +6 more
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Proteolytic Activity Inhibition in Gingival Fluid by Cysteine Protease Inhibitors Obtained from Egg White and Fallopia japonica Extract: An In Vitro Study [PDF]
BiomedicinesBackground/Objectives: Gingipains produced by P. gingivalis have been shown to be directly related to periodontal tissue degradation and are significant molecular targets in therapy of periodontitis.
Maciej Siewiński +12 more
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Parasites & Vectors, 2015 Background Cystatins are a group of cysteine protease inhibitors responsible for physiological proteolysis regulation and present in a wide range of organisms. Studies about this class of inhibitors in parasites have contributed to clarify their roles in
Luís Fernando Parizi +8 more
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Environment-Dependent Dimerization as a Functional Switch in Leech Cystatin CysHv [PDF]
ToxinsCystatins from hematophagous organisms modulate host proteases and are promising biotechnological tools. CysHv, a secreted cystatin from the Brazilian leech Haementeria vizottoi, was previously characterized as a potent inhibitor of papain and cathepsin ...
Melissa Regina Fessel +2 more
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Type 2 Cystatins and Their Roles in the Regulation of Human Immune Response and Cancer Progression [PDF]
Cancers (Basel), 2023 Cystatins are a family of intracellular and extracellular protease inhibitors that inhibit cysteine cathepsins—a group of lysosomal cysteine proteases that participate in multiple biological processes, including protein degradation and post ...
Zijun Zhang, Fenghuang Zhan
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Maqui berry cystatin inhibits cathepsin k activity and stimulates osteogenic differentiation of human dental pulp cells [PDF]
Journal of Applied Oral ScienceObjectives Cystatins, endogenous inhibitors of cysteine proteases, regulate extracellular matrix degradation. Their plant-derived homologs (phytocystatins) include MaquiCPI-3, a recombinant protein obtained from Aristotelia chilensis (maqui berry). This
Luana Raphael da Silva +5 more
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Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host.
Jindřich Chmelař +5 more
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Differential Effect of Novel Plant Cystatins on the Adhesive Behaviour of Normal and Cancer Breast Cells [PDF]
International Journal BioautomationIn the present work, we have investigated a novel recombinant cystatin dgECP1 and its mutant form, dgECP1m1, focused on their impact on the adhesive behaviour of two breast cell lines: the cancerous, MDA-MB-231, and the normal, MCF-10A.
Kamelia Hristova-Panusheva +2 more
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The Acari Hypothesis, V: deciphering allergenicity [PDF]
Frontiers in AllergyThe Acari Hypothesis posits that acarians, i.e., mites and ticks, are operative agents of allergy. It derived from observations that allergens are molecular elements of acarians or acarian foodstuffs.
Andrew C. Retzinger +1 more
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