Structural basis for specificity of propeptide-enzyme interaction in barley C1A cysteine peptidases. [PDF]
PLoS ONE, 2012 C1A cysteine peptidases are synthesized as inactive proenzymes. Activation takes place by proteolysis cleaving off the inhibitory propeptide. The inhibitory capacity of propeptides from barley cathepsin L and B-like peptidases towards commercial and ...
Inés Cambra +3 more
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Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na(+)/H(+) exchange inhibitor Cariporide (R) in isolated perfused rabbit hearts [PDF]
, 2008 The calpain inhibitor A-705253 and the Na(+)/H(+) exchange inhibitor Cariporide (R) were studied in isolated perfused rabbit hearts subjected to 60 min occlusion of the ramus interventricularis of the left coronary artery (below the origin of the first ...
Bardenheuer H. +19 more
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Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells [PDF]
, 2014 Formation of the atherosclerotic intima must involve altered metabolism of the elastin-rich arterial extracellular matrix. Proteases potentially involved in these processes remain unclear.
Chapman, H A +4 more
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The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease
Frontiers in Cell and Developmental Biology, 2017 Kidney disease is worldwide the 12th leading cause of death affecting 8–16% of the entire population. Kidney disease encompasses acute (short-lasting episode) and chronic (developing over years) pathologies both leading to renal failure.
Pasquale Cocchiaro +14 more
doaj +1 more source
Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety. [PDF]
PLoS ONE, 2011 BACKGROUND: Redox cycling compounds have been reported to cause false positive inhibition of proteases in drug discovery studies. This kind of false positives can lead to unusually high hit rates in high-throughput screening campaigns and require further
Bojana Mirković +3 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
PLoS ONE, 2015 Cathepsins are proteases involved in the ability of parasites to overcome and/or modulate host defenses so as to complete their own lifecycle. However, the mechanisms underlying this ability of cathepsins are still poorly understood.
Waleska Maldonado-Aguayo +3 more
doaj +1 more source
Frontiers in Pharmacology, 2012 Lysosomal cysteine cathepsins belong to a family of 11 human proteolytic enzymes. Some of them correlate with progression in a variety of cancers and therefore are considered as potential therapeutic targets.
Thomas eReinheckel +4 more
doaj +1 more source
Mendelian randomization analyses explore the relationship between cathepsins and lung cancer
Communications Biology, 2023 Lung cancer, a major contributor to cancer-related fatalities worldwide, involves a complex pathogenesis. Cathepsins, lysosomal cysteine proteases, play roles in various physiological and pathological processes, including tumorigenesis.
Jialin Li +4 more
doaj +1 more source
Multiplex Zymography Captures Stage-specific Activity Profiles of Cathepsins K, L, and S in Human Breast, Lung, and Cervical Cancer [PDF]
, 2011 Background Cathepsins K, L, and S are cysteine proteases upregulated in cancer and proteolyze extracellular matrix to facilitate metastasis, but difficulty distinguishing specific cathepsin activity in complex tissue extracts confounds scientific studies
Binbin Chen, Manu O Platt
core +4 more sources