Results 51 to 60 of about 10,373 (179)

Differential impact of cysteine cathepsins on genetic mouse models of de novo carcinogenesis: cathepsin B as emerging therapeutic target

Frontiers in Pharmacology, 2012
Lysosomal cysteine cathepsins belong to a family of 11 human proteolytic enzymes. Some of them correlate with progression in a variety of cancers and therefore are considered as potential therapeutic targets.
Thomas eReinheckel, Christoph ePeters, Achim eKrüger, Boris eTurk, Olga eVasiljeva   +4 more
doaj   +1 more source

Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins

Neoplasia: An International Journal for Oncology Research, 2013
One of the noncellular microenvironmental factors that contribute to malignancy of solid tumors is acidic peritumoral pH. We have previously demonstrated that extracellular acidosis leads to localization of the cysteine pro-tease cathepsin B on the tumor
Jennifer M Rothberg, Kate M Bailey, Jonathan W Wojtkowiak, Yael Ben-Nun, Matthew Bogyo, Ekkehard Weber, Kamiar Moin, Galia Blum, Raymond R Mattingly, Robert J Gillies, Bonnie F Sloane   +10 more
doaj   +1 more source

Mendelian randomization analyses explore the relationship between cathepsins and lung cancer

Communications Biology, 2023
Lung cancer, a major contributor to cancer-related fatalities worldwide, involves a complex pathogenesis. Cathepsins, lysosomal cysteine proteases, play roles in various physiological and pathological processes, including tumorigenesis.
Jialin Li, Mingbo Tang, Xinliang Gao, Suyan Tian, Wei Liu   +4 more
doaj   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets

Cells
Cysteine cathepsins F and W are members of the papain-like cysteine protease family, which have distinct structural features and functional roles in various physiological and pathological processes.
Kristina Zdravkova, Olja Mijanovic, Ana Brankovic, Polina M. Ilicheva, Aleksandra Jakovleva, Jelena Karanovic, Milena Pualic, Dusan Pualic, Aleksandr A. Rubel, Lyudmila V. Savvateeva, Alessandro Parodi, Andrey A. Zamyatnin   +11 more
doaj   +1 more source

A Cysteine Protease Gene Is Expressed Early in Resistant Potato Interactions with Phytophthora infestans

Molecular Plant-Microbe Interactions, 1999
A potato cysteine protease (cyp) cDNA expressed at an early stage of an incompatible interaction with Phytophthora infestans was isolated. Both the nucleotide and deduced amino acid sequences are highly homologous to those of a tomato cysteine protease ...
Anna O. Avrova, Helen E. Stewart, Walter De Jong, Jacqueline Heilbronn, Gary D. Lyon, Paul R. J. Birch   +5 more
doaj   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Comprehensive search for cysteine cathepsins in the human genome [PDF]

Biological Chemistry, 2004
Our study was aimed at examinating whether or not the human genome encodes for previously unreported cysteine cathepsins. To this end, we used analyses of the genome sequence and mRNA expression levels. The program TBLASTN was employed to scan the draft sequence of the human genome for the 11 known cysteine cathepsins.
Andrea, Rossi, Quinn, Deveraux, Boris, Turk, Andrej, Sali   +3 more
openaire   +2 more sources

TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development

Cell Reports, 2018
Summary: Cysteine cathepsins play roles during development and disease beyond their function in lysosomal protein turnover. Here, we leverage a fluorescent activity-based probe (ABP), BMV109, to track cysteine cathepsins in normal and diseased zebrafish ...
Heather Flanagan-Steet, Courtney Christian, Po-Nien Lu, Megan Aarnio-Peterson, Laura Sanman, Stephanie Archer-Hartmann, Parastoo Azadi, Matthew Bogyo, Richard A. Steet   +8 more
doaj   +1 more source