Structural Dynamics Investigation of Human Family 1 & 2 Cystatin-Cathepsin L1 Interaction: A Comparison of Binding Modes. [PDF]
PLoS ONE, 2016 Cystatin superfamily is a large group of evolutionarily related proteins involved in numerous physiological activities through their inhibitory activity towards cysteine proteases. Despite sharing the same cystatin fold, and inhibiting cysteine proteases
Suman Kumar Nandy, Alpana Seal
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Evolution of C, D and S-type cystatins in mammals: an extensive gene duplication in primates.
PLoS ONE, 2014 Cystatins are a family of inhibitors of cysteine peptidases that comprises the salivary cystatins (D and S-type cystatins) and cystatin C. These cystatins are encoded by a multigene family (CST3, CST5, CST4, CST1 and CST2) organized in tandem in the ...
Patrícia de Sousa-Pereira +5 more
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Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain [PDF]
, 2001 Within the cystatin superfamily, only kininogen domain 2 (KD2) is able to inhibit μ- and m-calpain. In an attempt to elucidate the structural requirements of cystatins for calpain inhibition, we constructed recombinant hybrids of human stefin B (an ...
Anastasi A. +14 more
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Evolutionary Analysis of the Cystatin Family in Three Schistosoma Species
Frontiers in Genetics, 2014 The cystatin family comprises cysteine protease inhibitors distributed in 3 subfamilies (I25A-C). Family members lacking cystatin activity are currently unclassified. Little is known about the evolution of Schistosoma cystatins, their physiological roles,
Yesid eCuesta-Astroz +4 more
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Frontiers in Immunology, 2021 Cysteine cathepsins are primarily involved in the degradation and recycling of proteins in endo-lysosomal compartments but are also gaining recognition as pivotal proteolytic contributors to various immune functions.
Milica Perišić Nanut +4 more
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Cystatin C and lactoferrin concentrations in biological fluids as possible prognostic factors in eye tumor development [PDF]
, 2013 Objectives. To investigate the possible role of cystatin C in eye biological fluids locally and in serum and lactoferrin revealing anti-tumor activity in eye tumor development. Background.
Ananthi S +19 more
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Cystatin C and cystatin SN as possible soluble tumor markers in malignant uveal melanoma
Radiology and Oncology, 2021 The aim of the study was to determine the concentration of endogenous cystatin C and cystatin SN, as potential tumor biomarkers, in the serum and biological fluids of the eye in both healthy controls and patients with uveal melanoma.
Dikovskaya Maria A. +8 more
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A barley cysteine-protease inhibitor reduces teh performance of two aphid species in artificial diets and transgenic arabidopsis plants [PDF]
, 2011 Cystatins from plants have been implicated in plant defense towards insects, based on their role as inhibitors of heterologous cysteine-proteinases. We have previously characterized thirteen genes encoding cystatins (HvCPI-1 to HvCPI-13) from barley ...
A Azzouz +49 more
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How Different Snacks Produce a Distinct Effect in Salivary Protein Composition
Molecules, 2021 Saliva secretion changes in response to different stimulation. Studies performed in animals and humans suggest that dietary constituents may influence saliva composition, although the dynamics of these changes, and how they are specific for each type of ...
Carla Simões +4 more
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Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesis [PDF]
, 2009 Helminth immunology is a field which has changed beyond recognition in the past 30 years, transformed not only by new technologies from cDNA cloning to flow cytometry, but also conceptually as our definition of host immune pathways has matured.
Maizels, R M
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