Results 31 to 40 of about 10,373 (179)
Human cysteine cathepsins are not reliable markers of infection by Pseudomonas aeruginosa in cystic fibrosis. [PDF]
PLoS ONE, 2011 Cysteine cathepsins have emerged as new players in inflammatory lung disorders. Their activities are dramatically increased in the sputum of cystic fibrosis (CF) patients, suggesting that they are involved in the pathophysiology of CF.
Clément Naudin +9 more
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Marine Drugs, 2022 Cathepsins are lysosomal cysteine proteases belonging to the papain family and play crucial roles in intracellular protein degradation/turnover, hormone maturation, antigen processing, and immune responses.
Yuqing Li +7 more
doaj +1 more source
Cysteine Cathepsin Activity Regulation by Glycosaminoglycans [PDF]
BioMed Research International, 2014 Cysteine cathepsins are a group of enzymes normally found in the endolysosomes where they are primarily involved in intracellular protein turnover but also have a critical role in MHC II-mediated antigen processing and presentation. However, in a number of pathologies cysteine cathepsins were found to be heavily upregulated and secreted into ...
Marko Novinec +2 more
openaire +2 more sources
The role of lysosomal cysteine proteases in tumor progression
Бюллетень сибирской медицины, 2009 Cysteine cathepsins have been known for a long time to play an important role in cancer progression. Here we summarize their impact to the hallmark processes of malignant growth such as cell proliferation, apoptosis, angiogenesis, invasion and metastasis.
M. S. Korovin +2 more
doaj +1 more source
Frontiers in Immunology, 2018 Natural killer T (NKT) cells exhibit a specific tissue distribution, displaying the liver the highest NKT/conventional T cell ratio. Upon antigen stimulation, NKT cells secrete Th1 cytokines, including interferon γ (IFNγ), and Th2 cytokines, including IL-
Álvaro de Mingo Pulido +6 more
doaj +1 more source
Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe. [PDF]
PLoS ONE, 2011 The papain family of cysteine cathepsins are actively involved in multiple stages of tumorigenesis. Because elevated cathepsin activity can be found in many types of human cancers, they are promising biomarkers that can be used to target radiological ...
Gang Ren +11 more
doaj +1 more source
Cysteine Cathepsins and the Cutting Edge of Cancer Invasion [PDF]
Cell Cycle, 2007 Cysteine cathepsins are a family of lysosomal proteases that are often upregulated in various human cancers, and have been implicated in distinct tumorigenic processes such as angiogenesis, proliferation, apoptosis and invasion. During cancer progression, cathepsins are often translocated to the cell surface of tumor cells or are secreted into the ...
Vasilena, Gocheva, Johanna A, Joyce
openaire +2 more sources
PLoS Pathogens, 2020 Over the last 2 decades, several coronaviruses (CoVs) have crossed the species barrier into humans, causing highly prevalent and severe respiratory diseases, often with fatal outcomes.
Anja Pišlar +7 more
doaj +1 more source
The Carboxypeptidase Activity of Cathepsin X is Not Controlled by Endogenous Inhibitors
Acta Chimica Slovenica, 2019 Cysteine cathepsins are peptidases with housekeeping functions that play different specific roles in different tissues. Endogenous peptidase inhibitors, such as cystatins and thyropins are the ultimate way of controlling their activity.
Urša Pečar Fonović +4 more
doaj +1 more source
Cysteine cathepsins: structure, physiological functions and their role in carcinogenesis [PDF]
Biomeditsinskaya Khimiya, 2021 Cysteine cathepsins (Cts) also known as thiol proteinases belong to the superfamily of cysteine proteinases (EC 3.4.22). Cts are known as lysosomal proteases responsible for the intracellular proteins degradation. All Cts are synthesized as zymogens, activation of which occurs autocatalytically.
T A, Gureeva +3 more
openaire +2 more sources